Publications by authors named "David Ledieu"

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A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab.
Jeffrey D Kearns, Paul Wassmann, Ufuk Olgac, Marie Fichter, Brigitte Christen, David Ledieu

Sci Transl Med· February 2023

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Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology.
Kea Martin, Ursula Junker, Elaine Tritto, Esther Sutter, Tina Rubic-Schneider, David Ledieu

Front Immunol· March 2021

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Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human.
Francois Pognan, J Andreas Mahl, Maria Papoutsi, David Ledieu, Marc Raccuglia

Arch Toxicol· May 2018

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A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety.
Myriam Defontis, Serge Côté, David Ledieu

Exp Toxicol Pathol· June 2017

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Editor's Highlight: Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats.
Marianne Uteng, Andreas Mahl, Nicolau Beckmann, Alessandro Piaia, David Ledieu

Toxicol Sci· January 2017

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Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies.
Amanda Benjamin, David J Gallacher, Andrea Greiter-Wilke, Jean-Michel Guillon, Cheiko Kasai, David Ledieu

J Pharmacol Toxicol Methods· July 2016

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Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation.
Jens Schümann, Armelle Grevot, David Ledieu, Armin Wolf, Anna Schubart

Toxicol Pathol· July 2015

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Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo.
Nicole Urtz, Florian Gaertner, Marie-Luise von Bruehl, Sue Chandraratne, Faridun Rahimi, David Ledieu

Circ Res· July 2015

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Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis.
Natali B Bauer, Thaqif El Khassawna, Fee Goldmann, Martina Stirn, David Ledieu

Exp Toxicol Pathol· April 2015

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Optimization of Multiplate(®) whole blood platelet aggregometry in the Beagle dog and Wistar rat for ex vivo drug toxicity testing.
Myriam Defontis, Serge Côté, Martina Stirn, David Ledieu

Exp Toxicol Pathol· July 2013

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Preclinical evaluation of potential nilotinib cardiotoxicity.
Armin Wolf, Philippe Couttet, Min Dong, Olivier Grenet, Marcia Heron, David Ledieu

Leuk Res· May 2011

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International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.
Brad Bolon, Erio Barale-Thomas, Alys Bradley, Robert A Ettlin, Carla A S Franchi, David Ledieu

Exp Toxicol Pathol· January 2011

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Sublingual and submandibular blood collection in mice: a comparison of effects on body weight, food consumption and tissue damage.
Maike Heimann, Daniel Robert Roth, David Ledieu, Rudolf Pfister, Werner Classen

Lab Anim· October 2010

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International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.
Brad Bolon Chair, Erio Barale-Thomas, Alys Bradley, Robert A Ettlin, Carla A S Franchi, David Ledieu

Toxicol Pathol· October 2010

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Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies.
Armin Wolf, Philippe Couttet, Min Dong, Olivier Grenet, Marcia Heron, David Ledieu

Leuk Res· September 2010

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International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.
Brad Bolon, Erio Barale-Thomas, Alys Bradley, Robert A Ettlin, Carla A S Franchi, David Ledieu

J Toxicol Pathol· September 2010

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Effects of hepatic drug-metabolizing enzyme induction on clinical pathology parameters in animals and man.
Daniela Ennulat, Dana Walker, Frances Clemo, Michal Magid-Slav, David Ledieu

Toxicol Pathol· August 2010

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Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805.
Fabienne Baffert, Catherine H Régnier, Alain De Pover, Carole Pissot-Soldermann, Gisele A Tavares, David Ledieu

Mol Cancer Ther· July 2010

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Detection of reticulated platelets in whole blood of rats using flow cytometry.
Alexander Pankraz, David Ledieu, Dominique Pralet, Anne Provencher-Bolliger

Exp Toxicol Pathol· September 2008

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Altered gene expression in rat mesenteric tissue following in vivo exposure to a phosphodiesterase 4 inhibitor.
Nicolas Daguès, Valérie Pawlowski, Ghislaine Guigon, David Ledieu, Cécile Sobry

Toxicol Appl Pharmacol· January 2007

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Acute megakaryoblastic leukemia with erythrophagocytosis and thrombosis in a dog.
David Ledieu, Xavier Palazzi, Thierry Marchal, Corinne Fournel-Fleury

Vet Clin Pathol· June 2005

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Prognostic significance of morphological subtypes in canine malignant lymphomas during chemotherapy.
Frédérique Ponce, Jean-Pierre Magnol, David Ledieu, Thierry Marchal, Vanessa Turinelli

Vet J· March 2004

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