Publications by authors named "David Leitsch"

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Downregulation of an NfsA-like nitroreductase causes metronidazole resistance in Gardnerella vaginalis.
Ana Paunkov, Anna-Lena Mayr, Vera Oberbauer, Timo Schwebs, Lorenzo Corsini, David Leitsch

Int J Antimicrob Agents· December 2025

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Culturing of Giardia lamblia under microaerobic conditions can impact metronidazole susceptibility by inducing increased expression of antioxidant enzymes.
Kateryna Starynets, Ana Paunkov, Anja Wagner, Klaus Kratochwill, Christian Klotz, David Leitsch

Int J Parasitol Drugs Drug Resist· April 2025

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Roles of efflux pumps and nitroreductases in metronidazole-resistant Trichomonas vaginalis.
Ana Paunkov, Doris Strasser, Philipp Huber, David Leitsch

Parasitol Res· February 2025

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Evaluating the amoeba thioredoxin reductase selenoprotein as potential drug target for treatment of Acanthamoeba infections.
Alvie Loufouma-Mbouaka, Attila Andor, David Leitsch, Jorge Pérez-Serrano, Elias S J Arnér

Int J Parasitol Drugs Drug Resist· December 2024

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Comparative proteomic analysis of metronidazole-sensitive and resistant Trichomonas vaginalis suggests a novel mode of metronidazole action and resistance.
Anna-Lena Mayr, Ana Paunkov, Karin Hummel, Ebrahim Razzazi-Fazeli, David Leitsch

Int J Parasitol Drugs Drug Resist· December 2024

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A Comparison of Bottom-Up Proteomic Sample Preparation Methods for the Human Parasite .
Anna-Lena Mayr, Karin Hummel, David Leitsch, Ebrahim Razzazi-Fazeli

ACS Omega· February 2024

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Proteomics-Based RT-qPCR and Functional Analysis of 18 Genes in Metronidazole Resistance of .
Bakhtiyar Mahmood, Ana Paunkov, Malgorzata Kupc, Katalin Burián, Elisabeth Nagy, David Leitsch

Antibiotics (Basel)· February 2024

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The effects of identical nim gene-insertion sequence combinations on the expression of the nim genes and metronidazole resistance in Bacteroides fragilis strains.
Bakhtiyar Mahmood, Hajnalka Juhász, David Leitsch, József Sóki

Anaerobe· June 2023

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Proteomic analysis of metronidazole resistance in the human facultative pathogen .
Ana Paunkov, Karin Hummel, Doris Strasser, József Sóki, David Leitsch

Front Microbiol· March 2023

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Initial expression levels of nimA are decisive for protection against metronidazole in Bacteroides fragilis.
Małgorzata Kupc, Ana Paunkov, Doris Strasser, József Sóki, David Leitsch

Anaerobe· October 2022

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Modulation of Iron Import and Metronidazole Resistance in Harboring a Gene.
Ana Paunkov, József Sóki, David Leitsch

Front Microbiol· June 2022

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Transcriptional changes of proteins of the thioredoxin and glutathione systems in Acanthamoeba spp. under oxidative stress - an RNA approach.
Martina Köhsler, David Leitsch, Alvie Loufouma Mbouaka, Maximilian Wekerle, Julia Walochnik

Parasite· May 2022

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Haemin deprivation renders Bacteroides fragilis hypersusceptible to metronidazole and cancels high-level metronidazole resistance.
Ana Paunkov, Katrin Gutenbrunner, József Sóki, David Leitsch

J Antimicrob Chemother· March 2022

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Characterization of the components of the thioredoxin system in Bacteroides fragilis and evaluation of its activity during oxidative stress.
Ana Paunkov, Małgorzata Kupc, József Sóki, David Leitsch

Anaerobe· February 2022

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Antimicrobial effect of auranofin against Acanthamoeba spp.
Alvie Loufouma Mbouaka, David Leitsch, Martina Koehsler, Julia Walochnik

Int J Antimicrob Agents· November 2021

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A reassessment of the role of oxygen scavenging enzymes in the emergence of metronidazole resistance in trichomonads.
Virág Gehl, Ana Paunkov, David Leitsch

Int J Parasitol Drugs Drug Resist· August 2021

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Molecular characterization of metronidazole resistant Bacteroides strains from Kuwait.
Zain Baaity, Wafaa Jamal, Vincent O Rotimi, Katalin Burián, David Leitsch

Anaerobe· June 2021

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An unusual thioredoxin system in the facultative parasite Acanthamoeba castellanii.
David Leitsch, Alvie Loufouma Mbouaka, Martina Köhsler, Norbert Müller, Julia Walochnik

Cell Mol Life Sci· April 2021

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Recent advances in the molecular biology of the protist parasite .
David Leitsch

Fac Rev· March 2021

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A powerful qPCR-high resolution melting assay with taqman probe in plasmodium species differentiation.
Aline Lamien-Meda, Hans-Peter Fuehrer, David Leitsch, Harald Noedl

Malar J· February 2021

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Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis.
Raúl Argüello-García, David Leitsch, Tina Skinner-Adams, M Guadalupe Ortega-Pierres

Adv Parasitol· July 2020

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Validation of reference genes for the normalization of RT-qPCR gene expression in Acanthamoeba spp.
Martina Köhsler, David Leitsch, Norbert Müller, Julia Walochnik

Sci Rep· June 2020

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A novel 5-Plex qPCR-HRM assay detecting human diarrheal parasites.
Aline Lamien-Meda, Renate Schneider, Julia Walochnik, Herbert Auer, Ursula Wiedermann, David Leitsch

Gut Pathog· May 2020

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Identification of the NADH-oxidase gene in Trichomonas vaginalis.
Aline Lamien-Meda, David Leitsch

Parasitol Res· February 2020

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Metabolomic Profiling of Wildtype and Transgenic Strains by H HR-MAS NMR Spectroscopy.
Joachim Müller, Martina Vermathen, David Leitsch, Peter Vermathen, Norbert Müller

Metabolites· January 2020

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