Publications by authors named "David Linehan"

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Opioid Stewardship: Successful, Scalable, and Adaptable Departmental Opioid Reduction Program.
Alexa D Melucci, Olivia Lynch, Michele Lawrence, John Bramley, Elizabeth Levatino, David Linehan

J Am Coll Surg· January 2026

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Assessment of the National Institutes of Health Salary Cap Gap Reveals the Increasing Financial Burden of Training and Hiring Surgeon-Scientists.
Juliet Emamaullee, Sarah Bangerth, Krista L Haines, Shannon Jordan, David Linehan

Ann Surg· September 2025

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Improving Stereotactic Body Radiation Therapy by Rewiring Immunosuppressive Neutrophils in Murine Pancreatic Ductal Adenocarcinoma.
Joseph D Murphy, Gary Hannon, Bradley N Mills, Angela L Hughson, Taylor P Uccello, David C Linehan

Int J Radiat Oncol Biol Phys· July 2025

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A Reassessment of the Clinical Utility of Ga-DOTATATE PET/CT in Patients With Gastroenteropancreatic Neuroendocrine Tumors.
Orjola Prela, Brennen Caveney, Myla Strawderman, David Linehan, Eva Galka

J Surg Oncol· June 2025

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Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models.
Jian Ye, Shuyang S Qin, Angela L Hughson, Gary Hannon, Noah A Salama, David Linehan

J Immunother Cancer· May 2025

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Postdocs Focus on Research-Surgeons Provide Patient Care-Reply.
Jennifer E B Harman, David C Linehan, Anusha Naganathan

JAMA Surg· April 2025

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Blockade of LIF and PD-L1 Enhances Chemotherapy in Preclinical PDAC Models.
Jian Ye, Shuyang S Qin, Angela L Hughson, Gary Hannon, Tara G Vrooman, David C Linehan

Cancers (Basel)· January 2025

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Supporting Surgeon-Scientists to Prosper as Researchers.
Jennifer E B Harman, David C Linehan, Anusha Naganathan

JAMA Surg· December 2024

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Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer.
Angela L Hughson, Gary Hannon, Noah A Salama, Tara G Vrooman, Caroline A Stockwell, David C Linehan

Mol Ther Nucleic Acids· December 2024

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Pan-lysyl oxidase inhibition disrupts fibroinflammatory tumor stroma, rendering cholangiocarcinoma susceptible to chemotherapy.
Paul R Burchard, Luis I Ruffolo, Nicholas A Ullman, Benjamin S Dale, Yatee A Dave, David C Linehan

Hepatol Commun· August 2024

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Platelet-activating factor (PAF) promotes immunosuppressive neutrophil differentiation within tumors.
Ankit Dahal, Yeonsun Hong, Jocelyn S Mathew, Adam Geber, Sarah Eckl, David C Linehan

Proc Natl Acad Sci U S A· August 2024

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Smad4 restricts injury-provoked biliary proliferation and carcinogenesis.
William B Alexander, Wenjia Wang, Margaret A Hill, Michael R O'Dell, Luis I Ruffolo, David C Linehan

Dis Model Mech· June 2024

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Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes.
Xianlu Laura Peng, Elena V Kharitonova, Yi Xu, Joseph F Kearney, Changfei Luan, David C Linehan

bioRxiv· May 2024

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Middle-Preserving Pancreatectomy for Multicentric Solid Pseudopapillary Neoplasm in a 10-Year-Old Female.
Grace Marshall, Matthew Byrne, Korry Wirth, Xiaoyan Liao, David C Linehan

European J Pediatr Surg Rep· January 2024

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Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer.
Angela L Hughson, Gary Hannon, Noah A Salama, Tara G Vrooman, Caroline A Stockwell, David C Linehan

bioRxiv· November 2023

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New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy.
Taylor P Uccello, Maggie L Lesch, Sarah A Kintzel, Lauren B Gradzewicz, Lillia Lamrous, David C Linehan

Cell Death Dis· July 2023

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Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1.
Negar Khazan, Emily R Quarato, Niloy A Singh, Cameron W A Snyder, Taylor Moore, David C Linehan

Cancers (Basel)· June 2023

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CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models.
Jian Ye, Nicholas W Gavras, David C Keeley, Angela L Hughson, Gary Hannon, David C Linehan

J Immunother Cancer· May 2023

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New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy.
Scott Gerber, Taylor Uccello, Maggie Lesch, Sarah Kintzel, Lauren Gradzewicz, David Linehan

Res Sq· April 2023

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Radiation Therapy Exacerbates Tumor-Promoting Innervation and Nerve Signaling in Rectal Cancer.
Taylor P Uccello, Maggie L Lesch, Nicholas A Ullman, Sarah A Kintzel, Lauren B Gradzewicz, David C Linehan

Int J Radiat Oncol Biol Phys· March 2023

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Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity.
Hannah L Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S Winter, David C Linehan

Cancer Res· February 2023

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Predictors of opioid-free discharge after laparoscopic cholecystectomy.
Alexa D Melucci, Yatee A Dave, Olivia F Lynch, Shawn Hsu, Mariah R Erlick, David C Linehan

Am J Surg· January 2023

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Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer.
Andressa Dias Costa, Sara A Väyrynen, Akhil Chawla, Jinming Zhang, Juha P Väyrynen, David C Linehan

Clin Cancer Res· December 2022

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Immunologic Strategies in Pancreatic Cancer: Making Tumors .
Nicholas A Ullman, Paul R Burchard, Richard F Dunne, David C Linehan

J Clin Oncol· August 2022

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Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer.
Jian Ye, Bradley N Mills, Shuyang S Qin, Jesse Garrett-Larsen, Joseph D Murphy, David C Linehan

J Immunother Cancer· July 2022

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