Publications by authors named "David M Chipman"

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Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I.
Inna Belenky, Andrea Steinmetz, Maria Vyazmensky, Ze'ev Barak, Kai Tittmann, David M Chipman

FEBS J· June 2012

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Allosteric regulation in Acetohydroxyacid Synthases (AHASs)--different structures and kinetic behavior in isozymes in the same organisms.
Ze'ev Barak, David M Chipman

Arch Biochem Biophys· March 2012

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Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II.
Maria Vyazmensky, Andrea Steinmetz, Danilo Meyer, Ralph Golbik, Ze'ev Barak, David M Chipman

Biochemistry· April 2011

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Role of the C-terminal domain of the regulatory subunit of AHAS isozyme III: use of random mutagenesis with in vivo reconstitution (REM-ivrs).
Alexander Slutzker, Maria Vyazmensky, David M Chipman, Ze'ev Barak

Biochim Biophys Acta· March 2011

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Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli.
Andrea Steinmetz, Maria Vyazmensky, Danilo Meyer, Ze Ev Barak, Ralph Golbik, David M Chipman

Biochemistry· June 2010

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Interactions between large and small subunits of different acetohydroxyacid synthase isozymes of Escherichia coli.
Maria Vyazmensky, Yuri Zherdev, Alex Slutzker, Inna Belenky, Olga Kryukov, David M Chipman

Biochemistry· September 2009

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Reaction mechanisms of thiamin diphosphate enzymes: new insights into the role of a conserved glutamate residue.
Boaz Shaanan, David M Chipman

FEBS J· May 2009

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Allosteric regulation of Bacillus subtilis threonine deaminase, a biosynthetic threonine deaminase with a single regulatory domain.
Anat Shulman, Elena Zalyapin, Maria Vyazmensky, Ofer Yifrach, Ze'ev Barak, David M Chipman

Biochemistry· November 2008

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Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes.
Alexander Kaplun, Elad Binshtein, Maria Vyazmensky, Andrea Steinmetz, Ze'ev Barak, David M Chipman

Nat Chem Biol· February 2008

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Acetohydroxyacid synthase isozyme I from Escherichia coli has unique catalytic and regulatory properties.
Valerie Vinogradov, Maria Vyazmensky, Stanislav Engel, Inna Belenky, Alexander Kaplun, David M Chipman

Biochim Biophys Acta· March 2006

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Structure of the regulatory subunit of acetohydroxyacid synthase isozyme III from Escherichia coli.
Alexander Kaplun, Maria Vyazmensky, Yuri Zherdev, Inna Belenky, Alex Slutzker, David M Chipman

J Mol Biol· March 2006

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Mechanisms of acetohydroxyacid synthases.
David M Chipman, Ronald G Duggleby, Kai Tittmann

Curr Opin Chem Biol· October 2005

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Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy.
Michael Vinogradov, Alexander Kaplun, Maria Vyazmensky, Stanislav Engel, Ralph Golbik, David M Chipman

Anal Biochem· July 2005

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Column flow reactor using acetohydroxyacid synthase I from Escherichia coli as catalyst in continuous synthesis of R-phenylacetyl carbinol.
Stanislav Engel, Maria Vyazmensky, Dvora Berkovich, Ze'ev Barak, Jose Merchuk, David M Chipman

Biotechnol Bioeng· March 2005

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The carboligation reaction of acetohydroxyacid synthase II: steady-state intermediate distributions in wild type and mutants by NMR.
Kai Tittmann, Maria Vyazmensky, Gerhard Hübner, Ze'ev Barak, David M Chipman

Proc Natl Acad Sci U S A· January 2005

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Substrate range of acetohydroxy acid synthase I from Escherichia coli in the stereoselective synthesis of alpha-hydroxy ketones.
Stanislav Engel, Maria Vyazmensky, Dvora Berkovich, Ze'ev Barak, David M Chipman

Biotechnol Bioeng· December 2004

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Enhanced production of acetoin and butanediol in recombinant Enterobacter aerogenes carrying Vitreoscilla hemoglobin gene.
Hikmet Geckil, Ze'ev Barak, David M Chipman, Sebnem O Erenler, Dale A Webster

Bioprocess Biosyst Eng· October 2004

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Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme.
Kai Tittmann, Kathrin Schröder, Ralph Golbik, Jennifer McCourt, Alexander Kaplun, David M Chipman

Biochemistry· July 2004

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Role of a conserved arginine in the mechanism of acetohydroxyacid synthase: catalysis of condensation with a specific ketoacid substrate.
Stanislav Engel, Maria Vyazmensky, Michael Vinogradov, Dvora Berkovich, Ahuva Bar-Ilan, David M Chipman

J Biol Chem· June 2004

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Cloning and characterization of acetohydroxyacid synthase from Bacillus stearothermophilus.
Iris Porat, Michael Vinogradov, Maria Vyazmensky, Chung-Dar Lu, David M Chipman

J Bacteriol· January 2004

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Acetohydroxyacid synthase: a new enzyme for chiral synthesis of R-phenylacetylcarbinol.
Stanislav Engel, Maria Vyazmensky, Shimona Geresh, Ze'ev Barak, David M Chipman

Biotechnol Bioeng· September 2003

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NMR analysis of covalent intermediates in thiamin diphosphate enzymes.
Kai Tittmann, Ralph Golbik, Kathrin Uhlemann, Ludmila Khailova, Gunter Schneider, David M Chipman

Biochemistry· July 2003

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Acetohydroxyacid synthase from Mycobacterium avium and its inhibition by sulfonylureas and imidazolinones.
Yehudit Zohar, Monica Einav, David M Chipman, Ze'ev Barak

Biochim Biophys Acta· June 2003

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The N-terminal domain of the regulatory subunit is sufficient for complete activation of acetohydroxyacid synthase III from Escherichia coli.
Sharon Mendel, Michael Vinogradov, Maria Vyazmensky, David M Chipman, Ze'ev Barak

J Mol Biol· January 2003

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Isoleucine starvation caused by sulfometuron methyl in Salmonella typhimurium measured by translational frameshifting.
Alexander Kaplun, David M Chipman, Ze'ev Barak

Microbiology (Reading)· March 2002

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