Publications by authors named "David MacManus"

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The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy.
Gioia Riboni-Verri, Christopher E McMurran, Trisha Mukherjee, Cyrus Daruwalla, Jonathon Holland, David MacManus

Trials· December 2025

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A computational study of forward head posture biomechanics.
Katterine N Rios-Peralta, Afonso J C Silva, Ricardo J Alves-de-Sousa, Kathleen M Curran, David B MacManus

J Mech Behav Biomed Mater· November 2025

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A computational study on the effect of age and sex on arterial wall biomechanics.
Gustavo P Carmo, Adrianna Szumiejko, Fábio A O Fernandes, Ricardo J Alves de Sousa, David B MacManus

J Mech Behav Biomed Mater· September 2025

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Optical coherence tomography in secondary progressive multiple sclerosis: cross-sectional and longitudinal exploratory analysis from the MS-SMART randomised controlled trial.
Floriana De Angelis, James R Cameron, Arman Eshaghi, Richard Parker, Peter Connick, David MacManus

J Neurol Neurosurg Psychiatry· June 2025

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Computational Modelling of Protected and Unprotected Head Impacts in Rugby.
Thea Hodges, Adam Jones, Lucía Pérez Del Olmo, Ashwin Mishra, Brian Caulfield, David MacManus

Bioengineering (Basel)· March 2025

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Investigating the relationship between thalamic iron concentration and disease severity in secondary progressive multiple sclerosis using quantitative susceptibility mapping: Cross-sectional analysis from the MS-STAT2 randomised controlled trial.
Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, David MacManus

Neuroimage Rep· September 2024

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Long-term clinical outcomes in patients with CIS treated with interferon beta-1b: results from the 15-year follow up of the BENEFIT trial.
Ludwig Kappos, Gilles Edan, Mark S Freedman, Hans-Peter Hartung, Xavier Montalbán, David G MacManus

J Neurol· July 2024

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Longitudinal Metabolite Changes in Progressive Multiple Sclerosis: A Study of 3 Potential Neuroprotective Treatments.
Nevin A John, Bhavana S Solanky, Floriana De Angelis, Richard A Parker, Christopher J Weir, David MacManus

J Magn Reson Imaging· June 2024

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Vitamin D did not reduce multiple sclerosis disease activity after a clinically isolated syndrome.
Helmut Butzkueven, Anne-Louise Ponsonby, Mark S Stein, Robyn M Lucas, Deborah Mason, David MacManus

Brain· April 2024

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Treatment reduces the incidence of newly appearing multiple sclerosis lesions evolving into chronic active, slowly expanding lesions: A retrospective analysis.
Alberto Calvi, Zoe Mendelsohn, Weaam Hamed, Declan Chard, Carmen Tur, David MacManus

Eur J Neurol· January 2024

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Finite element analysis of vertebroplasty in the osteoporotic T11-L1 vertebral body: Effects of bone cement formulation.
Subrata Mondal, David B MacManus, Federica Banche-Niclot, Chiara Vitale-Brovarone, Sonia Fiorilli

J Biomed Mater Res B Appl Biomater· January 2024

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A numerical investigation of stress, strain, and bone density changes due to bone remodelling in the talus bone following total ankle arthroplasty.
Subrata Mondal, David B MacManus, Rajesh Ghosh, Abhishek Banagunde, Nicholas Dunne

J Med Eng Technol· January 2024

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Cardiovascular risk factors in secondary progressive multiple sclerosis: A cross-sectional analysis from the MS-STAT2 randomized controlled trial.
Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, David MacManus

Eur J Neurol· September 2023

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A finite element model of contusion spinal cord injury in rodents.
Roman Frantsuzov, Subrata Mondal, Ciara M Walsh, James P Reynolds, Dearbhaile Dooley, David B MacManus

J Mech Behav Biomed Mater· June 2023

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Excision of whole intact mouse brain.
David B MacManus

MethodsX· June 2023

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Micromechanics in biology and medicine.
David B MacManus, Majid Akbarzadeh Khorshidi, Mazdak Ghajari, Hamid M Sedighi

IET Nanobiotechnol· May 2023

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A computational analysis of a novel therapeutic approach combining an advanced medicinal therapeutic device and a fracture fixation assembly for the treatment of osteoporotic fractures: Effects of physiological loading, interface conditions, and fracture fixation materials.
Subrata Mondal, David B MacManus, Amedeo Franco Bonatti, Carmelo De Maria, Kenny Dalgarno

Med Eng Phys· April 2023

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Effect of Uniaxial Compression Frequency on Osteogenic Cell Responses in Dynamic 3D Cultures.
Georgia-Ioanna Kontogianni, Konstantinos Loukelis, Amedeo Franco Bonatti, Elisa Batoni, Carmelo De Maria, David B MacManus

Bioengineering (Basel)· April 2023

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S-duct flow distortion with non-uniform inlet conditions.
Matteo Migliorini, Pavlos K Zachos, David G MacManus, Pierre Haladuda

Proc Inst Mech Eng G J Aerosp Eng· February 2023

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Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, David MacManus

Ann Clin Transl Neurol· October 2022

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Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis.
Alberto Calvi, Ferran Prados Carrasco, Carmen Tur, Declan T Chard, Jonathan Stutters, David MacManus

Neurology· April 2022

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Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study.
Hans-Peter Hartung, Tobias Derfuss, Bruce Ac Cree, Maria Pia Sormani, Krzysztof Selmaj, David MacManus

Mult Scler· March 2022

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Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.
J William L Brown, Nick G Cunniffe, Ferran Prados, Baris Kanber, Joanne L Jones, David MacManus

Lancet Neurol· September 2021

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Mechanical Characterization and Modeling of the Porcine Cerebral Meninges.
Baptiste Pierrat, Louise Carroll, Florence Merle, David B MacManus, Robert Gaul

Front Bioeng Biotechnol· August 2020

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