Publications by authors named "David Machalz"

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Metabolism of the antipsychotic drug olanzapine by CYP3A43.
Jie Zhao, David Machalz, Sijie Liu, Clemens Alexander Wolf, Gerhard Wolber

Xenobiotica· April 2022

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A convenient test system for the identification of CYP4V2 inhibitors.
Shishir Sharma, Sijie Liu, Pradeepraj Durairaj, David Machalz, Gerhard Wolber

Mol Vis· January 2022

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Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase.
Steffen Loke, Anna Stoll, David Machalz, Francesco Botrè, Gerhard Wolber

Front Endocrinol (Lausanne)· December 2021

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Structural insights into understudied human cytochrome P450 enzymes.
David Machalz, Szymon Pach, Marcel Bermudez, Matthias Bureik, Gerhard Wolber

Drug Discov Today· October 2021

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Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor.
David Machalz, Hongjie Li, Wei Du, Shishir Sharma, Sijie Liu

Eur J Med Chem· April 2021

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New Proluciferin Substrates for Human CYP4 Family Enzymes.
Jingyao Liu, David Machalz, Gerhard Wolber, Erik J Sorensen, Matthias Bureik

Appl Biochem Biotechnol· January 2021

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A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota.
Moustafa T Gabr, David Machalz, Szymon Pach, Gerhard Wolber

RSC Med Chem· December 2020

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Functional Expression of All Human Sulfotransferases in Fission Yeast, Assay Development, and Structural Models for Isoforms SULT4A1 and SULT6B1.
Yanan Sun, David Machalz, Gerhard Wolber, Maria Kristina Parr, Matthias Bureik

Biomolecules· November 2020

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Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1.
Wei Du, David Machalz, Qi Yan, Erik J Sorensen, Gerhard Wolber

Biochem Pharmacol· April 2020

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Fine-mapping of the substrate specificity of human steroid 21-hydroxylase (CYP21A2).
Anna Stoll, Steffen Loke, Jan Felix Joseph, David Machalz, Xavier de la Torre

J Steroid Biochem Mol Biol· November 2019

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Functional characterization and mechanistic modeling of the human cytochrome P450 enzyme CYP4A22.
Pradeepraj Durairaj, Linbing Fan, David Machalz, Gerhard Wolber, Matthias Bureik

FEBS Lett· August 2019

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Comparison of the three SARMs RAD-140, GLPG0492 and GSK-2881078 in two different in vitro bioassays, and in an in silico androgen receptor binding assay.
Oliver Zierau, Annika Kolodziejczyk, Günter Vollmer, David Machalz, Gerhard Wolber

J Steroid Biochem Mol Biol· May 2019

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Androgen- and estrogen-receptor mediated activities of 4-hydroxytestosterone, 4-hydroxyandrostenedione and their human metabolites in yeast based assays.
Annekathrin Martina Keiler, Oliver Zierau, Sylvi Wolf, Patrick Diel, Wilhelm Schänzer, David Machalz

Toxicol Lett· August 2018

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A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding.
Fan Yang, David Machalz, Sisi Wang, Zhengyi Li, Gerhard Wolber

FEBS Lett· June 2018

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Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast.
Qi Yan, David Machalz, Andy Zöllner, Erik J Sorensen, Gerhard Wolber

Biochem Pharmacol· December 2017

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