Publications by authors named "David Marcoux"

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Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.
Michael G Yang, Myra Beaudoin-Bertrand, Zili Xiao, David Marcoux, Carolyn A Weigelt

J Med Chem· March 2021

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Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores.
Jade McDaniel, Christopher A Farley, Antonio Ramirez, Bhupinder Sandhu, Amy Sarjeant, David Marcoux

Org Lett· January 2021

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Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization.
Qing Shi, Zili Xiao, Michael G Yang, David Marcoux, Robert J Cherney

Bioorg Med Chem Lett· December 2020

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Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists.
David Marcoux, Myra Beaudoin Bertrand, Carolyn A Weigelt, Shiuhang Yip, Michael Galella

Bioorg Med Chem Lett· October 2020

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Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P) Modulators: Optimization of the PK, PD, and Safety Profiles.
Zili Xiao, Michael G Yang, T G Murali Dhar, Hai-Yun Xiao, John L Gilmore, David Marcoux

ACS Med Chem Lett· September 2020

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Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.
Robert J Cherney, Lyndon A M Cornelius, Anurag Srivastava, Carolyn A Weigelt, David Marcoux

ACS Med Chem Lett· June 2020

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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
David Marcoux, James J-W Duan, Qing Shi, Robert J Cherney, Anurag S Srivastava

J Med Chem· November 2019

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One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent.
Qing Shi, Nathaniel S Greenwood, Mariah C Meehan, Hyunsoo Park, Michael Galella, David Marcoux

Org Lett· November 2019

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Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents.
Qing Shi, Mariah C Meehan, Michael Galella, Hyunsoo Park, Purnima Khandelwal, David Marcoux

Org Lett· January 2018

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Identification of highly potent and selective PI3Kδ inhibitors.
David Marcoux, Lan-Ying Qin, Zheming Ruan, Qing Shi, Qian Ruan

Bioorg Med Chem Lett· July 2017

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Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
Qingjie Liu, Qing Shi, David Marcoux, Douglas G Batt, Lyndon Cornelius

J Med Chem· June 2017

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Identification of potent tricyclic prodrug S1P receptor modulators.
David Marcoux, Hai-Yun Xiao, T G Murali Dhar, Jenny Xie, Lois D Lehman-McKeeman

Medchemcomm· April 2017

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Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P Receptor Modulator.
Michael G Yang, Zili Xiao, T G Murali Dhar, Hai-Yun Xiao, John L Gilmore, David Marcoux

J Med Chem· December 2016

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Effect of counterion structure on rates and diastereoselectivities in α,β-unsaturated iminium-ion Diels-Alder reactions.
David Marcoux, Pascal Bindschädler, Alexander W H Speed, Anna Chiu, Joseph E Pero

Org Lett· July 2011

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Use of achiral additives to increase the stereoselectivity in Rh(II)-catalyzed cyclopropanations.
David Marcoux, Vincent N G Lindsay, André B Charette

Chem Commun (Camb)· February 2010

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trans-Directing ability of the amide group: enabling the enantiocontrol in the synthesis of 1,1-dicarboxy cyclopropanes. Reaction development, scope, and synthetic applications.
David Marcoux, Sébastien R Goudreau, André B Charette

J Org Chem· December 2009

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TfNH2 as achiral hydrogen-bond donor additive to enhance the selectivity of a transition metal catalyzed reaction. Highly enantio- and diastereoselective rhodium-catalyzed cyclopropanation of alkenes using alpha-cyano diazoacetamide.
David Marcoux, Soula Azzi, André B Charette

J Am Chem Soc· May 2009

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General method for the synthesis of phenyliodonium ylides from malonate esters: easy access to 1,1-cyclopropane diesters.
Sébastien R Goudreau, David Marcoux, André B Charette

J Org Chem· January 2009

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trans-Directing ability of amide groups in cyclopropanation: application to the asymmetric cyclopropanation of alkenes with diazo reagents bearing two carboxy groups.
David Marcoux, André B Charette

Angew Chem Int Ed Engl· January 2009

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Palladium-catalyzed synthesis of functionalized tetraarylphosphonium salts.
David Marcoux, André B Charette

J Org Chem· January 2008

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Tetraarylphosphonium salts as soluble supports for the synthesis of small molecules.
Federica Stazi, David Marcoux, Jean-Christophe Poupon, Daniel Latassa, André B Charette

Angew Chem Int Ed Engl· September 2007

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Removal, recovery, and recycling of triarylphosphonium-supported tin reagents for various organic transformations.
Jean-Christophe Poupon, David Marcoux, Jean-Manuel Cloarec, André B Charette

Org Lett· August 2007

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Angiographic selective methylene blue staining of an occult small-bowel arteriovenous malformation.
Steven Schechter, Douglas Deorchis, James Bass, David A Marcoux

Am Surg· January 2002

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