Publications by authors named "David Margolin"

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CVN424, a GPR6 inverse agonist, for Parkinson's disease and motor fluctuations: a double-blind, randomized, phase 2 trial.
Nicola L Brice, Mark Carlton, David H Margolin, Martin Bexon, Kim L Matthews

EClinicalMedicine· November 2024

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Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies.
Colin M Dayan, Beatriz Lecumberri, Ilaria Muller, Sashiananthan Ganesananthan, Samuel F Hunter, David H Margolin

Mult Scler J Exp Transl Clin· January 2023

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A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for Parkinson's Disease.
David H Margolin, Nicola L Brice, Antonia M Davidson, Kim L Matthews, Mark B L Carlton

J Pharmacol Exp Ther· April 2022

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Are the current colonoscopy recommendations for interval surveillance in patients with polyps enough? Machine learning-augmented propensity score cohort analysis of 1840 patients.
Sarah Baker, Dominique J Monlezun, Nicole Wieghard, Charles Whitlow, David Margolin

Surg Endosc· February 2022

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Mismatch negativity as an index of target engagement for excitation/inhibition-based treatment development: a double-blind, placebo-controlled, randomized, single-dose cross-over study of the serotonin type-3 receptor antagonist CVN058.
Pejman Sehatpour, Daniel C Javitt, Heloise M De Baun, Marlene Carlson, Anna Beloborodova, David H Margolin

Neuropsychopharmacology· February 2022

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Anastomotic Leak is Increased With Infection After Colectomy: Machine Learning-Augmented Propensity Score Modified Analysis of 46 735 Patients.
Sarah E Baker, Dominique J Monlezun, Wayne L Ambroze, David A Margolin

Am Surg· January 2022

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Caveolin-1-driven membrane remodelling regulates hnRNPK-mediated exosomal microRNA sorting in cancer.
Harley Robinson, Jayde E Ruelcke, Amanda Lewis, Charles S Bond, Archa H Fox, David Margolin

Clin Transl Med· April 2021

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Efficacy and safety of alemtuzumab over 6 years: final results of the 4-year CARE-MS extension trial.
Alasdair J Coles, Douglas L Arnold, Ann D Bass, Aaron L Boster, D Alastair S Compston, David H Margolin

Ther Adv Neurol Disord· April 2021

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Proportion of alemtuzumab-treated patients converting from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis over 6 years.
Dana Horáková, Aaron Boster, Antonio Bertolotto, Mark S Freedman, Isabel Firmino, David H Margolin

Mult Scler J Exp Transl Clin· December 2020

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Efficacy of alemtuzumab over 6 years in relapsing-remitting multiple sclerosis patients who relapsed between courses 1 and 2: Post hoc analysis of the CARE-MS studies.
Bart Van Wijmeersch, Barry A Singer, Aaron Boster, Simon Broadley, Óscar Fernández, David H Margolin

Mult Scler· November 2020

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Impact of alemtuzumab on health-related quality of life over 6 years in CARE-MS II trial extension patients with relapsing-remitting multiple sclerosis.
Rafael Arroyo, Denise P Bury, Jennifer D Guo, David H Margolin, Maria Melanson

Mult Scler· July 2020

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Modified Frailty Index Predicts Postoperative Outcomes in Patients Undergoing Radical Pelvic Surgery.
Shannon L McChesney, Daniel J Canter, Dominique J Monlezun, Heather Green, David A Margolin

Am Surg· February 2020

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Immune thrombocytopenia in alemtuzumab-treated MS patients: Incidence, detection, and management.
Adam Cuker, Ann D Bass, Congor Nadj, Mark A Agius, Brian Steingo, David H Margolin

Mult Scler· January 2020

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CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin.
Yaowu He, Claire M Davies, Brittney S Harrington, Linh Hellmers, Yonghua Sheng, David Margolin

Oncogene· January 2020

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Infection risk with alemtuzumab decreases over time: pooled analysis of 6-year data from the CAMMS223, CARE-MS I, and CARE-MS II studies and the CAMMS03409 extension study.
Sibyl Wray, Eva Havrdova, David R Snydman, Douglas L Arnold, Jeffrey A Cohen, David H Margolin

Mult Scler· October 2019

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Incidence, management, and outcomes of autoimmune nephropathies following alemtuzumab treatment in patients with multiple sclerosis.
Richard Phelps, Jonathan A Winston, Daniel Wynn, Mario Habek, Hans-Peter Hartung, David H Margolin

Mult Scler· August 2019

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Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis.
Ravan Moret, Linh Hellmers, Xin Zhang, Jessie Gills, Nathan Hite, David A Margolin

J Vis Exp· May 2019

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The Role of Bowel Preparation in Colorectal Surgery: Results of the 2012-2015 ACS-NSQIP Data.
Aaron L Klinger, Heather Green, Dominique J Monlezun, David Beck, Brian Kann, David Margolin

Ann Surg· April 2019

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Disease-free Survival and Local Recurrence for Laparoscopic Resection Compared With Open Resection of Stage II to III Rectal Cancer: Follow-up Results of the ACOSOG Z6051 Randomized Controlled Trial.
James Fleshman, Megan E Branda, Daniel J Sargent, Anne Marie Boller, Virgilio V George, David A Margolin

Ann Surg· April 2019

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Impact of a Novel Surgical Wound Protection Device on Observed versus Expected Surgical Site Infection Rates after Colectomy Using the National Surgical Quality Improvement Program Risk Calculator.
Harry T Papaconstantinou, Elisa H Birnbaum, Rocco Ricciardi, David A Margolin, Robert C Moesinger

Surg Infect (Larchmt)· January 2019

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A Novel Wound Retractor Combining Continuous Irrigation and Barrier Protection Reduces Incisional Contamination in Colorectal Surgery.
Harry T Papaconstantinou, Rocco Ricciardi, David A Margolin, Roberto Bergamaschi, Robert C Moesinger

World J Surg· September 2018

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Clopidogrel bisulfate (Plavix) does not increase bleeding complications in patients undergoing rubber band ligation for symptomatic hemorrhoids.
Nathan Hite, Aaron L Klinger, Peter Miller, David E Beck, Charles B Whitlow, David A Margolin

J Surg Res· September 2018

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An Optimal Orthotopic Mouse Model for Human Colorectal Cancer Primary Tumor Growth and Spontaneous Metastasis.
Nathan Hite, Aaron Klinger, Linh Hellmers, Grace A Maresh, Peter E Miller, David A Margolin

Dis Colon Rectum· June 2018

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SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer.
Ziling Fang, Bo Cao, Jun-Ming Liao, Jun Deng, Kevin D Plummer, David Margolin

Elife· March 2018

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Morbidity Following Coloanal Anastomosis: A Comparison of Colonic J-Pouch vs Straight Anastomosis.
Shaun Brown, David A Margolin, Laura K Altom, Heather Green, David E Beck

Dis Colon Rectum· February 2018

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