Publications by authors named "David O Ferguson"

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Differential expression of a disease-associated MRE11 variant reveals distinct phenotypic outcomes.
McKenna B DeFoer, Ahmed M Mostafa, Andrea J Hartlerode, Steven K Orban, Keegan McDonough, Brianna K L Ferguson, David O Ferguson

Hum Mol Genet· November 2025

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Differential expression of a disease-associated variant reveals distinct phenotypic outcomes.
McKenna B DeFoer, Ahmed M Mostafa, Andrea J Hartlerode, Steven K Orban, Keegan McDonough, Brianna K L Ferguson, David O Ferguson

bioRxiv· July 2025

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Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder.
Andrea J Hartlerode, Ahmed M Mostafa, Steven K Orban, Rachel Benedeck, Koral Campbell, David O Ferguson

Hum Mol Genet· September 2024

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The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons.
Mingmei Ding, Xiaobing Qing, Guangyu Zhang, Carolin Baade-Büttner, Ralph Gruber, David O Ferguson

Front Aging Neurosci· January 2022

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Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution.
Yinghua Li, Bo Li, Wei Li, Yuan Wang, Seçkin Akgül, David O Ferguson

Nat Commun· July 2020

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Reversible mislocalization of a disease-associated MRE11 splice variant product.
Andrea J Hartlerode, Joshua A Regal, David O Ferguson

Sci Rep· July 2018

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MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.
Elizabeth Spehalski, Kayla M Capper, Cheryl J Smith, Mary J Morgan, Maria Dinkelmann, David O Ferguson

Cancer Res· October 2017

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Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.
Andrea J Hartlerode, Mary J Morgan, Yipin Wu, Jeffrey Buis, David O Ferguson

Nat Struct Mol Biol· September 2015

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Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.
Morgan Jones, Gail Osawa, Joshua A Regal, Daniel N Weinberg, James Taggart, David O Ferguson

J Clin Invest· January 2014

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Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.
Joshua A Regal, Todd A Festerling, Jeffrey M Buis, David O Ferguson

Hum Mol Genet· December 2013

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A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.
Hong Xiao, Zhigang Yu, Yipin Wu, John Nan, Diane E Merry, David O Ferguson

Hum Mol Genet· October 2012

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Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus.
Elizabeth Spehalski, Alexander L Kovalchuk, John T Collins, Genqing Liang, Wendy Dubois, David O Ferguson

Proc Natl Acad Sci U S A· August 2012

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The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.
Zhenbao Yu, Gillian Vogel, Yan Coulombe, Danielle Dubeau, Elizabeth Spehalski, David O Ferguson

Cell Res· February 2012

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Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
Jeffrey Buis, Trina Stoneham, Elizabeth Spehalski, David O Ferguson

Nat Struct Mol Biol· January 2012

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Chfr and RNF8 synergistically regulate ATM activation.
Jiaxue Wu, Yibin Chen, Lin-Yu Lu, Yipin Wu, Michelle T Paulsen, David O Ferguson

Nat Struct Mol Biol· June 2011

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Multiple roles for MRE11 at uncapped telomeres.
Yibin Deng, Xiaolan Guo, David O Ferguson, Sandy Chang

Nature· August 2009

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Multiple functions of MRN in end-joining pathways during isotype class switching.
Maria Dinkelmann, Elizabeth Spehalski, Trina Stoneham, Jeffrey Buis, Yipin Wu, David O Ferguson

Nat Struct Mol Biol· August 2009

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Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.
Tobias Else, Alessia Trovato, Alex C Kim, Yipin Wu, David O Ferguson

Cancer Cell· June 2009

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Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.
William Giblin, Monalisa Chatterji, Gerwin Westfield, Tehmina Masud, Brian Theisen, David O Ferguson

Blood· March 2009

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Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.
Jeffrey Buis, Yipin Wu, Yibin Deng, Jennifer Leddon, Gerwin Westfield, David O Ferguson

Cell· October 2008

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Tpp1/Acd maintains genomic stability through a complex role in telomere protection.
Tobias Else, Brian K Theisen, Yipin Wu, Janna E Hutz, Catherine E Keegan, David O Ferguson

Chromosome Res· April 2008

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Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.
Takao Hinoi, Aytekin Akyol, Brian K Theisen, David O Ferguson, Joel K Greenson

Cancer Res· October 2007

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A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes.
Silvia V Diaz-Perez, David O Ferguson, Chen Wang, Gyorgyi Csankovszki, Chengming Wang

Genetics· November 2006

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Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.
Rhine R Shen, David O Ferguson, Mathilde Renard, Katrina K Hoyer, Unkyu Kim

Blood· September 2006

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.
Omer H Yilmaz, Riccardo Valdez, Brian K Theisen, Wei Guo, David O Ferguson

Nature· May 2006

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