Publications by authors named "David P Labbe"

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High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.
David P Labbé, Giorgia Zadra, Meng Yang, Jaime M Reyes, Charles Y Lin, Stefano Cacciatore, Ericka M Ebot, Amanda L Creech, Francesca Giunchi, Michelangelo Fiorentino

Nat Commun· September 2019

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Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications.
Luisa Bacca, Julian Brandariz, Francesca Zacchi, Andrea Zivi, Joaquin Mateo

Gene· November 2025

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Biological responses during high-dose protein nutrition in the critically ill: a randomized controlled trial.
Arnold S Kristof, Mengyin Hong, Nadia Boufaied, Nihad Tousson-Abouelazm, Surya Dandamudi

Am J Clin Nutr· August 2025

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EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
Beatriz German, Katherine L Morel, Teia Noel, Nadia Boufaied, Deborah L Burkhart, David P Labbe

bioRxiv· August 2025

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EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
Beatriz German, Katherine L Morel, Teia Noel, Nadia Boufaied, Deborah L Burkhart, David P Labbe

Res Sq· August 2025

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Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer.
Nadia Boufaied, Paolo Chetta, Tarek Hallal, Stefano Cacciatore, Daniela Lalli

Cancer Res· June 2024

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The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids.
Gabriel Lachance, Karine Robitaille, Jalal Laaraj, Nikunj Gevariya, Thibault V Varin

Nat Commun· April 2024

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CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis.
Yi He, Marie-Anne Goyette, Jennifer Chapelle, Nadia Boufaied, Jalal Al Rahbani

Cell Rep· August 2023

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Thermoneutrality and severe malaria: investigating the effect of warmer environmental temperatures on the inflammatory response and disease progression.
Fiorella Vialard, Isabelle Allaeys, George Dong, Minh Phuong Phan, Urvashi Singh

Front Immunol· June 2023

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SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation.
Md Gulam Musawwir Khan, Nadia Boufaied, Mehdi Yeganeh, Rajani Kandhi, Stephanie Petkiewicz

Cancers (Basel)· January 2023

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To bind or not to bind: Cistromic reprogramming in prostate cancer.
Michelle Shen, Léa-Kristine Demers, Swneke D Bailey, David P Labbé

Front Oncol· September 2022

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The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?
Carole Luthold, Tarek Hallal, David P Labbé, François Bordeleau

Cancers (Basel)· June 2022

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MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets.
Xintao Qiu, Nadia Boufaied, Tarek Hallal, Avery Feit, Anna de Polo

Nat Commun· May 2022

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Response to supraphysiological testosterone is predicted by a distinct androgen receptor cistrome.
Xintao Qiu, Lisha G Brown, Jennifer L Conner, Holly M Nguyen, Nadia Boufaied

JCI Insight· May 2022

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Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy.
Gérald Coulis, Avinash D Londhe, R Sudheer Sagabala, Yanfen Shi, David P Labbé

Sci Signal· April 2022

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CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis.
Chahat Mehra, Ji-Hyun Chung, Yi He, Mónica Lara-Márquez, Marie-Anne Goyette

Commun Biol· September 2021

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Diet-Dependent Metabolic Regulation of DNA Double-Strand Break Repair in Cancer: More Choices on the Menu.
Anna de Polo, David P Labbé

Cancer Prev Res (Phila)· April 2021

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EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer.
Katherine L Morel, Anjali V Sheahan, Deborah L Burkhart, Sylvan C Baca, Nadia Boufaied

Nat Cancer· April 2021

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Evidence that EZH2 Deregulation is an Actionable Therapeutic Target for Prevention of Prostate Cancer.
Deborah L Burkhart, Katherine L Morel, Kristine M Wadosky, David P Labbé, Phillip M Galbo

Cancer Prev Res (Phila)· December 2020

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Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.
Dominique Trudel, Luminita-Mihaela Avarvarei, Michèle Orain, Stéphane Turcotte, Marie Plante

Pathol Res Pract· June 2019

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Transcriptional Regulation in Prostate Cancer.
David P Labbé, Myles Brown

Cold Spring Harb Perspect Med· November 2018

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Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer.
Ericka M Ebot, Travis Gerke, David P Labbé, Jennifer A Sinnott, Giorgia Zadra

Cancer· November 2017

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TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup.
David P Labbé, Christopher J Sweeney, Myles Brown, Phillip Galbo, Spencer Rosario

Clin Cancer Res· November 2017

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Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.
Sheng Yu Ku, Spencer Rosario, Yanqing Wang, Ping Mu, Mukund Seshadri

Science· January 2017

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ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.
Geneviève Deblois, Harvey W Smith, Ingrid S Tam, Simon-Pierre Gravel, Maxime Caron

Nat Commun· July 2016

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