Nat Commun September 2019 PMID 31554818

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.

David P Labbé, Giorgia Zadra, Meng Yang, Jaime M Reyes, Charles Y Lin, Stefano Cacciatore, Ericka M Ebot, Amanda L Creech, Francesca Giunchi, Michelangelo Fiorentino, Habiba Elfandy, Sudeepa Syamala, Edward D Karoly, Mohammed Alshalalfa, Nicholas Erho

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Peak: 37 in Sep 2019

across 5 sources since Sep 2019

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Several discussions reiterate the importance of the article, stating phrases like 'Great paper!' and referencing aspects of the research that challenge dietary norms. Posts also raise awareness about the broader societal implications, particularly in relation to cultural dietary habits, showing concern by mentioning diets' unhealthy aspects with statements like 'no wonder... by tradition culture and poverty.' This choice of words and reflections contribute to a deeper engagement with the research, suggesting a strong collective interest in further understanding the implications of dietary choices on health.

AgreementStrong agreement

The majority of discussions show enthusiasm for the findings, highlighting agreement with the article's conclusions about the high-fat diet's role in cancer progression.

InterestHigh interest

Participants express strong curiosity about the implications of the research, indicating it resonates within related health discussions.

EngagementModerate engagement

While many users share the publication straightforwardly, there are instances of deeper discussion about dietary implications and cancer treatment strategies.

ImpactHigh impact

Many contributors perceive this research as a significant addition to cancer research, emphasizing its relevance for dietary choices and health.

Abstract in brief

Increased consumption of saturated fat and obesity are linked to a higher risk of prostate cancer progression and mortality, but the reasons behind this connection are not well understood.*
Research using a mouse model shows that a high-fat diet enhances the MYC gene's activity, promoting tumor growth by altering metabolism and reducing certain histone modifications.*
A shift from a high-fat diet to a low-fat one can reduce the aggressive MYC signature in tumors, suggesting dietary changes could be a potential treatment strategy for prostate cancer.*

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Impact of High-Fat Diets on Prostate Cancer Progression

This video discusses the link between high-fat diets, obesity, and prostate cancer progression, emphasizing how increased saturated fat consumption can enhance tumor growth by altering metabolism. It explores potential…

Tanima Saha · Jul 23, 2025 74 views

George Mentz JD MBA CWM

@GeorgeMentz · X

RT @GeorgeMentz: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/ZxO…

Apr 5, 2021 · 1 share · 156,742 followers View post →

George Mentz JD MBA CWM

@GeorgeMentz · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/ZxOMAw1KU0

Apr 4, 2021 · 1 share · 156,742 followers View post →

Dr Lisa K Philp

@LisaKPhilp1 · X

Great paper! High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/dtbRJTnrdP

May 27, 2020 · 440 followers View post →

Maribel Hernandez Alvarez

@Maribel_h_a · X

RT @Brunorm84: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program @NatureComms https…

Apr 24, 2020 · 1 share · 272 followers View post →

Bruno Ramos-Molina, PhD

@Brunorm84 · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program @NatureComms https://t.co/6FOWLArL9w

Apr 24, 2020 · 10 likes · 1 share · 6,438 followers View post →

Paperbirds_Oncology

@PaperbirdsO · X

New article: Re: High-Fat Diet Fuels Prostate Cancer Progression by Rewiring the Metabolome and Amplifying the MYC Program. https://t.co/cO9XKp4BOC #prostatecancer #oncology

Feb 20, 2020 · 892 followers View post →

Darsh Bhatia

@DarshuBhatia · X

RT @ImtiazMadmood: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program. High fat, hi…

Dec 3, 2019 · 1 share · 1,130 followers View post →

Imtiaz Mahmood

@ImtiazMadmood · X

Dec 3, 2019 · 9 likes · 1 share · 416,823 followers View post →

Bettie Garcon

@garcon_bettie · X

RT @JeanGaston3: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/3bS…

Dec 1, 2019 · 1 share · 5,764 followers View post →

Jean Gaston

@JeanGaston3 · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/3bSy8wh6oh

Nov 30, 2019 · 1 like · 1 share · 79 followers View post →

Ariakas Enoreth

@Aenoreth · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/hu3lYPGmTS

Nov 30, 2019 · 1,007 followers View post →

Science news

@UpdateonScience · X

https://t.co/jy4Y8A7xn7 High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program #sciencenews https://t.co/IfOGqN6P0i

Nov 29, 2019 · 1,883 followers View post →

localhostscience

@localhostsci · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Nov 29, 2019 · 35 followers View post →

⚡️YOU SCIENCE ⚡️

@YouScienceLIVE · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program via /r/science https://t.co/9l27xNTVp2

Nov 29, 2019 · 1,020 followers View post →

Lydia Maria Fanfan

@LydiaMFanfan · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Oct 11, 2019 · 36 shares · 1,772 followers View post →

CancerPatient POV

@CancrPatientPOV · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Oct 2, 2019 · 36 shares · 1,474 followers View post →

Siddharth Sah

@siddharthksah · X

RT @MrJeffKarp: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/t2rB…

Oct 1, 2019 · 3 shares · 91 followers View post →

Ariakas Enoreth

@Aenoreth · X

RT @MrJeffKarp: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/t2rB…

Oct 1, 2019 · 3 shares · 1,007 followers View post →

Jeff Karp (Pronouns: he/him/his)

@MrJeffKarp · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program https://t.co/t2rBNSWzX6

Oct 1, 2019 · 4 likes · 3 shares · 4,022 followers View post →

Mimi_ Cardio

@mimi_cardio · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 28, 2019 · 36 shares · 188 followers View post →

Warwick Dunn

@rickdunnblade · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 28, 2019 · 36 shares · 2,508 followers View post →

Michael Buratovich

@MichaelBuratovi · X

RT @Brunorm84: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program @NatureComms https…

Sep 27, 2019 · 1 share · 1,166 followers View post →

Prostate Network

@ProstateNetwork · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 1,856 followers View post →

Barrie Peck - TCM Lab

@_barriepeck · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 636 followers View post →

Rutter Lab

@RutterLab · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 8,732 followers View post →

Dr. Biswapriya Misra

@BiswapriyaMisra · X

RT @GioIsNow: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Communicat…

Sep 27, 2019 · 1 share · 5,763 followers View post →

David DeGraff

@DavidDeGraff5 · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 716 followers View post →

Gio Rodriguez Blanco

@GioIsNow · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Communications https://t.co/x0flNzgEH7

Sep 27, 2019 · 3 likes · 1 share · 521 followers View post →

Leprivier Lab "Stress responses and cancer"

@AGLeprivier · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 236 followers View post →

MaheshIddawela MBBS, PhD

@MaheshIddawela · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 427 followers View post →

Bruno Ramos-Molina, PhD

@Brunorm84 · X

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program @NatureComms https://t.co/6FOWLAa9KW

Sep 27, 2019 · 5 likes · 1 share · 6,438 followers View post →

DCU Cancer Research

@DCU_Cancer · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 191 followers View post →

FrezzaLab

@FrezzaLab · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 26,989 followers View post →

Elad Sharon

@EladSharonMD · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 3,847 followers View post →

Filippo Pederzoli

@Pederfizzo · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 294 followers View post →

Sriganesh Srihari | Biomedical Data Science

@srigsri23 · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 2,085 followers View post →

Arlou Angeles

@arlouangeles · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 9 followers View post →

Manojit Swamynathan

@manojit_ms · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 27, 2019 · 36 shares · 477 followers View post →

Hsieh Lab

@HsiehLab · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 1,923 followers View post →

Dhruv Gupta

@DhruvGupta_2 · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 24 followers View post →

Elai Davicioni

@Davicioni · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 632 followers View post →

Reza A. Ghodsi

@ReGhodsi · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 259 followers View post →

Julien Dagenais

@dagenais_julien · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 117 followers View post →

Mike

@mfphotograph · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 1,071 followers View post →

ShengYu Ku

@ShengyuKu · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 273 followers View post →

David Russler-Germain, MD/PhD

@dgermain21 · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 3,666 followers View post →

Stephan Clavel

@ClavelStephan · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 208 followers View post →

Piet Ost

@piet_ost · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 4,111 followers View post →

Sid Hopps

@DjangoHopps · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 469 followers View post →

Olivier Elemento

@ElementoLab · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 6,251 followers View post →

Victoria Hendry

@HendryVictoria · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 1,323 followers View post →

PCF Science

@PCF_Science · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 5,355 followers View post →

David Olmos

@Dolmos77 · X

RT @drleighellis: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program | Nature Commun…

Sep 26, 2019 · 36 shares · 1,223 followers View post →

EllisLab_

@EllisLab_ · X

Sep 26, 2019 · 92 likes · 36 shares · 3,961 followers View post →

@geginegi · X

RT @oxkawa: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program 脂っこい食べ物を食べるとMycの発現が増…

Sep 25, 2019 · 1 share · 907 followers View post →

Kato

@oxkawaka · X

Sep 25, 2019 · 9 likes · 1 share · 5,824 followers View post →

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.

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Impact of High-Fat Diets on Prostate Cancer Progression