Publications by authors named "David Perlmutter"

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Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?
Richard J Johnson, Dean R Tolan, Dale Bredesen, Maria Nagel, Laura G Sánchez-Lozada, Mehdi Fini, Scott Burtis, Miguel A Lanaspa, David Perlmutter

Am J Clin Nutr· March 2023

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Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons.
Eva Klinman, Ji-Sun Kwon, Roland E Dolle, Stephen C Pak, Gary A Silverman, David H Perlmutter

bioRxiv· October 2025

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"I don't let anybody die on my watch": perspectives on the intersection of community overdose response and emergency medical services among people who use drugs in Seattle, WA.
Courteney Wettemann, David L Perlmutter, Tessa Frohe, Taylor Ryan, Grover Will Williams

Harm Reduct J· March 2025

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"You might be nice, but where you take me, they're not gonna be": Preferences for field-based post-overdose interventions.
Jenna van Draanen, Addy Adwell, Courteney Wettemann, Callan Elswick Fockele, Brenda Goh, David L Perlmutter

Drug Alcohol Rev· November 2024

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Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency.
Edgar N Tafaleng, Jie Li, Yan Wang, Tunda Hidvegi, Alex Soto-Gutierrez, David H Perlmutter

Hepatology· October 2024

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Harm Reduction in the Field: First Responders' Perceptions of Opioid Overdose Interventions.
Callan Elswick Fockele, Tessa Frohe, Owen McBride, David L Perlmutter, Brenda Goh

West J Emerg Med· July 2024

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A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during post-embryonic development and identifies compounds that modulate autophagy.
Zachary D Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, David H Perlmutter

Autophagy Rep· July 2024

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Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency.
Jie Li, Francesca Moretti, Tunda Hidvegi, Sanja Sviben, James A J Fitzpatrick, David H Perlmutter

Cell Mol Gastroenterol Hepatol· May 2024

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Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration.
Seong Won Lee, Young Mi Oh, Matheus B Victor, Yan Yang, Shawei Chen, David H Perlmutter

Nat Aging· January 2024

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"Another tool in the toolkit"-Perceptions, suggestions, and concerns of emergency service providers about the implementation of a supervised consumption site.
David Perlmutter, Courteney Wettemann, Callan Elswick Fockele, Tessa Frohe, Will Williams

Int J Drug Policy· May 2023

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Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington's disease.
Seong Won Lee, Young Mi Oh, Matheus B Victor, Ilya Strunilin, Shawei Chen, David H Perlmutter

Res Sq· May 2023

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Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency.
Yanfeng Li, Chandan Guha, Patrik Asp, Xia Wang, Tatyana L Tchaikovskya, David H Perlmutter

Hepatol Commun· March 2023

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Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy.
Young Mi Oh, Seong Won Lee, Woo Kyung Kim, Shawei Chen, Victoria A Church, David H Perlmutter

Nat Neurosci· November 2022

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Investing in the Advancement of Science.
David H Perlmutter

Mo Med· November 2022

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Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z.
David A Rudnick, Jiansheng Huang, Tunda Hidvegi, Andrew S Chu, Pamela Hale, David H Perlmutter

Gastroenterology· July 2022

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Assessing civility at an academic health science center: Implications for employee satisfaction and well-being.
Lisa A Campbell, Jenna R LaFreniere, Mhd Hasan Almekdash, David D Perlmutter, Huaxin Song

PLoS One· August 2021

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Real-time jitter correction in a photonic analog-to-digital converter.
Joshua Olson, David S Perlmutter, Peter T S DeVore, Jason T Chou

Opt Lett· September 2020

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Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis.
Qingya Shi, Fen Pei, Gary A Silverman, Stephen C Pak, David H Perlmutter

Int J Mol Sci· April 2020

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An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z.
Yan Wang, Murat C Cobanoglu, Jie Li, Tunda Hidvegi, Pamela Hale, David H Perlmutter

PLoS One· November 2019

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Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome.
John-Paul Berauer, Anya I Mezina, David T Okou, Aniko Sabo, Donna M Muzny, David H Perlmutter

Hepatology· September 2019

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NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms.
Amitava Mukherjee, Tunda Hidvegi, Patrick Araya, Michael Ewing, Donna B Stolz, David H Perlmutter

Cell Death Differ· March 2019

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Preventing Alzheimer's Disease.
David Perlmutter

J Am Coll Nutr· September 2018

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Posterior column reconstruction improves fusion rates at the level of osteotomy in three-column posterior-based osteotomies.
Stephen J Lewis, Chandan Mohanty, Aaron M Gazendam, So Kato, Sam G Keshen, David Perlmutter

Eur Spine J· March 2018

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Quantitative assessment of cell fate decision between autophagy and apoptosis.
Bing Liu, Zoltán N Oltvai, Hülya Bayır, Gary A Silverman, Stephen C Pak, David H Perlmutter

Sci Rep· December 2017

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α1-antitrypsin Deficiency: A Misfolded Secretory Protein Variant with Unique Effects on the Endoplasmic Reticulum.
David H Perlmutter

Endoplasmic Reticulum Stress Dis· September 2016

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