Am J Clin Nutr March 2023 PMID 36774227

Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?

Richard J Johnson, Dean R Tolan, Dale Bredesen, Maria Nagel, Laura G Sánchez-Lozada, Mehdi Fini, Scott Burtis, Miguel A Lanaspa, David Perlmutter

Mentions

140
Peak: 58 in Nov 2023
across 7 sources since Jan 2023

Extended reach

1,075,856
potential audience

Total likes

330

Video views

3,414

Mentions per month

Jan 2023 – Dec 2025

Where it's discussed

  • X / Twitter91 posts
  • Facebook20 posts
  • Reddit14 posts
  • News8 articles
  • YouTube3 videos
  • Instagram3 posts
  • Blogs1 articles

AI synopsis

What people are saying

The overall tone reflects strong agreement and interest, as many comments reference scientific studies and mechanistic pathways, such as increased brain fructose levels and the evolutionary hypothesis. Words like 'worth a read' and phrases like 'references' highlight the community's engagement in understanding the implications, emphasizing a potential paradigm shift in how Alzheimer’s might be approached.

AgreementModerate agreement

Most discussions support the hypothesis, emphasizing the potential link between metabolic pathways and Alzheimer’s disease.

InterestHigh interest

Posts demonstrate high curiosity, referencing detailed studies and encouraging further exploration.

EngagementModerate engagement

Conversations include sharing mechanistic insights and citing research, indicating thoughtful participation.

ImpactModerate impact

The discussions suggest that this idea could influence future research directions and treatment approaches.

Abstract in brief

  • The text explores the idea that Alzheimer's disease might be a result of an evolutionary survival response involving intracerebral fructose and uric acid metabolism, which helps organisms survive food and water scarcity but could become harmful if activated excessively or chronically.
  • When the body processes fructose, it triggers a survival mechanism that increases food and water intake, reduces resting metabolism, and encourages fat and glycogen storage, possibly leading to brain issues like glucose hypometabolism, mitochondrial problems, and inflammation associated with Alzheimer's.
  • The authors suggest that modern diets high in sugar, refined carbs, and salt may overstimulate this survival pathway, turning it maladaptive, and propose that reducing dietary fructose or blocking its metabolism might offer new ways to prevent or treat Alzheimer's disease.]

Top posts

Most liked on X and Bluesky
Nick Norwitz MD PhD
@nicknorwitz · X

Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-axis: fold-increase X-axis: various brain regions, e.g. Hip = Hippocampus See attached Tweet for mechanistic details from new paper https://t.co/N6EC6WQVXe https://t.co/4pu3Tpdk96 https://t.co/AHIquEfa8P

Nov 16, 2023 · 178 likes · 60 shares · 113,599 followers View post →
Agingdoc
@agingdoc1 · X

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?

Feb 14, 2023 · 21 likes · 1 share · 43,167 followers View post →
Dr. Uma Naidoo
@DrUmaNaidoo · X

Reference: Johnson, Richard J., et al. "Could Alzheimer’s Disease Be a Maladaptation of an Evolutionary Survival Pathway Mediated by Intracerebral Fructose and Uric acid Metabolism?." The American Journal of Clinical Nutrition (2023).

Feb 20, 2023 · 14 likes · 2 shares · 12,897 followers View post →
Leticia Kawano-Dourado (I'm on BlueSky/LinkedIn)
@leticiakawano · X

Mar 16, 2024 · 8 likes · 14,578 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?” by Richard J. Johnson et al. American Journal of Clinical Nutrition https://t.co/SvuqnfHUBq

Feb 13, 2023 · 6 likes · 1 share · 506,876 followers View post →
Andreea Nitescu RD MSc
@AndreeaNRD · X

New Rick Johnson review published in the American Journal of Clinical Nutrition "Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?" https://t.co/iAAyV3dt4u Worth a read.

Mar 14, 2023 · 6 likes · 1,304 followers View post →

All mentions

Pattibe
@pattiber1 · X

RT @DavidPerlmutter: Tune in to my episode with Dr. EF Rain on how to prevent Alzheimer's by taking care of your metabolism! https://t.co/Q…

May 26, 2024 · 1 share · 789 followers View post →
David Perlmutter, MD
@DavidPerlmutter · X

Tune in to my episode with Dr. EF Rain on how to prevent Alzheimer's by taking care of your metabolism! https://t.co/QLOvU9AKX2

May 16, 2024 · 3 likes · 1 share · 81,591 followers View post →
N.E.Egecioglu, MD
@EllaAkman · X

Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? - PubMed https://t.co/2K3pL3L2UG

Apr 10, 2024 · 27 followers View post →
Leticia Kawano-Dourado (I'm on BlueSky/LinkedIn)
@leticiakawano · X

Mar 16, 2024 · 8 likes · 14,578 followers View post →
Nutrition Ali
@NutritionAliUK · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 22, 2023 · 60 shares · 2,850 followers View post →
Jennie Hays
@JennieHaysTX · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 18, 2023 · 60 shares · 225 followers View post →
SabineRing
@ring_sabine · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 18, 2023 · 60 shares · 52 followers View post →
keto live
@keto_live · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 18, 2023 · 60 shares · 3,936 followers View post →
WJW Mental Health Legal Fund
@wjwmhlf · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 1,302 followers View post →
1907 Foundation
@1907foundation · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 467 followers View post →
Jeremy Hannan
@bionicsloth_ · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 100 followers View post →
Alvaro Díaz
@LomoLais · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 417 followers View post →
James Tang
@James69888 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 1,612 followers View post →
Algy Goosen
@AlgyGoosen · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 865 followers View post →
frank
@frankwikson · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 26 followers View post →
Christine Cockett
@Hcacockett · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 423 followers View post →
krysia_learner
@krysia_learner · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 241 followers View post →
David Diamond
@LDLSkeptic · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 45,083 followers View post →
Paleossi
@OssiFlowmeow · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 590 followers View post →
Bella
@Liggi_Bella · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 369 followers View post →
#No2Treason
@netzona · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 1,690 followers View post →
artificialFly
@uShallSee · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 9,027 followers View post →
Holly Loves Chows
@ChowsHolly · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 383 followers View post →
Recovered Sugar Addict
@sugarliberated · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 1,068 followers View post →
MovingHouseDJs
@movinghousedjs · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 3,134 followers View post →
DeTank1979
@DTank1979 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 355 followers View post →
Helen Reynolds
@helenreynolds39 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 208 followers View post →
Marc VALLEE
@marcvallee13 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 256 followers View post →
Gregory Leow
@GregoryLeow · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 245 followers View post →
Gospoja
@VirginMary_HR · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 74 followers View post →
Ted Clark
@tedrsa · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 182 followers View post →
Longevity Explorer
@LongevityExplor · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 17, 2023 · 60 shares · 1,672 followers View post →
Gentle Mutt
@GentleMutt · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 792 followers View post →
Kulpable
@Kulpable2 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 147 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 197 followers View post →
John Cripps
@JCrippsSciGuy · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 427 followers View post →
El Cerva
@EliCervantez · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 220 followers View post →
mtbmasaya1, Masaya
@mtbmasaya1 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 755 followers View post →
Debbie Secor
@debbiesecor · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 272 followers View post →
Ryan Tidwell
@RyanTidwellPHC · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 247 followers View post →
Neil Roberts
@Spugspug · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 255 followers View post →
russell wetzel
@undecided95 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 102 followers View post →
Javed Alam
@jalam1001 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 1,011 followers View post →
June
@June52352847 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 109 followers View post →
are we there yet?
@JusticiarsWatch · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 2,410 followers View post →
❤️‍
@GojoDuneMatrix · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 409 followers View post →
kike
@FUENTESMANZULLI · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 249 followers View post →
James
@yxz8 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 173 followers View post →
Sean
@S_Gallagher23 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 1,596 followers View post →
Linda Galliher
@LindaGalliher · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 844 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 332 followers View post →
Prof. Nasser Alzerwi
@NAlzerwi · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 1,760 followers View post →
Deplora-Bill Crowell
@n4hpg · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 5,594 followers View post →
Al Soto
@AlSoto9 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 690 followers View post →
ZKA
@0knowledgeactor · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 1,177 followers View post →
Christopher Dan
@DrChrisDan · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 834 followers View post →
PC ⛓
@PC65049955 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 1,444 followers View post →
BeverlyHansen
@BeverlyBHansen · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 253 followers View post →
Steve Bayes
@stevieb99 · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 730 followers View post →
Mark E. Merritt
@markemerritt · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 845 followers View post →
AnaMuñiz
@megustastarbien · X

RT @nicknorwitz: Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-a…

Nov 16, 2023 · 60 shares · 4,706 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

Fructose levels are increased ~5X in the brains of human patients with #Alzheimers disease as compared to controls Y-axis: fold-increase X-axis: various brain regions, e.g. Hip = Hippocampus See attached Tweet for mechanistic details from new paper https://t.co/N6EC6WQVXe https://t.co/4pu3Tpdk96 https://t.co/AHIquEfa8P

Nov 16, 2023 · 178 likes · 60 shares · 113,599 followers View post →
Carlos Cuernavaca
@CarlosCuerna · X

RT @papayaykware: https://t.co/2vLTpkUXQ3 ¿Podría la enfermedad de Alzheimer ser una mala adaptación de una vía de supervivencia evolutiva…

Jul 22, 2023 · 1 share · 1,547 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/2vLTpkUXQ3 ¿Podría la enfermedad de Alzheimer ser una mala adaptación de una vía de supervivencia evolutiva mediada por la fructosa intracerebral y el metabolismo del ácido úrico? Aquí,revisamos y ampliamos una hipótesis previa de que este mecanismo de supervivencia

Jul 19, 2023 · 2 likes · 1 share · 8,024 followers View post →
Nutrition1974
@Nutrition1974 · X

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? https://t.co/m7NjzTMIv8

Jul 18, 2023 · 307 followers View post →
Free56
@Free5620 · X

https://t.co/gIrHtLkFPv

Jul 2, 2023 · 200 followers View post →
Иван
@iadenisov · X

@e_ebunny Про диабет там это не главное. В целом объясняется про то, что калорийная теория зафейлилась. Правда про фруктозу мало, про неё уже много новых исследований, что она переключает организм в режим выживания, и приводит к отложению жира. Вот отсюда картинка: https://t.co/gUt3eLhRdO https://t.co/IpOOcb4cC1

May 3, 2023 · 1 like · 206 followers View post →
Andreea Nitescu RD MSc
@AndreeaNRD · X

New Rick Johnson review published in the American Journal of Clinical Nutrition "Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?" https://t.co/iAAyV3dt4u Worth a read.

Mar 14, 2023 · 6 likes · 1,304 followers View post →
Dr. Ann
@AnnChildersMD · X

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?https://t.co/0BSVLlOyyh

Feb 25, 2023 · 3 likes · 13,859 followers View post →
CentreForDiabetesCare®️_Jodhpur
@C4DiabetesCare · X

RT @drstak70: Could #Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral #fructose metabol…

Feb 23, 2023 · 1 share · 7 followers View post →
Sandeep Tak MD(AIIMS Delhi), FACE
@drstak70 · X

Could #Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral #fructose metabolism!! @AJCNutrition @docanoopmisra @EASDelearning @drshafikuchay @C4DiabetesCare https://t.co/ptRg39Y9yZ

Feb 23, 2023 · 5 likes · 1 share · 1,764 followers View post →
F.Yusufzai
@obsurfer84 · X

Could Alzheimer’s disease be a maladaptation of an evolutionary surviv... https://t.co/dNS0HEhUqH https://t.co/f9lo6DeOYA

Feb 21, 2023 · 293 followers View post →
中武 壮以知
@soichinakatake · X

果糖(フルクトース)は、動物を飢餓へ備えさせ、その結果、体重が増加し、脂肪とグリコーゲン貯蔵を強化し、インスリン抵抗性、血圧上昇、塩分過敏症、および軽度の全身性炎症が引き起こされる。 Could Alzheimer’s disease be a maladaptation of an evolutionary ... https://t.co/smYYqAKJYP

Feb 20, 2023 · 1 like · 137 followers View post →
Marcia S Newman
@marciasgreen · X

RT @DrUmaNaidoo: Reference: Johnson, Richard J., et al. "Could Alzheimer’s Disease Be a Maladaptation of an Evolutionary Survival Pathway M…

Feb 20, 2023 · 2 shares · 4,961 followers View post →
suchindra
@reachsuchindra · X

RT @DrUmaNaidoo: Reference: Johnson, Richard J., et al. "Could Alzheimer’s Disease Be a Maladaptation of an Evolutionary Survival Pathway M…

Feb 20, 2023 · 2 shares · 11 followers View post →
Dr. Uma Naidoo
@DrUmaNaidoo · X

Reference: Johnson, Richard J., et al. "Could Alzheimer’s Disease Be a Maladaptation of an Evolutionary Survival Pathway Mediated by Intracerebral Fructose and Uric acid Metabolism?." The American Journal of Clinical Nutrition (2023).

Feb 20, 2023 · 14 likes · 2 shares · 12,897 followers View post →
Orlando_uy
@Orlando_uy · X

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? https://t.co/LT782r92hh

Feb 20, 2023 · 695 followers View post →
George Lominadze
@GeorgeLominadze · X

Could Alzheimer’s disease be a maladaptation of an evolutionary surviv... https://t.co/ieEfjLnlI0

Feb 18, 2023 · 105 followers View post →
Coach Wayland | Performance Expert | Craftsman
@WSWayland · X

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? - ScienceDirect https://t.co/jGCmcAQLPZ

Feb 18, 2023 · 2 likes · 15,501 followers View post →
Jon Bischke
@jonbischke · X

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? https://t.co/9bEeUYie9G

Feb 17, 2023 · 6,521 followers View post →
milburn pennybags
@milburnpennyba2 · X

RT @contrariansmind: Could Alzheimer’s disease be a maladaptation of an evolutionary surviv... https://t.co/F8s9OLekHu

Feb 16, 2023 · 1 share · 237 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Could Alzheimer’s disease be a maladaptation of an evolutionary surviv... https://t.co/RU1BLE5oBD https://t.co/RNC12XbxuY

Feb 16, 2023 · 24,009 followers View post →
Jeff Robinson, CEO and Chairman of $MRES and $RLAB
@contrariansmind · X

Could Alzheimer’s disease be a maladaptation of an evolutionary surviv... https://t.co/F8s9OLekHu

Feb 16, 2023 · 1 like · 1 share · 54,762 followers View post →
Mar Alonso Hoyas
@MarMarhoyas · X

RT @NeuroscienceNew: “Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose a…

Feb 15, 2023 · 1 share · 3,653 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric…

Feb 14, 2023 · 1 share · 43,167 followers View post →
Agingdoc
@agingdoc1 · X

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?

Feb 14, 2023 · 21 likes · 1 share · 43,167 followers View post →
Lumosa Therapeutics
@Lumosa__Tx · X

Original research: Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabhttps://www.sciencedirect.com/science/article/pii/S0002916523000047?via%3Dihubolism? Share if you like this article.

Feb 14, 2023 · 680 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?” by Richard J. Johnson et al. American Journal of Clinical Nutrition https://t.co/SvuqnfHUBq

Feb 13, 2023 · 6 likes · 1 share · 506,876 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? - ScienceDirect https://t.co/Ba29zH1dBV

Feb 13, 2023 · 2,566 followers View post →
lolitsjournals
@lolitsjournals · X

Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? https://t.co/eCABWkUq2c

Feb 12, 2023 · 39 followers View post →
Nathan M D'Cunha
@NathanMDCunha · X

Could Alzheimer’s Disease Be a Maladaptation of an Evolutionary Survival Pathway Mediated by Intracerebral Fructose and Uric acid Metabolism? https://t.co/EuRkiiF9oF

Jan 20, 2023 · 2 likes · 1,476 followers View post →
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Am J Clin Nutrit. 2023. doi: 10.1016/j.ajcnut. 2023.01.002 · Może być zdjęciem przedstawiającym 1 osoba i garnitur · Teresa M. Olszak and 17 others ·

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Western diet causes Alzheimer's disease and dementia by ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by many animals and ...

Dec 12, 2025 View →
Übermäßiger Fruktosekonsum: Evolutionärer Vorteil könnte sich ...
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Während Glukose mithilfe von Insulin kontrolliert in jede Körperzelle aufgenommen wird, wird Fruktose fast ausschließlich in der Leber metabolisiert und kann ...

Dec 12, 2025 View →
老年性痴呆专区【11】 - 生物谷
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AJCN:新发现! · JAD:睡眠药物的使用或与机体痴呆症风险的增加直接相关 · Redox Biology: α7nAChR介导线粒体氧化应激来拮抗Aβ诱导的心房重构 · Alzheimers Dement:揭示一种有毒 ...

Dec 12, 2025 View →
Low carb diets reverse alzheimer's and dementia
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Dec 4, 2025 View →
Preventing alzheimer's with diet
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Sep 30, 2025 View →
“I'm glad I'm poor”: Scientists link wealthy-favored superfood to ALS ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Sep 5, 2025 View →
For years, glycogen the body's stored sugar was thought irrelevant ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Aug 26, 2025 View →
Does the sugar industry influence the national conversation about ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Jun 28, 2025 View →
This is wild. A perfectly healthy rat was placed in a pool and was ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results ... Alexander, Damian J. Ruck, and Hillary N. Fouts. “US obesity as ...

Dec 12, 2024 View →
The American diet's link to brain damage and Alzheimer's
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Oct 24, 2024 View →
Interesting idea: "One way to consider the relationships reviewed ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Mar 26, 2024 View →
I need do quit sugar! : r/sugarfree
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... one example of hundreds, this one relating to Alzheimer's: https://doi.org/10.1016/j.ajcnut.2023.01.002 · Thin_Eggplant_4682. • 2y ago.

Sep 22, 2023 View →
Eu já fiz a minha escolha. E você, ainda consumindo adoçantes ...
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Immunity, 2023; DOI: 10.1016/j.immuni ... Author links open overlay panelRichard J. ... ajcnut.2023.01.002 Poderia a doença de ...

Jun 11, 2023 View →
Below is a picture of cross-sections of blood vessels from autopsies ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

May 23, 2023 View →
Is Alzheimer's Disease Driven by Our Foraging Instinct ...
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Am J Clin Nutrit. 2023. doi: 10.1016/j.ajcnut.2023.01.002. This article is a rework of a press release from the University of Colorado ...

Mar 27, 2023 View →
[Article] Could Alzheimer's disease be a maladaptation of an ...
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https://doi.org/10.1016/j.ajcnut.2023.01.002 https://www.sciencedirect.com/science/article/abs/pii/S0002916523000047.

Mar 19, 2023 View →
Patologiczne procesy w układzie nerwowym. Uwaga fruktoza ...
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... 10.1016/j.ajcnut.2023.01.002). „Stawiamy hipotezę, że choroba Alzheimera (AD) jest spowodowana dietą” – mówi główny autor publikacji dr ...

Mar 2, 2023 View →
AJCN:新发现!果糖或会驱动人类阿尔兹海默病的发生!
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DOI:10.1016/j.ajcnut.2023.01.002. 免责声明· 我要投稿. 阿尔兹海默病果糖代谢蛋白. 点赞 19. 打赏. 精彩评论. 打开APP 发表你的想法. 点击查看更多 ...

Mar 1, 2023 View →
Un posible nuevo factor de riesgo para el alzhéimer: la fructosa en ...
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... J. Johnson, Dean R. Tolan, Dale Bredesen, Maria Nagel ... 10.1016/j.ajcnut.2023.01.002. Conforme a los criterios de Logo Trust Project.

Feb 27, 2023 View →
Could Alzheimer's disease be a maladaptation of an evolutionary ...
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... J. Johnson 1 2, Dean R. Tolan 3, Dale ... 10.1016/j.ajcnut.2023.01.002 Poderia a ... J. Johnson 1 2, Dean R. Tolan 3, Dale Bredesen 4 ...

Feb 19, 2023 View →
Frutose pode ser um gatilho para a doença de Alzheimer : r ... - Reddit
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The American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (esse endereço DOI é um link direto para o estudo).

Feb 18, 2023 View →
Fructoza ar putea fi cauza bolii Alzheimer : r/Nootropics - Reddit
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The American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (adresa DOI aia e un link direct către lucrare).

Feb 18, 2023 View →
Fruktoosi voi vauhdittaa Alzheimerin tautia : r/Nootropics - Reddit
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The American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (toi DOI-osoite on suora linkki tutkimukseen).

Feb 18, 2023 View →
果糖可能导致阿尔茨海默病: r/Nootropics
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... 进化生存途径的适应不良?《美国临床营养学杂志》,2023 年;DOI:10.1016/j.ajcnut.2023.01.002. (那个DOI 地址是一个直接指向论文的热链接). [已删除].

Feb 18, 2023 View →
ฟรุกโตสอาจเป็นสาเหตุของโรคอัลไซเมอร์ : r/Nootropics - Reddit
Reddit

... Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (ที่อยู่ DOI นี้เป็นลิงก์โดยตรงไปยังงานวิจัย). โหวตถูกใจ 3 โหวตไม่ถูกใจ แชร์.

Feb 18, 2023 View →
フルクトースがアルツハイマー病を促進する可能性がある : r ... - Reddit
Reddit

The American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (このDOIアドレスは、論文への直接のホットリンクだよ).

Feb 18, 2023 View →
Η φρουκτόζη μπορεί να προκαλέσει τη νόσο του Αλτσχάιμερ : r ...
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... American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (αυτή η διεύθυνση DOI είναι ένα hotlink απευθείας στην εργασία).

Feb 18, 2023 View →
Fruktoz Alzheimer hastalığını tetikleyebilir : r/Nootropics - Reddit
Reddit

The American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (bu DOI adresi doğrudan makaleye bir bağlantıdır).

Feb 18, 2023 View →
A fruktóz Alzheimer-kórt okozhat : r/Nootropics - Reddit
Reddit

The American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (az a DOI cím egy hotlink, ami egyenesen a cikkre mutat).

Feb 18, 2023 View →
Fruktosa boleh jadi punca penyakit Alzheimer : r/Nootropics - Reddit
Reddit

The American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (alamat DOI tu adalah pautan terus ke kertas kerja).

Feb 18, 2023 View →
Fruktose kan drive Alzheimers sykdom : r/Nootropics - Reddit
Reddit

... , 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (den DOI-adressen er en hotlink direkte til papiret). Gi pluss-stemme 3. Stem minus. Del.

Feb 18, 2023 View →
Fructose could drive Alzheimer's disease : r/Nootropics
Reddit

... American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002. (that DOI address is a hotlink directly to the paper). [deleted].

Feb 18, 2023 View →
A role for sugar, high glycemic carbs and salt in Alzheimer's disease ...
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... and salt in Alzheimer's disease. Doi.org/10.1016/j.ajcnut.2023.01.002 #lowcarb #dementia #sugar #alzheimersassociation".

Feb 14, 2023 View →
Fructose may be fueling the formation of Alzheimer's disease
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doi.org/10.1016/j.ajcnut.2023.01.002. Currently rated 4.2 by 5 people. Posted in: Medical Science News | Medical Research News | Medical ...

Feb 13, 2023 View →
Study suggests fructose could drive Alzheimer's disease
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DOI: 10.1016/j.ajcnut.2023.01.002. Journal information: American Journal of Clinical Nutrition. Provided by CU Anschutz Medical Campus. + ...

Feb 13, 2023 View →
Fructose could drive Alzheimer's disease | ScienceDaily
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Richard J. Johnson, Dean R. Tolan, Dale Bredesen ... The American Journal of Clinical Nutrition, 2023; DOI: 10.1016/j.ajcnut.2023.01.002 ...

Feb 13, 2023 View →
Foods like sugary snacks and processed meats increase dementia risk
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Jul 24, 2022 View →
Fruitarians: Primarily feeding on fruits and young leaves
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Dec 24, 2021 View →
OK, it's mouse Alzheimer's, but it's human Amyloid-Beta. And it's ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Sep 17, 2021 View →
huh, want to know more "New research suggests that conditions ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Oct 16, 2020 View →
Alzheimer's disease linked to fructose metabolism
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The American Journal of Clinical Nutrition https: //doi.org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a ...

Sep 24, 2020 View →
#CitizenScientist - Paradigm #3, the new model of Cancer. ...the NIH ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

May 5, 2019 View →
Can food impact memory and Alzheimer's disease?
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Jan 28, 2019 View →
Yo can we get all the things posted please http://www.sciencedirect ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Jan 14, 2018 View →
GLYCOPROTEINS AND THE CASE FOR RAW VEGANISM I found ...
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org/10.1016/j.ajcnut.2023.01.002 “AD [Alzheimer's disease] results from a maladaptation to an evolutionary survival pathway that is used by ...

Jun 7, 2014 View →