Publications by authors named "David R Edgell"

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A buffer-tuning strategy to profile domain-specific activity of chimeric I-TevI/CRISPR gene editors in vitro.
Kurt W Loedige, Alexa L White, Thomas A McMurrough, Brent E Stead, David R Edgell

Sci Rep· November 2025

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Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut.
Gary W Foo, Aathavan S Uruthirapathy, Claire Q Zhang, Izabela Z Batko, David E Heinrichs, David R Edgell

ACS Synth Biol· September 2025

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Ku limits RNA-induced innate immunity to allow Alu expansion in primates.
Yimeng Zhu, Angelina Li, Suvrajit Maji, Brian J Lee, Sophie M Korn, David R Edgell

Nature· July 2025

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Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion.
Yimeng Zhu, Angelina Li, Suvrajit Maji, Brian J Lee, Sophie M Korn, David R Edgell

bioRxiv· February 2025

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Intein-based thermoregulated meganucleases for containment of genetic material.
Gary W Foo, Christopher D Leichthammer, Ibrahim M Saita, Nicholas D Lukas, Izabela Z Batko, David R Edgell

Nucleic Acids Res· February 2024

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Synthesis of a Conjugative System from Human Gut Metagenomic Data for Targeted Delivery of Cas9 Antimicrobials.
Thomas A Hamilton, Benjamin R Joris, Arina Shrestha, Tyler S Browne, Sébastien Rodrigue, David R Edgell

ACS Synth Biol· December 2023

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A generalizable Cas9/sgRNA prediction model using machine transfer learning with small high-quality datasets.
Dalton T Ham, Tyler S Browne, Pooja N Banglorewala, Tyler L Wilson, Richard K Michael, David R Edgell

Nat Commun· September 2023

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Noncanonical functions of Ku may underlie essentiality in human cells.
Rachel D Kelly, Gursimran Parmar, Laila Bayat, Matthew E R Maitland, Gilles A Lajoie, David R Edgell

Sci Rep· July 2023

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Telomere-to-telomere genome assembly of .
Daniel J Giguere, Alexander T Bahcheli, Samuel S Slattery, Rushali R Patel, Tyler S Browne, David R Edgell

PeerJ· January 2023

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Metabolically-targeted dCas9 expression in bacteria.
Gregory M Pellegrino, Tyler S Browne, Keerthana Sharath, Khaleda A Bari, Sarah J Vancuren, David R Edgell

Nucleic Acids Res· January 2023

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Superior Conjugative Plasmids Delivered by Bacteria to Diverse Fungi.
Ryan R Cochrane, Arina Shrestha, Mariana M Severo de Almeida, Michelle Agyare-Tabbi, Stephanie L Brumwell, David R Edgell

Biodes Res· August 2022

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Editorial: Genetically mobile elements repurposed by nature and biotechnologists.
Christopher W Lennon, Brian P Callahan, Benoit Cousineau, David R Edgell, Marlene Belfort

Front Mol Biosci· August 2022

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Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics.
Samuel S Slattery, Daniel J Giguere, Emily E Stuckless, Arina Shrestha, Lee-Ann K Briere, David R Edgell

Sci Rep· April 2022

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Conjugation-Based Genome Engineering in .
Stephanie L Brumwell, Katherine D Van Belois, Daniel J Giguere, David R Edgell, Bogumil J Karas

ACS Synth Biol· March 2022

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Cloning of Mitochondrial Genome in and .
Ryan R Cochrane, Stephanie L Brumwell, Arina Shrestha, Daniel J Giguere, Samir Hamadache, David R Edgell

Biology (Basel)· October 2020

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Plasmid-based complementation of large deletions in Phaeodactylum tricornutum biosynthetic genes generated by Cas9 editing.
Samuel S Slattery, Helen Wang, Daniel J Giguere, Csanad Kocsis, Bradley L Urquhart, David R Edgell

Sci Rep· August 2020

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Designer Sinorhizobium meliloti strains and multi-functional vectors enable direct inter-kingdom DNA transfer.
Stephanie L Brumwell, Michael R MacLeod, Tony Huang, Ryan R Cochrane, Rebecca S Meaney, David R Edgell

PLoS One· February 2020

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Modifying a covarying protein-DNA interaction changes substrate preference of a site-specific endonuclease.
Marc Laforet, Thomas A McMurrough, Michael Vu, Christopher M Brown, Kun Zhang, David R Edgell

Nucleic Acids Res· November 2019

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Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing.
Thomas A Hamilton, Gregory M Pellegrino, Jasmine A Therrien, Dalton T Ham, Peter C Bartlett, David R Edgell

Nat Commun· October 2019

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Trans-Kingdom Conjugation within Solid Media from to .
Maximillian P M Soltysiak, Rebecca S Meaney, Samir Hamadache, Preetam Janakirama, David R Edgell

Int J Mol Sci· October 2019

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Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases.
Thomas A McMurrough, Christopher M Brown, Kun Zhang, Georg Hausner, Murray S Junop, David R Edgell

Nucleic Acids Res· December 2018

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mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels.
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell

EMBO Mol Med· September 2018

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Delivery of the Cas9 or TevCas9 system into via conjugation of plasmids from a bacterial donor.
Helen Wang, Samuel S Slattery, Bogumil J Karas, David R Edgell

Bio Protoc· August 2018

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An Expanded Plasmid-Based Genetic Toolbox Enables Cas9 Genome Editing and Stable Maintenance of Synthetic Pathways in Phaeodactylum tricornutum.
Samuel S Slattery, Andrew Diamond, Helen Wang, Jasmine A Therrien, Jeremy T Lant, David R Edgell

ACS Synth Biol· February 2018

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Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.
Julienne C Kaiser, Alyssa N King, Jason C Grigg, Jessica R Sheldon, David R Edgell

PLoS Genet· January 2018

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