Publications by authors named "David R Manning"

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Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia.
Lan Ho Wei, Mohammad Arastoo, Ioanna Georgiou, David R Manning, Natalia A Riobo-Del Galdo

PLoS One· February 2019

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Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G13.
Xueshui Guo, Natalia A Riobo-Del Galdo, Eun Ji Kim, Gregory R Grant, David R Manning

PLoS One· November 2018

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Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K currents in cardiomyocytes and prolongs cardiac action potential duration.
Lan Cheng, Moza Al-Owais, Manuel L Covarrubias, Walter J Koch, David R Manning

J Biol Chem· July 2018

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Evaluating the Activity of Smoothened Toward G Proteins Using [³⁵S]Guanosine 5'-(3-O-thio)triphosphate ([³⁵S]GTPγS).
David R Manning, Feng Shen, Natalia A Riobo

Methods Mol Biol· April 2016

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Smoothened is a fully competent activator of the heterotrimeric G protein G(i).
Feng Shen, Lan Cheng, Andrew E Douglas, Natalia A Riobo, David R Manning

Mol Pharmacol· March 2013

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Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins.
Ariel H Polizio, Pilar Chinchilla, Xiaolen Chen, David R Manning, Natalia A Riobo

Sci Signal· November 2011

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The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened.
Andrew E Douglas, Jennifer A Heim, Feng Shen, Luciana L Almada, Natalia A Riobo, David R Manning

J Biol Chem· September 2011

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Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration.
Ariel H Polizio, Pilar Chinchilla, Xiaole Chen, Sangbumn Kim, David R Manning

J Biol Chem· June 2011

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An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution.
Marykate Crouthamel, Daniel Abankwa, Li Zhang, Cherisse DiLizio, David R Manning

Mol Pharmacol· October 2010

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The Gq and G12 families of heterotrimeric G proteins report functional selectivity.
Li Zhang, Lawrence F Brass, David R Manning

Mol Pharmacol· January 2009

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Pathways of signal transduction employed by vertebrate Hedgehogs.
Natalia A Riobo, David R Manning

Biochem J· May 2007

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Activation of heterotrimeric G proteins by Smoothened.
Natalia A Riobo, Berangere Saucy, Cherisse Dilizio, David R Manning

Proc Natl Acad Sci U S A· August 2006

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The G12 family of G proteins as a reporter of thromboxane A2 receptor activity.
Li Zhang, Cherisse DiLizio, David Kim, Emer M Smyth, David R Manning

Mol Pharmacol· April 2006

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Receptors coupled to heterotrimeric G proteins of the G12 family.
Natalia A Riobo, David R Manning

Trends Pharmacol Sci· March 2005

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Evidence mounts for receptor-independent activation of heterotrimeric G proteins normally in vivo: positioning of the mitotic spindle in C. elegans.
David R Manning

Sci STKE· August 2003

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Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors.
Jing Yang, Jie Wu, Hong Jiang, Richard Mortensen, Sandra Austin, David R Manning

J Biol Chem· November 2002

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Measures of efficacy using G proteins as endpoints: differential engagement of G proteins through single receptors.
David R Manning

Mol Pharmacol· September 2002

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Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist.
Michelle E Page, John F Cryan, Arthur Sullivan, Ashutosh Dalvi, Berangere Saucy, David R Manning

J Pharmacol Exp Ther· September 2002

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Analysis of G protein activation in Sf9 and mammalian cells by agonist-promoted [35S]GTP gamma S binding.
Rolf T Windh, David R Manning

Methods Enzymol· June 2002

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Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors.
Sandra Siehler, David R Manning

Biochim Biophys Acta· May 2002

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Expression of G protein-coupled receptors and G proteins in Sf9 cells: analysis of coupling by radioligand binding.
Rolf T Windh, David R Manning

Methods Enzymol· February 2002

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