Publications by authors named "David Rampe"

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Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K channel.
Roy J Vaz, Jiesheng Kang, Yongyi Luo, David Rampe

Bioorg Med Chem Lett· February 2018

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Observations on conducting whole-cell patch clamping of the hERG cardiac K channel in pure human serum.
Jiesheng Kang, Yongyi Luo, Michelle Searles, David Rampe

J Appl Toxicol· April 2017

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Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic.
Jiesheng Kang, David R Compton, Roy J Vaz, David Rampe

Naunyn Schmiedebergs Arch Pharmacol· October 2016

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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.
Bernard Fermini, Jules C Hancox, Najah Abi-Gerges, Matthew Bridgland-Taylor, Khuram W Chaudhary, David Rampe

J Biomol Screen· January 2016

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On Becoming a Pharmacologist: Channeling David Triggle.
David Rampe, Murali Gopalakrishnan

Biochem Pharmacol· November 2015

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A Festschrift in honor of David J. Triggle.
Murali Gopalakrishnan, David Rampe, Christopher Triggle

Biochem Pharmacol· November 2015

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L-type Ca2+ channel responses to bay k 8644 in stem cell-derived cardiomyocytes are unusually dependent on holding potential and charge carrier.
Junzhi Ji, Jiesheng Kang, David Rampe

Assay Drug Dev Technol· August 2014

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A history of the role of the hERG channel in cardiac risk assessment.
David Rampe, Arthur M Brown

J Pharmacol Toxicol Methods· February 2014

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Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes.
Jiesheng Kang, Xiao-Liang Chen, Junzhi Ji, Qiubo Lei, David Rampe

J Pharmacol Exp Ther· May 2012

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Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat.
Harry Meng, James Cao, Jiesheng Kang, Xiaoyou Ying, Junzhi Ji, David Rampe

Toxicol Lett· January 2012

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Oversulfated chondroitin sulfate and OSCS-contaminated heparin cause dose- and route-dependent hemodynamic effects in the rat.
Alain Corbier, Nathalie Le Berre, David Rampe, Harry Meng, Martin Lorenz

Toxicol Sci· June 2011

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Manual whole-cell patch-clamping of the HERG cardiac K+ channel.
Xiao-Liang Chen, Jiesheng Kang, David Rampe

Methods Mol Biol· February 2011

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In vitro electrocardiographic and cardiac ion channel effects of (-)-epigallocatechin-3-gallate, the main catechin of green tea.
Jiesheng Kang, Hsien Cheng, Junzhi Ji, Josephine Incardona, David Rampe

J Pharmacol Exp Ther· August 2010

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In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative.
Craig Smith, Sathapana Kongsamut, Hongge Wang, Junzhi Ji, Jiesheng Kang, David Rampe

Clin Exp Pharmacol Physiol· November 2009

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Functional interaction between DPI 201-106, a drug that mimics congenital long QT syndrome, and sevoflurane on the guinea-pig cardiac action potential.
Jiesheng Kang, Xiao-Liang Chen, William P Reynolds, David Rampe

Clin Exp Pharmacol Physiol· December 2007

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ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.
Laurie A Hanson, Alan S Bass, Gary Gintant, Scott Mittelstadt, David Rampe

J Pharmacol Toxicol Methods· October 2006

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Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs.
Jiesheng Kang, William P Reynolds, Xiao-Liang Chen, Junzhi Ji, Hongge Wang, David E Rampe

Anesthesiology· May 2006

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Human ether-a-go-go related gene (HERG): a chemist's perspective.
Roy J Vaz, Yi Li, David Rampe

Prog Med Chem· November 2005

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Predictive models for hERG potassium channel blockers.
Giovanni Cianchetta, Yi Li, Jiesheng Kang, David Rampe, Arnaldo Fravolini

Bioorg Med Chem Lett· August 2005

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Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel.
Jiesheng Kang, Xiao-Liang Chen, Hongge Wang, Junzhi Ji, Hsien Cheng, David Rampe

Mol Pharmacol· March 2005

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Pentamidine-induced long QT syndrome and block of hERG trafficking.
Yuri A Kuryshev, Eckhard Ficker, Lu Wang, Peter Hawryluk, Adrienne T Dennis, David Rampe

J Pharmacol Exp Ther· January 2005

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Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.
Gregory H Merriman, Liang Ma, Patrick Shum, Daniel McGarry, Frank Volz, David Rampe

Bioorg Med Chem Lett· January 2005

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Cardiac ion channel effects of tolterodine.
Jiesheng Kang, Xiao-Liang Chen, Hongge Wang, Junzhi Ji, William Reynolds, David Rampe

J Pharmacol Exp Ther· March 2004

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P2X7 receptor modulation of beta-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia.
David Rampe, Lin Wang, Garth E Ringheim

J Neuroimmunol· February 2004

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Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
Robert Pearlstein, Roy Vaz, David Rampe

J Med Chem· May 2003

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