Publications by authors named "David Root"

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Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis.
Jeffrey C Hsiao, Douglas M Warui, Jason J Kwon, Margaret B Dreishpoon, Nolan R Bick, David E Root

Nat Commun· December 2025

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Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets.
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, David E Root

Cancer Discov· September 2025

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VGluT3 BNST neurons transmit GABA and restrict sucrose consumption.
Annie Ly, Rachel Karnosky, Emily D Prévost, Hayden Hotchkiss, Julianne M Pelletier, David H Root

Mol Metab· August 2025

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Morphological map of under- and overexpression of genes in human cells.
Srinivas Niranj Chandrasekaran, Eric Alix, John Arevalo, Adriana Borowa, Patrick J Byrne, David E Root

Nat Methods· August 2025

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Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes.
Dillon J McGovern, Alysabeth Phillips, Annie Ly, Emily D Prévost, Lucy Ward, David H Root

J Neurosci· July 2025

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Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents.
Constanze Schneider, Gabriela Alexe, Lucy A Merickel, Ashleigh Meyer, Michelle L Swift, David E Root

bioRxiv· July 2025

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Indirect, but not direct, lateral habenula projections to ventral tegmental area regulate the long-term consequences of neuropathic pain.
Emily D Prévost, David H Root

Neuropsychopharmacology· June 2025

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Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia.
Stefan Bjelosevic, Rahel Fauth, Brian T Do, Gabriela Alexe, Lucy A Merickel, David E Root

bioRxiv· June 2025

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Red Light Sensitivity of Non-image and Image Forming Visual Systems of Laboratory Rodents: Circadian Disruption and Behavioral Detection.
William J Stritzel, Catherine Levy, James Russell Ravenel, Helen K Strnad, Marwa Osman, David H Root

J Neurosci· May 2025

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Editorial Expression of Concern: A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.
Cory M Johannessen, Laura A Johnson, Federica Piccioni, Aisha Townes, Dennie T Frederick, David E Root

Nature· May 2025

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Assessing the role of BNST GABA neurons in backward conditioned suppression.
Annie Ly, Hayden Hotchkiss, Emily D Prévost, Julianne M Pelletier, Melissa A Deming, David H Root

Neurobiol Learn Mem· May 2025

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A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction.
Kannan V Manian, Connor H Ludwig, Yan Zhao, Nathan Abell, Xiaoping Yang, David E Root

bioRxiv· March 2025

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missense mutants disrupt SWI/SNF complex stability and remodeling activity.
Garrett W Cooper, Benjamin P Lee, Won Jun Kim, Yongdong Su, Victor Z Chen, David E Root

Res Sq· March 2025

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Untangling dopamine and glutamate in the ventral tegmental area.
Emily D Prévost, Lucy A Ward, Daniel Alas, Giulia Aimale, Sara Ikenberry, David H Root

bioRxiv· February 2025

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VGluT3 BNST neurons transmit GABA and restrict feeding without affecting rewarding or aversive processing.
Annie Ly, Rachel Karnosky, Emily D Prévost, Hayden Hotchkiss, Julianne Pelletier, David H Root

bioRxiv· January 2025

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Assessing the role of BNST GABA neurons in backward conditioned suppression.
Annie Ly, Hayden Hotchkiss, Emily D Prévost, Julianne Pelletier, Melissa Deming, David H Root

bioRxiv· January 2025

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VPS18 contributes to phagosome membrane integrity in -infected macrophages.
Charul Jani, Neha Jain, Amanda K Marsh, Pooja Uchil, Triet Doan, David E Root

Sci Adv· January 2025

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Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors.
Daniel J Merk, Foteini Tsiami, Sophie Hirsch, Bianca Walter, Lara A Haeusser, David E Root

Genome Biol· December 2024

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Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons.
Emily D Prévost, Alysabeth Phillips, Kristoffer Lauridsen, Gunnar Enserro, Bodhi Rubinstein, David H Root

J Neurosci· November 2024

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Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer.
Alissandra L Hillis, Timothy D Martin, Haley E Manchester, Jenny Högström, Na Zhang, David E Root

Cancer Res· October 2024

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Total loss of gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity.
Muhannad Abu-Remaileh, Nicole S Persky, Yenarae Lee, David E Root, William G Kaelin

Proc Natl Acad Sci U S A· October 2024

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Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Jason J Kwon, Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, David E Root

bioRxiv· October 2024

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Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma.
Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, David E Root

Acta Neuropathol Commun· August 2024

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Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, David Root

bioRxiv· July 2024

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Salience signaling and stimulus scaling of ventral tegmental area glutamate neuron subtypes.
Dillon J McGovern, Alysabeth Phillips, Annie Ly, Emily D Prévost, Lucy Ward, David H Root

bioRxiv· June 2024

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