Publications by authors named "David Sebag-Montefiore"

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AI-powered immune profiling from histopathology slides for chemo-radiotherapy outcome prediction in rectal cancer: a study using clinical trial and real-world cohorts.
Zhuoyan Shen, Douglas Brand, Mikaël Simard, Adam P Levine, Sumeet Hindocha, David Sebag-Montefiore

EBioMedicine· December 2025

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Personalising anal cancer radiotherapy dose (PLATO): protocol for a multicentre integrated platform trial.
Russell Frood, Alexandra Gilbert, Duncan Gilbert, Natalie L Abbott, Susan D Richman, David Sebag-Montefiore

BMJ Open· November 2025

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Predicting acute diarrhoea in rectal cancer chemoradiotherapy: Secondary analysis of the phase III ARISTOTLE trial.
Ying Zhang, Douglas Brand, Zhuoyan Shen, Mikael Simard, Sumeet Hindocha, David Sebag-Montefiore

Radiother Oncol· September 2025

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Tumour-Infiltrating Lymphocytes, Tumour Cell Density, and Response to Neoadjuvant Short-Course Radiotherapy in Rectal Cancer: A Translational Sub-Study from the MRC CR07 Clinical Trial.
Jonathan P Callaghan, Ross Jarrett, Alice C Westwood, Jon Laye, Philip Quirke, David Sebag-Montefiore

Cancers (Basel)· September 2025

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Standard versus reduced-dose chemoradiotherapy in anal cancer (PLATO-ACT4): short-term results of a phase 2 randomised controlled trial.
Alexandra Gilbert, Richard Adams, Joanne Webster, Duncan C Gilbert, Natalie L Abbott, David Sebag-Montefiore

Lancet Oncol· June 2025

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International consensus to define outcomes for trials of chemoradiotherapy for anal cancer (CORMAC-2): defining the outcomes from the CORMAC core outcome set.
Robert Samuel, Stephen R Knight, Richard Adams, Prajnan Das, Jennifer Dorth, David Sebag-Montefiore

EClinicalMedicine· December 2024

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Pre-treatment magnetic resonance imaging in anal cancer: large-scale evaluation of mrT, mrN and novel staging parameters.
Hema Sekhar, Rohit Kochhar, Bernadette Carrington, Thomas Kaye, Damian Tolan, David Sebag-Montefiore

Br J Cancer· October 2024

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Standard or high dose chemoradiotherapy, with or without the protease inhibitor nelfinavir, in patients with locally advanced pancreatic cancer: The phase 1/randomised phase 2 SCALOP-2 trial.
Somnath Mukherjee, Cathy Qi, Rachel Shaw, Christopher M Jones, John A Bridgewater, David Sebag-Montefiore

Eur J Cancer· September 2024

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The use of master protocols for efficient trial design to evaluate radiotherapy interventions: a systematic review.
Alexandra Gilbert, Robert Samuel, Daniel Cagney, David Sebag-Montefiore, Julia Brown

J Natl Cancer Inst· August 2024

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Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors.
Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore

EBioMedicine· August 2024

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Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures.
Umair Mahmood, Andrew Blake, Sanjay Rathee, Leslie Samuel, Graeme Murray, David Sebag-Montefiore

Cancer Res Commun· July 2024

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Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy.
Maxime W Lafarge, Enric Domingo, Korsuk Sirinukunwattana, Ruby Wood, Leslie Samuel, David Sebag-Montefiore

NPJ Precis Oncol· April 2024

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Brain Re-Irradiation Or Chemotherapy: a phase II randomised trial of re-irradiation and chemotherapy in patients with recurrent glioblastoma (BRIOChe) - protocol for a multi-centre open-label randomised trial.
Eleanor M Hudson, Samantha Noutch, Joanne Webster, Sarah R Brown, Florien W Boele, David Sebag-Montefiore

BMJ Open· March 2024

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Patient-reported outcomes in PROSPECT trial (Alliance N1048) - FOLFOX is not a panacea.
Sean M O'Cathail, Richard Adams, Maria A Hawkins, David Sebag-Montefiore, Corrie A M Marijnen

Clin Transl Radiat Oncol· November 2023

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Preoperative Treatment of Locally Advanced Rectal Cancer.
David Sebag-Montefiore, Andres Cervantes, Claus Rodel

N Engl J Med· October 2023

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Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision.
Alexandra Gilbert, Victoria Homer, Kristian Brock, Stephan Korsgen, Ian Geh, David Sebag-Montefiore

Lancet Healthy Longev· December 2022

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"Global Multidisciplinary Team Meetings": Challenging Cases Virtual Forums from the International Multidisciplinary Anal Cancer Conference (IMACC).
Eva Segelov, Marianne Grønlie Guren, David Sebag-Montefiore, Sheela Rao, Anders Johnsson

Clin Colorectal Cancer· September 2022

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Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units.
Sharon B Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, David Sebag-Montefiore

Trials· September 2022

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Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study.
Stelios Theophanous, Per-Ivar Lønne, Ananya Choudhury, Maaike Berbee, Andre Dekker, David Sebag-Montefiore

Diagn Progn Res· August 2022

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Prognostic factors for patients with anal cancer treated with conformal radiotherapy-a systematic review.
Stelios Theophanous, Robert Samuel, John Lilley, Ann Henry, David Sebag-Montefiore

BMC Cancer· June 2022

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Bayesian network structure for predicting local tumor recurrence in rectal cancer patients treated with neoadjuvant chemoradiation followed by surgery.
Biche Osong, Carlotta Masciocchi, Andrea Damiani, Inigo Bermejo, Elisa Meldolesi, David Sebag-Montefiore

Phys Imaging Radiat Oncol· April 2022

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A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer (APHRODITE): protocol for a multicentre, open-label randomised controlled trial.
Eleanor M Hudson, Samantha Noutch, Sarah Brown, Ravi Adapala, Simon P Bach, David Sebag-Montefiore

BMJ Open· April 2022

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A Machine-Learning-Based Bibliometric Analysis of the Scientific Literature on Anal Cancer.
Pierfrancesco Franco, Eva Segelov, Anders Johnsson, Rachel Riechelmann, Marianne G Guren, David Sebag-Montefiore

Cancers (Basel)· March 2022

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Treatment of Squamous Cell Carcinoma of the Anus, Unresolved Areas and Future Perspectives for Research: Perspectives of Research Needs in Anal Cancer.
Marianne Grønlie Guren, David Sebag-Montefiore, Pierfrancesco Franco, Anders Johnsson, Eva Segelov

Clin Colorectal Cancer· December 2021

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The benefit of MR-only radiotherapy treatment planning for anal and rectal cancers: A planning study.
David Bird, Michael G Nix, Hazel McCallum, Mark Teo, Alexandra Gilbert, David Sebag-Montefiore

J Appl Clin Med Phys· November 2021

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