Publications by authors named "David Timson"

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Triosephosphate isomerase from Fasciola hepatica: high-resolution crystal structure as a drug target.
Georgios Kontellas, David J Studholme, Mark van der Giezen, David J Timson, Jennifer A Littlechild

Acta Crystallogr F Struct Biol Commun· September 2025

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Galactose epimerase deficiency: lessons from the GalNet registry.
Britt Derks, Didem Demirbas, Rodrigo R Arantes, Samantha Banford, Alberto B Burlina, David J Timson

Orphanet J Rare Dis· September 2022

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L-Asparaginase from Produced by a Recombinant Strain.
Marcela Freitas, Paula Souza, Mauricio Homem-de-Mello, Yris M Fonseca-Bazzo, Damaris Silveira, David Timson

Pharmaceuticals (Basel)· June 2022

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Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1.
Eduardo Salido, David J Timson, Isabel Betancor-Fernández, Rogelio Palomino-Morales, Ernesto Anoz-Carbonell

J Pers Med· May 2022

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Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil.
Shamsudeen Umar Dandare, Maria Håkansson, L Anders Svensson, David J Timson, Christopher C R Allen

Acta Crystallogr F Struct Biol Commun· April 2022

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[C]-galactose breath test in a patient with galactokinase deficiency and spastic diparesis.
Can Ficicioglu, Didem Demirbas, Britt Derks, G Shashidhar Pai, David J Timson

JIMD Rep· May 2021

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The structural and molecular biology of type IV galactosemia.
Samantha Banford, David J Timson

Biochimie· April 2021

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Praziquantel: An Enigmatic, Yet Effective, Drug.
David J Timson

Methods Mol Biol· March 2021

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Galactosemia: Towards Pharmacological Chaperones.
Samantha Banford, Thomas J McCorvie, Angel L Pey, David J Timson

J Pers Med· February 2021

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Galactokinase deficiency: lessons from the GalNet registry.
M Estela Rubio-Gozalbo, Britt Derks, Anibh Martin Das, Uta Meyer, Dorothea Möslinger, David J Timson

Genet Med· January 2021

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Destressing Yeast for Higher Biofuel Yields: Can Excess Chaotropicity Be Mitigated?
David J Timson, Joshua Eardley

Appl Biochem Biotechnol· December 2020

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RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development.
Paul McCusker, Wasim Hussain, Paul McVeigh, Erin McCammick, Nathan G Clarke, David J Timson

Int J Parasitol Drugs Drug Resist· December 2020

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analysis of the effects of disease-associated mutations of β-hexosaminidase A in Tay-Sachs disease.
Mohammad Ihsan Fazal, Rafal Kacprzyk, David J Timson

J Genet· October 2020

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The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity.
Ernesto Anoz-Carbonell, David J Timson, Angel L Pey, Milagros Medina

Antioxidants (Basel)· August 2020

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Pilot Evaluation of Two Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics.
Clare F Collett, Russell M Morphew, David Timson, Helen C Phillips, Peter M Brophy

Molecules· July 2020

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The roles and applications of chaotropes and kosmotropes in industrial fermentation processes.
David J Timson

World J Microbiol Biotechnol· June 2020

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Therapies for galactosemia: a patent landscape.
David J Timson

Pharm Pat Anal· May 2020

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The Schistosoma mansoni tegumental allergen protein, SmTAL1: Binding to an IQ-motif from a voltage-gated ion channel and effects of praziquantel.
Charlotte M Thomas, David J Timson

Cell Calcium· March 2020

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Analysis of the Effects of Point Mutations on α-Globin: Implications for α-Thalassemia.
Agathe Horri-Naceur, David J Timson

Hemoglobin· March 2020

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Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity.
Florencia Ferraro, Ileana Corvo, Lucia Bergalli, Andrea Ilarraz, Mauricio Cabrera, David J Timson

Sci Rep· February 2020

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Dynamic origins of substrate promiscuity in bacterial galactokinases.
Margaret McAuley, Meilan Huang, David J Timson

Carbohydr Res· December 2019

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Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1).
Clare F Megarity, Hoda Abdel-Aal Bettley, M Clare Caraher, Katherine A Scott, Roger C Whitehead, David J Timson

Chembiochem· November 2019

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Evidence for chaotropicity/kosmotropicity offset in a yeast growth model.
Joshua Eardley, Cinzia Dedi, Marcus Dymond, John E Hallsworth, David J Timson

Biotechnol Lett· November 2019

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A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer.
Pavla Vankova, Eduardo Salido, David J Timson, Petr Man, Angel L Pey

Biomolecules· November 2019

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Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity.
Clare F Megarity, David J Timson

Biosci Rep· September 2019

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