Publications by authors named "David W End"

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Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series.
Patrick Angibaud, Laurence Mevellec, Christophe Meyer, Xavier Bourdrez, Patricia Lezouret, David W End

Eur J Med Chem· May 2007

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Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets.
Ruisheng Yao, Yian Wang, Yan Lu, William J Lemon, David W End

Carcinogenesis· July 2006

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Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations.
Ronald A Lubet, Konstantin Christov, Ming You, Ruisheng Yao, Vernon E Steele, David W End

Mol Cancer Ther· April 2006

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Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I.
Ashis K Saha, David W End

Bioorg Med Chem Lett· March 2005

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4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.
Patrick Angibaud, Ashis K Saha, Xavier Bourdrez, David W End, Eddy Freyne

Bioorg Med Chem Lett· December 2003

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Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
Patrick Angibaud, Xavier Bourdrez, David W End, Eddy Freyne, Michel Janicot

Bioorg Med Chem Lett· December 2003

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5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.
Patrick Angibaud, Xavier Bourdrez, Ann Devine, David W End, Eddy Freyne

Bioorg Med Chem Lett· May 2003

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Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.
William T Gunning, Paula M Kramer, Ronald A Lubet, Vernon E Steele, David W End

Clin Cancer Res· May 2003

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