Publications by authors named "David Wesche"

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The use of quantitative clinical pharmacology approaches to support moxidectin dosing recommendations in lactation.
Nolan D Wood, Danelle Smith, Sally A Kinrade, Mark T Sullivan, Craig R Rayner, David Wesche

PLoS Negl Trop Dis· August 2024

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Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.
Ayumi E Pottenger, Debashish Roy, Selvi Srinivasan, Thomas E J Chavas, Vladmir Vlaskin, David Wesche

Sci Adv· April 2024

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Development and application of a PBPK modeling strategy to support antimalarial drug development.
Nada Abla, Eleanor Howgate, Karen Rowland-Yeo, Maurice Dickins, Mackenzie C Bergagnini-Kolev, David Wesche

CPT Pharmacometrics Syst Pharmacol· September 2023

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Characterizing the Blood-Stage Antimalarial Activity of Tafenoquine in Healthy Volunteers Experimentally Infected With Plasmodium falciparum.
Bridget E Barber, Azrin N Abd-Rahman, Rebecca Webster, Adam J Potter, Stacey Llewellyn, David Wesche

Clin Infect Dis· June 2023

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PBPK modeling of ivermectin-Considerations for the purpose of developing alternative routes to optimize its safety profile.
Karen Rowland Yeo, David Wesche

CPT Pharmacometrics Syst Pharmacol· May 2023

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R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini.
Christine Falcoz, Serge Guzy, Jana Kovač, Isabel Meister, Jean Coulibaly, David Wesche

J Pharmacokinet Pharmacodyn· June 2022

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Correction to: R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini.
Christine Falcoz, Serge Guzy, Jana Kovač, Isabel Meister, Jean Coulibaly, David Wesche

J Pharmacokinet Pharmacodyn· June 2022

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Model-informed drug repurposing: A pharmacometric approach to novel pathogen preparedness, response and retrospection.
Michael Dodds, Yuan Xiong, Samer Mouksassi, Carl M Kirkpatrick, Katrina Hui, David Wesche

Br J Clin Pharmacol· September 2021

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Model-Informed Drug Development for Anti-Infectives: State of the Art and Future.
Craig R Rayner, Patrick F Smith, David Andes, Kayla Andrews, Hartmut Derendorf, David Wesche

Clin Pharmacol Ther· April 2021

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Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development.
Kayla Ann Andrews, Joel S Owen, James McCarthy, David Wesche, Nathalie Gobeau

Clin Transl Sci· March 2021

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Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure.
Selvi Srinivasan, Debashish Roy, Thomas E J Chavas, Vladimir Vlaskin, Duy-Khiet Ho, David Wesche

J Control Release· March 2021

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Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection.
Melanie R Nicol, Abhay Joshi, Matthew L Rizk, Philip E Sabato, Radojka M Savic, David Wesche

Clin Pharmacol Ther· December 2020

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Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling.
Karen Rowland Yeo, Mian Zhang, Xian Pan, Alice Ban Ke, Hannah M Jones, David Wesche

Clin Pharmacol Ther· November 2020

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Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19.
Craig R Rayner, Louis Dron, Jay J H Park, Eric H Decloedt, Mark F Cotton, David Wesche

Am J Trop Med Hyg· October 2020

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Optimizing COVID-19 Candidate Therapeutics: Thinking Without Borders.
Craig R Rayner, Patrick F Smith, Kevin Hershberger, David Wesche

Clin Transl Sci· September 2020

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Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus disease (COVID-19): a structured summary of a study protocol for a randomised controlled trial.
Ruanne V Barnabas, Elizabeth Brown, Anna Bershteyn, R Scott Miller, Mark Wener, David Wesche

Trials· June 2020

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Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data.
Xin Hui S Chan, Yan Naung Win, Ilsa L Haeusler, Jireh Y Tan, Shanghavie Loganathan, David Wesche

PLoS Med· March 2020

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Model-Informed Assessment of Anti-Infectives for Young Children in Low- and Middle-Income Countries.
Ping Zhao, Jonathan Arm, Lyou-Fu Ma, Stephen Ward, David Hermann, David Wesche

CPT Pharmacometrics Syst Pharmacol· April 2019

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Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria.
J Kevin Baird, Melva Louisa, Rintis Noviyanti, Lenny Ekawati, Iqbal Elyazar, David Wesche

JAMA Netw Open· August 2018

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Model-Informed Drug Development for Malaria Therapeutics.
Kayla Ann Andrews, David Wesche, James McCarthy, Jörg J Möhrle, Joel Tarning

Annu Rev Pharmacol Toxicol· January 2018

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Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy.
Dwain Tolbert, James Cloyd, Victor Biton, Ihor Bekersky, Mark Walzer, David Wesche

Epilepsia· June 2015

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Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax.
Brice Campo, Omar Vandal, David L Wesche, Jeremy N Burrows

Pathog Glob Health· May 2015

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Population dose-response analysis of daily seizure count following vigabatrin therapy in adult and pediatric patients with refractory complex partial seizures.
Jace C Nielsen, Matthew M Hutmacher, David L Wesche, Dwain Tolbert, Mahlaqa Patel

J Clin Pharmacol· January 2015

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Vigabatrin pediatric dosing information for refractory complex partial seizures: results from a population dose-response analysis.
Jace C Nielsen, Dwain Tolbert, Mahlaqa Patel, Kenneth G Kowalski, David L Wesche

Epilepsia· December 2014

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Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms.
Jace C Nielsen, Kenneth G Kowalski, Aziz Karim, Mahlaqa Patel, David L Wesche

Clin Pharmacokinet· November 2014

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