Publications by authors named "David Winpenny"

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Development of Purine and Pyrrolopyrimidine Scaffolds as Potent, Selective, and Brain Penetrant NUAK1 Inhibitors.
Gregory G Aldred, Helen K Boffey, Henriette M G Willems, David Winpenny, Helen Scott

ACS Med Chem Lett· November 2025

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Development of the Pyrido[2,3-]pyrimidin-7(8)-one Scaffold toward Potent and Selective NUAK1 Inhibitors.
Timothy P C Rooney, Gregory G Aldred, David Winpenny, Helen Scott, Henriette M G Willems

ACS Med Chem Lett· February 2025

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The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K).
Gregory G Aldred, Timothy P C Rooney, Henriette M G Willems, Helen K Boffey, Christopher Green, David Winpenny

RSC Med Chem· October 2023

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Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.
Henriëtte M G Willems, Simon Edwards, Helen K Boffey, Stephen J Chawner, Christopher Green, David Winpenny

RSC Med Chem· May 2023

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The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, David Winpenny

J Med Chem· January 2023

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Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Helen K Boffey, Timothy P C Rooney, Henriette M G Willems, Simon Edwards, Christopher Green, David Winpenny

J Med Chem· February 2022

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Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists.
David Winpenny, Mellissa Clark, Darren Cawkill

Br J Pharmacol· April 2016

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Staphylococcus aureus haem biosynthesis: characterisation of the enzymes involved in final steps of the pathway.
Susana A L Lobo, Alan Scott, Marco A M Videira, David Winpenny, Mark Gardner

Mol Microbiol· August 2015

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The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist.
Jennifer C Gardiner, Anthony J Kirkup, John Curry, Sian Humphreys, Paul O'Regan, David Winpenny

Eur J Pharmacol· October 2014

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Use of libraries to access new chemical space: applications to CRTH2.
M Abid Masood, Mark Gardner, Kevin Dack, David Winpenny, Graham Lunn

Bioorg Med Chem Lett· June 2012

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