Publications by authors named "Dawn Yates"

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A workflow to practically apply true dose considerations to in vitro testing for next generation risk assessment.
Beate Nicol, Evita Vandenbossche-Goddard, Charlotte Thorpe, Richard Newman, Hiral Patel, Dawn Yates

Toxicology· June 2024

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Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.
Amanda Van de Poël, Leticia Toledo-Sherman, Perla Breccia, Roger Cachope, Jennifer R Bate, Dawn Yates

J Med Chem· April 2021

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Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease.
Andrew J Stott, Michel C Maillard, Vahri Beaumont, David Allcock, Omar Aziz, Dawn Yates

ACS Med Chem Lett· March 2021

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Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
Leticia Toledo-Sherman, Perla Breccia, Roger Cachope, Jennifer R Bate, Ivan Angulo-Herrera, Dawn Yates

J Med Chem· March 2019

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Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Christopher A Luckhurst, Omar Aziz, Vahri Beaumont, Roland W Bürli, Perla Breccia, Dawn Yates

Bioorg Med Chem Lett· January 2019

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Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
Christopher A Luckhurst, Perla Breccia, Andrew J Stott, Omar Aziz, Helen L Birch, Dawn Yates

ACS Med Chem Lett· January 2016

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Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
John Wityak, Kevin F McGee, Michael P Conlon, Ren Hua Song, Bryan C Duffy, Dawn Yates

J Med Chem· April 2015

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Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease.
Leticia M Toledo-Sherman, Michael E Prime, Ladislav Mrzljak, Maria G Beconi, Alan Beresford, Dawn Yates

J Med Chem· February 2015

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Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
Petr Vodicka, Junghyun Lim, Dana T Williams, Kimberly B Kegel, Kathryn Chase, Dawn Yates

J Huntingtons Dis· September 2014

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Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
Roland W Bürli, Christopher A Luckhurst, Omar Aziz, Kim L Matthews, Dawn Yates

J Med Chem· December 2013

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Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.
Maria Beconi, Omar Aziz, Kim Matthews, Lara Moumné, Catherine O'Connell, Dawn Yates

PLoS One· January 2013

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Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048.
Maria G Beconi, Dawn Yates, Kathryn Lyons, Kim Matthews, Steve Clifton

Drug Metab Dispos· December 2012

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