Publications by authors named "Dean A Wacker"

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Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.
Susheel J Nara, Srinivas Jogi, Srinivas Cheruku, Sarkunam Kandhasamy, Firoz Jaipuri, Dean A Wacker

J Med Chem· July 2022

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Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.
Joseph Carpenter, Gang Wu, Ying Wang, Erica M Cook, Tao Wang, Dean A Wacker

ACS Med Chem Lett· September 2021

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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT Receptor Agonists.
Joseph Carpenter, Ying Wang, Gang Wu, Jianxin Feng, Xiang-Yang Ye, Dean A Wacker

J Med Chem· July 2017

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Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119.
Dean A Wacker, Ying Wang, Matthias Broekema, Karen Rossi, Steven O'Connor

J Med Chem· September 2014

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Synthesis and structure-activity relationship of dihydrobenzofuran derivatives as novel human GPR119 agonists.
Xiang-Yang Ye, Christian L Morales, Ying Wang, Karen A Rossi, Sarah E Malmstrom, Dean A Wacker

Bioorg Med Chem Lett· June 2014

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Discovery and development of 5-HT(₂C) receptor agonists for obesity: is there light at the end of the tunnel?
Keith J Miller, Dean A Wacker

Future Med Chem· December 2010

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Position 5.46 of the serotonin 5-HT2A receptor contributes to a species-dependent variation for the 5-HT2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation.
Keith J Miller, Ginger Y Wu, Jeffrey G Varnes, Paul Levesque, Julia Li, Dean A Wacker

Mol Pharmacol· December 2009

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Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases.
Dean A Wacker, Keith J Miller

Curr Opin Drug Discov Devel· July 2008

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Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors.
Jeffrey G Varnes, Dean A Wacker, Donald J P Pinto, Michael J Orwat, Jay P Theroff

Bioorg Med Chem Lett· January 2008

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From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.
Joseph B Santella, Daniel S Gardner, Wenqing Yao, Chongsheng Shi, Prabhakar Reddy, Dean A Wacker

Bioorg Med Chem Lett· January 2008

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Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors.
Jeffrey G Varnes, Dean A Wacker, Irina C Jacobson, Mimi L Quan, Christopher D Ellis

Bioorg Med Chem Lett· December 2007

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CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
James R Pruitt, Douglas G Batt, Dean A Wacker, Lori L Bostrom, Shon K Booker

Bioorg Med Chem Lett· June 2007

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Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
Dean A Wacker, Jeffrey G Varnes, Sarah E Malmstrom, Xueying Cao, Chen-Pin Hung

J Med Chem· March 2007

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Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
George V De Lucca, Ui Tae Kim, Brian J Vargo, John V Duncia, Joseph B Santella, Dean A Wacker

J Med Chem· March 2005

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N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists.
Douglas G Batt, Gregory C Houghton, John Roderick, Joseph B Santella, Dean A Wacker

Bioorg Med Chem Lett· February 2005

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Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.
Jeffrey G Varnes, Daniel S Gardner, Joseph B Santella, John V Duncia, Melissa Estrella, Dean A Wacker

Bioorg Med Chem Lett· April 2004

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Solid-phase synthesis of alkyl aryl ethers via the Ullmann condensation.
Xiao-Yi Xiao, Rongshi Li, David Hurst, Hui Zhuang, Shuhao Shi, Dean A Wacker

J Comb Chem· October 2002

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CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Dean A Wacker, Joseph B Santella, Daniel S Gardner, Jeffrey G Varnes, Melissa Estrella

Bioorg Med Chem Lett· July 2002

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