Publications by authors named "Dean Bok"

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Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas.
Kun Do Rhee, Yanjie Wang, Johanna Ten Hoeve, Linsey Stiles, Thao Thi Thu Nguyen, Dean Bok

Nat Commun· November 2022

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Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes.
Jane Hu, Gayle J Pauer, Stephanie A Hagstrom, Dean Bok, Meghan J DeBenedictis

Redox Biol· October 2020

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Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport.
Ming Zhong, Riki Kawaguchi, Brianna Costabile, Yuyan Tang, Jane Hu, Dean Bok

Proc Natl Acad Sci U S A· May 2020

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Genetic analyses of human fetal retinal pigment epithelium gene expression suggest ocular disease mechanisms.
Boxiang Liu, Melissa A Calton, Nathan S Abell, Gillie Benchorin, Michael J Gloudemans, Dean Bok

Commun Biol· April 2020

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Downregulation of splicing regulator RBFOX1 compromises visual depth perception.
Lei Gu, Dean Bok, Fei Yu, Joseph Caprioli, Natik Piri

PLoS One· January 2019

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Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration.
Tamara L Lenis, Jane Hu, Sze Yin Ng, Zhichun Jiang, Shanta Sarfare, Dean Bok

Proc Natl Acad Sci U S A· November 2018

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Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium.
Jeremy D Cook, Sze Yin Ng, Marcia Lloyd, Shannan Eddington, Hui Sun, Dean Bok

J Biol Chem· December 2017

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Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.
Tamara L Lenis, Shanta Sarfare, Zhichun Jiang, Marcia B Lloyd, Dean Bok

Proc Natl Acad Sci U S A· April 2017

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Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.
Minghao Jin, Songhua Li, Jane Hu, Heather H Jin, Samuel G Jacobson, Dean Bok

Adv Exp Med Biol· April 2016

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Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium.
Joanna J Kaylor, Roxana A Radu, Nicholas Bischoff, Jacob Makshanoff, Jane Hu, Dean Bok

PLoS One· February 2016

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Temperature-sensitive retinoid isomerase activity of RPE65 mutants associated with Leber Congenital Amaurosis.
Songhua Li, Jane Hu, Robin J Jin, Ashok Aiyar, Samuel G Jacobson, Dean Bok

J Biochem· August 2015

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Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration.
Monte J Radeke, Carolyn M Radeke, Ying-Hsuan Shih, Jane Hu, Dean Bok

Genome Med· July 2015

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The use of cultured human fetal retinal pigment epithelium in studies of the classical retinoid visual cycle and retinoid-based disease processes.
Jane Hu, Dean Bok

Exp Eye Res· September 2014

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Rescue of enzymatic function for disease-associated RPE65 proteins containing various missense mutations in non-active sites.
Songhua Li, Tadahide Izumi, Jane Hu, Heather H Jin, Ahmed-Abdul A Siddiqui, Dean Bok

J Biol Chem· July 2014

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Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.
Roxana A Radu, Jane Hu, Zhichun Jiang, Dean Bok

J Biol Chem· March 2014

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Understanding RPE lipofuscin.
Janet R Sparrow, John E Dowling, Dean Bok

Invest Ophthalmol Vis Sci· December 2013

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CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells.
Kun Do Rhee, Steven Nusinowitz, Kevin Chao, Fei Yu, Dean Bok

Proc Natl Acad Sci U S A· November 2013

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Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).
Songhua Li, Zhihui Yang, Jane Hu, William C Gordon, Nicolas G Bazan, Dean Bok

J Biol Chem· April 2013

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Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6.
Alberto Ruiz, Manuel Mark, Hugues Jacobs, Muriel Klopfenstein, Jane Hu, Dean Bok

Invest Ophthalmol Vis Sci· May 2012

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Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.
Lincoln V Johnson, David L Forest, Christopher D Banna, Carolyn M Radeke, Michelle A Maloney, Dean Bok

Proc Natl Acad Sci U S A· November 2011

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Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).
Liyo Kao, Lisa M Kurtz, Xuesi Shao, Marios C Papadopoulos, Li Liu, Dean Bok

J Biol Chem· September 2011

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Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration.
Roxana A Radu, Jane Hu, Quan Yuan, Darcy L Welch, Jacob Makshanoff, Dean Bok

J Biol Chem· May 2011

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mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.
Chen Zhao, Douglas Yasumura, Xiyan Li, Michael Matthes, Marcia Lloyd, Dean Bok

J Clin Invest· January 2011

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Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination.
Natalia S Mattan, Cristina A Ghiani, Marcia Lloyd, Reuben Matalon, Dean Bok

Neurobiol Dis· November 2010

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Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells.
Jo-Ling Liao, Juehua Yu, Kevin Huang, Jane Hu, Tanja Diemer, Dean Bok

Hum Mol Genet· November 2010

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