Publications by authors named "Dean Brown"

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What Do Oral Drugs Really Look Like? Dose Regimen, Pharmacokinetics, and Safety of Recently Approved Small-Molecule Oral Drugs.
Dean G Brown

J Med Chem· November 2025

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Current and Emerging Prodrug Strategies.
Dean G Brown, Hyejin Park

J Med Chem· June 2025

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The Importance of Publishing for Industrial Medicinal Chemists.
Dean G Brown

J Med Chem· April 2025

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Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy.
Mari Aikio, Hana M Odeh, Heike J Wobst, Bo Lim Lee, Úna Chan, Dean G Brown

Cell Rep· March 2025

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Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy.
Mari Aikio, Hana M Odeh, Heike J Wobst, Bo Lim Lee, Úna Chan, Dean G Brown

Cell Rep· January 2025

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Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency.
Lara N Gechijian, Giovanni Muncipinto, T Justin Rettenmaier, Matthew T Labenski, Victor Rusu, Dean G Brown

ACS Chem Biol· November 2024

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SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine.
Heike J Wobst, Andreu Viader, Giovanni Muncipinto, Ryan Hollibaugh, Daniel van Kalken, Dean G Brown

JCI Insight· November 2024

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Effect of pre-intercalation on Li-ion diffusion mapped by topochemical single-crystal transformation and operando investigation.
Yuting Luo, Joseph V Handy, Tisita Das, John D Ponis, Ryan Albers, Dean C Brown

Nat Mater· July 2024

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A Drug Discovery Perspective on FDA Expedited Development and Incentive Programs.
Dean G Brown

J Med Chem· February 2024

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Adapting to the Changing Landscape of Biotech-Driven Drug Discovery.
Dean G Brown

J Med Chem· December 2023

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Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors.
Tyler Heitmann, Gangling Liao, Pablo de León, Glen Ernst, Ingrid Buchler, Dean Brown

ACS Med Chem Lett· December 2023

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Correction to "An Analysis of Successful Hit-to-Clinical Candidate Pairs".
Dean G Brown

J Med Chem· July 2023

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An Analysis of Successful Hit-to-Clinical Candidate Pairs.
Dean G Brown

J Med Chem· June 2023

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Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases.
Dean G Brown, Heike J Wobst

Bioorg Med Chem· February 2023

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Some Observations and Guidance on Perspectives in the .
Dean G Brown, Nicholas A Meanwell, Craig W Lindsley

J Med Chem· February 2023

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Clinical development times for innovative drugs.
Dean G Brown, Heike J Wobst, Abhijeet Kapoor, Leslie A Kenna, Noel Southall

Nat Rev Drug Discov· November 2022

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A survey of the clinical pipeline in neuroscience.
Dean G Brown, Heike J Wobst

Bioorg Med Chem Lett· January 2022

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A Decade of FDA-Approved Drugs (2010-2019): Trends and Future Directions.
Dean G Brown, Heike J Wobst

J Med Chem· March 2021

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Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition.
Amanda J Kennedy, Linda Sundström, Stefan Geschwindner, Eunice K Y Poon, Yuhong Jiang, Dean G Brown

Commun Biol· December 2020

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A High-Throughput Cellular Screening Assay for Small-Molecule Inhibitors and Activators of Cytoplasmic Dynein-1-Based Cargo Transport.
John Vincent, Marian Preston, Elizabeth Mouchet, Nicolas Laugier, Adam Corrigan, Dean G Brown

SLAS Discov· October 2020

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The clinical trial landscape in amyotrophic lateral sclerosis-Past, present, and future.
Heike J Wobst, Korrie L Mack, Dean G Brown, Nicholas J Brandon, James Shorter

Med Res Rev· July 2020

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Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons.
M Catarina Silva, Ghata A Nandi, Sharon Tentarelli, Ian K Gurrell, Tanguy Jamier, Dean G Brown

Nat Commun· June 2020

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Axl receptor tyrosine kinase is a regulator of apolipoprotein E.
Wenchen Zhao, Jianjia Fan, Iva Kulic, Cheryl Koh, Amanda Clark, Dean G Brown

Mol Brain· May 2020

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Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia.
Dean G Brown, James Shorter, Heike J Wobst

Bioorg Med Chem Lett· February 2020

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Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition.
Hugo Brito, Vanda Marques, Marta B Afonso, Dean G Brown, Ulf Börjesson

Cell Death Discov· February 2020

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