Publications by authors named "Dean Hallam"

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Retinal cells derived from patients with DRAM2-dependent CORD21 dystrophy exhibit key lysosomal enzyme deficiency and lysosomal content accumulation.
Rozaliya Tsikandelova, Eldo Galo, Edvinas Cerniauskas, Dean Hallam, Maria Georgiou

Stem Cell Reports· August 2024

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Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants.
Nikolaos Tzoumas, Dean Hallam, Claire L Harris, Majlinda Lako, David Kavanagh

Surv Ophthalmol· March 2022

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Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function.
Edvinas Cerniauskas, Marzena Kurzawa-Akanbi, Long Xie, Dean Hallam, Marina Moya-Molina

Stem Cells Transl Med· December 2020

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Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids.
Birthe Dorgau, Majed Felemban, Gerrit Hilgen, Martin Kiening, Darin Zerti, Dean Hallam

Biomaterials· April 2019

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An integrated transcriptional analysis of the developing human retina.
Carla B Mellough, Roman Bauer, Joseph Collin, Birthe Dorgau, Darin Zerti, Dean Hallam

Development· January 2019

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The Application of Biomaterials to Tissue Engineering Neural Retina and Retinal Pigment Epithelium.
Nicola C Hunt, Dean Hallam, Valeria Chichagova, David H Steel, Majlinda Lako

Adv Healthc Mater· December 2018

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CD200 Expression Marks a Population of Quiescent Limbal Epithelial Stem Cells with Holoclone Forming Ability.
Sanja Bojic, Dean Hallam, Nuno Alcada, Ali Ghareeb, Rachel Queen

Stem Cells· November 2018

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Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency.
Dean Hallam, Gerrit Hilgen, Birthe Dorgau, Lili Zhu, Min Yu

Stem Cells· October 2018

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Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.
Adriana Buskin, Lili Zhu, Valeria Chichagova, Basudha Basu, Sina Mozaffari-Jovin, Dean Hallam

Nat Commun· October 2018

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Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.
Majed Felemban, Birthe Dorgau, Nicola Claire Hunt, Dean Hallam, Darin Zerti

Acta Biomater· July 2018

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Cellular regeneration strategies for macular degeneration: past, present and future.
Valeria Chichagova, Dean Hallam, Joseph Collin, Darin Zerti, Birthe Dorgau

Eye (Lond)· May 2018

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Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation.
Birthe Dorgau, Majed Felemban, Alexander Sharpe, Roman Bauer, Dean Hallam

Cell Death Dis· May 2018

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In Reply to the Letter to the Editor from Anderson et al.: An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.
Dean Hallam, David Rawlings, David Steel, Lyle Armstrong, Majlinda Lako

Stem Cells· April 2018

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An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.
Dean Hallam, Joseph Collin, Sanja Bojic, Valeria Chichagova, Adriana Buskin

Stem Cells· November 2017

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Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A > G mitochondrial DNA mutation.
Valeria Chichagova, Dean Hallam, Joseph Collin, Adriana Buskin, Gabriele Saretzki

Sci Rep· September 2017

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3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development.
Nicola C Hunt, Dean Hallam, Ayesha Karimi, Carla B Mellough, Jinju Chen

Acta Biomater· February 2017

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Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium.
Dean Hallam, Tengfei Wan, Gabriele Saretzki

Exp Gerontol· July 2015

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