Publications by authors named "Dean W Hum"

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Impact of age on NIS2+™ and other non-invasive blood tests for the evaluation of liver disease and detection of at-risk MASH.
Quentin M Anstee, Jeremy Magnanensi, Yacine Hajji, Alexandra Caron, Zouher Majd, Dean W Hum

JHEP Rep· April 2024

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NIS2+™, an optimisation of the blood-based biomarker NIS4® technology for the detection of at-risk NASH: A prospective derivation and validation study.
Stephen A Harrison, Vlad Ratziu, Jeremy Magnanensi, Yacine Hajji, Sylvie Deledicque, Dean W Hum

J Hepatol· September 2023

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A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study.
Stephen A Harrison, Vlad Ratziu, Jérôme Boursier, Sven Francque, Pierre Bedossa, Dean W Hum

Lancet Gastroenterol Hepatol· November 2020

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Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits.
Markus P Kummer, Rafael Schwarzenberger, Sakina Sayah-Jeanne, Mathieu Dubernet, Robert Walczak, Dean W Hum

Mol Neurobiol· April 2015

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The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.
Rémy Hanf, Lesley J Millatt, Bertrand Cariou, Benoit Noel, Géraldine Rigou, Dean W Hum

Diab Vasc Dis Res· November 2014

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The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).
Stéphane Helleboid, Christian Haug, Kai Lamottke, Yijun Zhou, Jianbing Wei, Dean W Hum

J Biomol Screen· March 2014

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Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Bart Staels, Anne Rubenstrunk, Benoit Noel, Géraldine Rigou, Philippe Delataille, Dean W Hum

Hepatology· December 2013

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Antipsychotic drug action on SREBPs-related lipogenesis and cholesterogenesis in primary rat hepatocytes.
Emilie Lauressergues, Bart Staels, Karine Valeille, Zouher Majd, Dean W Hum

Naunyn Schmiedebergs Arch Pharmacol· May 2010

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Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
Romain Gineste, Audrey Sirvent, Réjane Paumelle, Stéphane Helleboid, Alexis Aquilina, Dean W Hum

Mol Endocrinol· November 2008

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Safety issues and prospects for future generations of PPAR modulators.
Anne Rubenstrunk, Rémy Hanf, Dean W Hum, Jean-Charles Fruchart, Bart Staels

Biochim Biophys Acta· August 2007

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TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.
Florence Gizard, Romain Robillard, Barbara Gross, Olivier Barbier, Françoise Révillion, Dean W Hum

Mol Cell Biol· October 2006

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Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha.
Annelise Genoux, Hélène Dehondt, Audrey Helleboid-Chapman, Christian Duhem, Dean W Hum

Arterioscler Thromb Vasc Biol· June 2005

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TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1.
Florence Gizard, Romain Robillard, Olivier Barbier, Brigitte Quatannens, Anne Faucompré, Dean W Hum

Mol Cell Biol· June 2005

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Farnesoid X receptor represses hepatic lipase gene expression.
Audrey Sirvent, Adrie J M Verhoeven, Hans Jansen, Vladimir Kosykh, Raphaël J Darteil, Dean W Hum

J Lipid Res· November 2004

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The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c.
Heidelinde Jakel, Maxime Nowak, Emanuelle Moitrot, Hélène Dehondt, Dean W Hum

J Biol Chem· October 2004

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The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
Audrey Sirvent, Thierry Claudel, Geneviève Martin, John Brozek, Vladimir Kosykh, Dean W Hum

FEBS Lett· May 2004

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Lesion progression in apoE-deficient mice: implication of chemokines and effect of the AT1 angiotensin II receptor antagonist irbesartan.
Geneviève Martin, Frédérique Dol, Anne-Marie Marés, Vincent Berezowski, Bart Staels, Dean W Hum

J Cardiovasc Pharmacol· February 2004

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Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression.
Florence Gizard, Mohamed El-Alfy, Yannick Duguay, Bernard Lavallée, Fredérique DeWitte, Dean W Hum

Endocr Res· November 2002

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The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells.
Florence Gizard, Bernard Lavallee, Frederique DeWitte, Elisabeth Teissier, Bart Staels, Dean W Hum

J Biol Chem· October 2002

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Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
Thierry Claudel, Ekkehard Sturm, Hélène Duez, Inés Pineda Torra, Audrey Sirvent, Dean W Hum

J Clin Invest· April 2002

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