Publications by authors named "Debananda Das"

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An orally available P1'-5-fluorinated M inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier.
Nobuyo Higashi-Kuwata, Haydar Bulut, Hironori Hayashi, Kohei Tsuji, Hiromi Ogata-Aoki, Debananda Das, Tadashi Okamura

PNAS Nexus· January 2025

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HIV-1 protease inhibitors and mechanisms of HIV-1's resistance.
Debananda Das

Glob Health Med· December 2024

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GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.
Manabu Aoki, Hiromi Aoki-Ogata, Haydar Bulut, Hironori Hayashi, Nobutoki Takamune, Debananda Das

Sci Adv· July 2023

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Synthesis of novel entecavir analogues having 4'-cyano-6''-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent.
Hiroki Kumamoto, Nobuyo Higashi-Kuwata, Sanae Hayashi, Debananda Das, Haydar Bulut

RSC Adv· May 2023

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Identification of SARS-CoV-2 M inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.
Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Debananda Das, Tadashi Okamura

Nat Commun· February 2023

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Potent and biostable inhibitors of the main protease of SARS-CoV-2.
Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Debananda Das, Tadashi Okamura

iScience· November 2022

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Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.
Nobuyo Higashi-Kuwata, Sanae Hayashi, Hiroki Kumamoto, Hiromi Ogata-Aoki, Debananda Das

J Hepatol· May 2021

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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Shin-Ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Debananda Das

Nat Commun· January 2021

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Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.
Kengo Onitsuka, Ryoh Tokuda, Nobuyo Kuwata-Higashi, Hiroki Kumamoto, Manabu Aoki, Debananda Das

Nucleosides Nucleotides Nucleic Acids· December 2020

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GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection.
Shin-Ichiro Hattori, Nobuyo Higshi-Kuwata, Jakka Raghavaiah, Debananda Das, Haydar Bulut, Tadashi Okamura

mBio· August 2020

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Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity.
Haydar Bulut, Shin-Ichiro Hattori, Hiromi Aoki-Ogata, Hironori Hayashi, Debananda Das

Sci Rep· June 2020

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7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety.
Sanae Hayashi, Nobuyo Higashi-Kuwata, Debananda Das, Kota Tomaya, Kohei Yamada

Antiviral Res· April 2020

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Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication.
Kenji Maeda, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura, Hiroaki Takeuchi

Curr Top Med Chem· November 2019

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A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance.
Manabu Aoki, Simon B Chang, Debananda Das, Cuthbert Martyr, Nicole S Delino

Glob Health Med· October 2019

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Novel Protease Inhibitors Containing C-5-Modified -Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2' Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance.
Yuki Takamatsu, Manabu Aoki, Haydar Bulut, Debananda Das, Masayuki Amano

Antimicrob Agents Chemother· August 2019

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CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.
Nobuyo Higashi-Kuwata, Sanae Hayashi, Debananda Das, Satoru Kohgo, Shuko Murakami

Antimicrob Agents Chemother· April 2019

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Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s.
Hirotomo Nakata, Kenji Maeda, Debananda Das, Simon B Chang, Kouki Matsuda

Sci Rep· March 2019

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The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase.
Yuki Takamatsu, Debananda Das, Satoru Kohgo, Hironori Hayashi, Nicole S Delino

Cell Chem Biol· October 2018

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GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants.
Nicole S Delino, Manabu Aoki, Hironori Hayashi, Shin-Ichiro Hattori, Simon B Chang, Debananda Das

Antimicrob Agents Chemother· May 2018

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Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.
Manabu Aoki, Debananda Das, Hironori Hayashi, Hiromi Aoki-Ogata, Yuki Takamatsu

mBio· March 2018

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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.
Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao, Debananda Das, Nobuyo Higashi-Kuwata

Elife· October 2017

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Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.
Arun K Ghosh, Kalapala Venkateswara Rao, Prasanth R Nyalapatla, Heather L Osswald, Cuthbert D Martyr, Debananda Das

J Med Chem· May 2017

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A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.
Masayuki Amano, Pedro Miguel Salcedo-Gómez, Rui Zhao, Ravikiran S Yedidi, Debananda Das

Antimicrob Agents Chemother· December 2016

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C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.
Manabu Aoki, Hironori Hayashi, Ravikiran S Yedidi, Cuthbert D Martyr, Yuki Takamatsu, Debananda Das

J Virol· November 2015

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4'-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.
Yuki Takamatsu, Yasuhito Tanaka, Satoru Kohgo, Shuko Murakami, Kamalendra Singh, Debananda Das

Hepatology· October 2015

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