Publications by authors named "Deborah Guest"

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Inhibition of interleukin-1 receptor-associated kinase (IRAK)-4 provides partial rescue of interleukin-1 beta induced functional and gene expression changes in equine tenocytes.
Ross Eric Beaumont, Caroline Flood, Deborah Jane Guest

Mol Biol Rep· November 2025

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A review of the equine suspensory ligament: Injury prone yet understudied.
Deborah J Guest, Helen L Birch, Chavaunne T Thorpe

Equine Vet J· September 2025

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Equine adult, fetal and ESC-tenocytes have differential migratory, proliferative and gene expression responses to factors upregulated in the injured tendon.
Ross E Beaumont, Emily J Smith, Clara David, Yasmin Z Paterson, Elena Faull, Deborah J Guest

Cells Dev· March 2025

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Identification of a global gene expression signature associated with the genetic risk of catastrophic fracture in iPSC-derived osteoblasts from Thoroughbred horses.
Esther Palomino Lago, Amy K C Ross, Alyce McClellan, Deborah J Guest

Anim Genet· February 2025

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CRISPR/Cas9 gene editing in induced pluripotent stem cells to investigate the feline hypertrophic cardiomyopathy causing MYBPC3/R820W mutation.
Luke C Dutton, Jayesh Dudhia, Deborah J Guest, David J Connolly

PLoS One· October 2024

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Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling.
Ross Eric Beaumont, Emily Josephine Smith, Lexin Zhou, Neil Marr, Chavaunne T Thorpe, Deborah Jane Guest

Mol Cell Biochem· May 2024

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Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes.
Emily J Smith, Ross E Beaumont, Jayesh Dudhia, Deborah J Guest

Stem Cell Rev Rep· May 2024

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A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses.
Esther Palomino Lago, Arabella Baird, Sarah C Blott, Rhona E McPhail, Amy C Ross, Deborah J Guest

Animals (Basel)· December 2023

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Equine induced pluripotent stem cells are responsive to inflammatory cytokines before and after differentiation into musculoskeletal cell types.
Esther Palomino Lago, Elizabeth R Jelbert, Arabella Baird, Pak Y Lam, Deborah J Guest

In Vitro Cell Dev Biol Anim· August 2023

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Influence of Rho/ROCK inhibitor Y-27632 on proliferation of equine mesenchymal stromal cells.
Michaela Melzer, Janina Burk, Deborah J Guest, Jayesh Dudhia

Front Vet Sci· June 2023

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Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors.
Emily J Smith, Ross E Beaumont, Alyce McClellan, Cheryl Sze, Esther Palomino Lago, Deborah J Guest

Cell Tissue Res· March 2023

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Integrating external beam and prostate seed implant dosimetry for intermediate and high-risk prostate cancer using biologically effective dose: Impact of image registration technique.
Adam C Riegel, Ann Cooney, Samantha To, Deborah Guest, Brisca Lee

Brachytherapy· December 2022

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Cyclical strain improves artificial equine tendon constructs in vitro.
Francesca Atkinson, Richard Evans, James E Guest, Emma P Bavin, Diogo Cacador, Deborah J Guest

J Tissue Eng Regen Med· May 2020

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Canine Corneal Stromal Cells Have Multipotent Mesenchymal Stromal Cell Properties In Vitro.
Christiane Kafarnik, Alyce McClellan, Marc Dziasko, Julie T Daniels, Deborah J Guest

Stem Cells Dev· April 2020

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Synthesis and Formulation of Four-Arm PolyDMAEA-siRNA Polyplex for Transient Downregulation of Collagen Type III Gene Expression in TGF-β1 Stimulated Tenocyte Culture.
Xin Liao, Noelia D Falcon, Ali A Mohammed, Yasmin Z Paterson, Andrew Geoffrey Mayes, Deborah J Guest

ACS Omega· January 2020

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Equine Fetal, Adult, and Embryonic Stem Cell-Derived Tenocytes Are All Immune Privileged but Exhibit Different Immune Suppressive Properties In Vitro.
Alyce McClellan, Yasmin Z Paterson, Romain Paillot, Deborah Jane Guest

Stem Cells Dev· November 2019

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Inducing Pluripotency in the Domestic Cat ().
Luke C Dutton, Jayesh Dudhia, Deborah J Guest, David J Connolly

Stem Cells Dev· October 2019

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Biocompatible Three-Dimensional Printed Thermoplastic Scaffold for Osteoblast Differentiation of Equine Induced Pluripotent Stem Cells.
Arabella Baird, Noelia Dominguez Falcon, Aram Saeed, Deborah Jane Guest

Tissue Eng Part C Methods· May 2019

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A novel mechanism for the protection of embryonic stem cell derived tenocytes from inflammatory cytokine interleukin 1 beta.
Alyce McClellan, Richard Evans, Cheryl Sze, Shohei Kan, Yasmin Paterson, Deborah Guest

Sci Rep· February 2019

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Osteoblast differentiation of equine induced pluripotent stem cells.
Arabella Baird, Timothy Lindsay, Alice Everett, Valentine Iyemere, Yasmin Z Paterson, Deborah J Guest

Biol Open· May 2018

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Equine Induced Pluripotent Stem Cells have a Reduced Tendon Differentiation Capacity Compared to Embryonic Stem Cells.
Emma P Bavin, Olivia Smith, Arabella E G Baird, Lawrence C Smith, Deborah J Guest

Front Vet Sci· December 2015

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Comparison of autologous versus allogeneic epithelial-like stem cell treatment in an in vivo equine skin wound model.
Sarah Y Broeckx, Bizunesh M Borena, Lore Van Hecke, Koen Chiers, Sofie Maes, Deborah J Guest

Cytotherapy· October 2015

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Equine mesenchymal stromal cells and embryo-derived stem cells are immune privileged in vitro.
Yasmin Z Paterson, Nicola Rash, Elaine R Garvican, Romain Paillot, Deborah J Guest

Stem Cell Res Ther· July 2014

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Defining the expression of marker genes in equine mesenchymal stromal cells.
Deborah J Guest, Jennifer C Ousey, Matthew Rw Smith

Stem Cells Cloning· November 2013

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Tendon regeneration in human and equine athletes: Ubi Sumus-Quo Vadimus (where are we and where are we going to)?
Jan H Spaas, Deborah J Guest, Gerlinde R Van de Walle

Sports Med· October 2012

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