Publications by authors named "Deborah Hung"

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Longitudinal Antibody Responses to SARS-CoV-2 Infection in Children: Impact of Age, Vaccines and Symptoms.
Peijun Ma, Philip D Chen, Sakshee Jadhav, Lorrie L He, Hannah H Laibinis, Deborah T Hung

Pediatr Infect Dis J· December 2025

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A Multiplexed, Target-Based Phenotypic Screening Platform Using CRISPR Interference in .
Donavan Marcus Neo, Ishay Ben-Zion, Josephine Bagnall, Matthew Y Solomon, Austin N Bond, Deborah T Hung

ACS Infect Dis· November 2025

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Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis.
Austin N Bond, Marek Orzechowski, Shuting Zhang, Ishay Ben-Zion, Allison Lemmer, Deborah T Hung

Nat Commun· November 2025

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Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosome.
Gerard Wright, Michael Cook, Min Xu, Martino Morici, Dmitrii Travin, Deborah Hung

Res Sq· November 2025

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Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism.
Emily R Goering, Anne E Clatworthy, Margarita Parada-Kusz, Josephine Bagnall, Deborah T Hung

PLoS Pathog· October 2025

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An Inducible CRISPRi system for phenotypic analysis of essential genes in Pseudomonas aeruginosa.
Jaryd R Sullivan, Kristina Ferrara, Rebecca Barrick, Keith P Romano, Thulasi Warrier, Deborah T Hung

bioRxiv· September 2025

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Mapping genetic and phenotypic diversity of across clinical and environmental isolation sites.
Cristina Penaranda, Evan P Brenner, Anne E Clatworthy, Lisa A Cosimi, Janani Ravi, Deborah T Hung

bioRxiv· September 2025

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A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
Kamil Slowikowski, Pritha Sen, Christopher V Cosgriff, Jessica Tantivit, Tom Eisenhaure, Deborah Hung

medRxiv· September 2025

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Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens.
Megan W Tse, Meilin Zhu, Benjamin Peters, Efrat Hamami, Julie Chen, Deborah T Hung

Proc Natl Acad Sci U S A· April 2025

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Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A.
Nitesh Kumar Khandelwal, Meghna Gupta, James E Gomez, Sulyman Barkho, Ziqiang Guan, Deborah T Hung

Nat Commun· April 2025

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Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers.
Amandine Sury, Margo Maex, Alain Baulard, Roby P Bhattacharyya, Stéphanie Depickère, Deborah T Hung

EBioMedicine· March 2025

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A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.
Yered Pita-Juarez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C Melms, Sebastian Niezen, Deborah Hung

Genome Biol· March 2025

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Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.
Bradley E Poulsen, Thulasi Warrier, Sulyman Barkho, Josephine Bagnall, Keith P Romano, Deborah T Hung

Cell Chem Biol· February 2025

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3-Hydroxykynurenine targets kainate receptors to promote defense against infection.
Margarita Parada-Kusz, Anne E Clatworthy, Emily R Goering, Stephanie M Blackwood, Jack Y Shigeta, Deborah T Hung

Nat Chem Biol· December 2024

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Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa.
Conrad A Fihn, Hannah K Lembke, Jeffrey Gaulin, Patricia Bouchard, Alex R Villarreal, Deborah T Hung

Bioorg Chem· December 2024

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Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics.
Keith P Romano, Josephine Bagnall, Thulasi Warrier, Jaryd Sullivan, Kristina Ferrara, Deborah T Hung

Proc Natl Acad Sci U S A· November 2024

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Protein interactions in human pathogens revealed through deep learning.
Ian R Humphreys, Jing Zhang, Minkyung Baek, Yaxi Wang, Aditya Krishnakumar, Deborah T Hung

Nat Microbiol· October 2024

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8-Hydroxyquinoline Series Exerts Bactericidal Activity against Via Copper-Mediated Toxicity.
Amala Bhagwat, Arielle Butts, Eric Greve, Yan Cheung, Eduard Melief, Deborah T Hung

ACS Infect Dis· October 2024

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Structure and inhibition mechanisms of essential transporter efflux protein A.
Nitesh Kumar Khandelwal, Meghna Gupta, James E Gomez, Sulyman Barkho, Ziqiang Guan, Deborah T Hung

bioRxiv· September 2024

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Fluorogenic Probes of the Mycobacterial Membrane as Reporters of Antibiotic Action.
Michael G Wuo, Charles L Dulberger, Theodore C Warner, Robert A Brown, Alexander Sturm, Deborah T Hung

J Am Chem Soc· July 2024

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Perturbation-Specific Transcriptional Mapping for unbiased target elucidation of antibiotics.
Keith P Romano, Josephine Bagnall, Thulasi Warrier, Jaryd Sullivan, Kristina Ferrara, Deborah Hung

bioRxiv· June 2024

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Essential and virulence-related protein interactions of pathogens revealed through deep learning.
Ian R Humphreys, Jing Zhang, Minkyung Baek, Yaxi Wang, Aditya Krishnakumar, Deborah T Hung

bioRxiv· April 2024

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A dual-plasmid CRISPR/Cas9-based method for rapid and efficient genetic disruption in .
Donavan Marcus Neo, Anne E Clatworthy, Deborah T Hung

J Bacteriol· March 2024

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"Multiplexed screen identifies a -specific small molecule targeting the outer membrane protein OprH and its interaction with LPS".
Bradley E Poulsen, Thulasi Warrier, Sulyman Barkho, Josephine Bagnall, Keith P Romano, Deborah T Hung

bioRxiv· March 2024

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Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens.
Megan W Tse, Meilin Zhu, Benjamin Peters, Efrat Hamami, Julie Chen, Deborah T Hung

bioRxiv· March 2024

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