Publications by authors named "Deborah Ngan"

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Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity.
Xi Luo, Li Zhang, Srilatha Sakamuru, Precious A Adesina, Jinghua Zhao, Deborah K Ngan

Toxicol Appl Pharmacol· September 2025

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Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation.
Deborah K Ngan, Srilatha Sakamuru, Jinghua Zhao, Menghang Xia, Stephen S Ferguson

Toxicol Appl Pharmacol· June 2025

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Expanded Tox21 biological assay panel for the prediction of drug-induced liver injury and cardiotoxicity.
Tuan Xu, Masato Ooka, Jinghua Zhao, Srilatha Sakamuru, Deborah K Ngan, Tongan Zhao

Environ Health Perspect· June 2025

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Systematic identification of cancer pathways and potential drugs for intervention through multi-omics analysis.
Tuan Xu, Deborah K Ngan, Wei Zheng, Ruili Huang

Pharmacogenomics J· February 2025

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Prediction of chemical-induced acute toxicity using in vitro assay data and chemical structure.
Xi Luo, Tuan Xu, Deborah K Ngan, Menghang Xia, Jinghua Zhao

Toxicol Appl Pharmacol· November 2024

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Evaluating the Utility of the MSTI Assay in Predicting Compound Promiscuity and Cytotoxicity.
Laken Kruger, Deborah K Ngan, Tuan Xu, Li Zhang, Menghang Xia

Chem Res Toxicol· October 2024

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In vitro profiling of pesticides within the Tox21 10K compound library for bioactivity and potential toxicity.
Deborah K Ngan, Menghang Xia, Anton Simeonov, Ruili Huang

Toxicol Appl Pharmacol· August 2023

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Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Deborah K Ngan

ACS Pharmacol Transl Sci· May 2023

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Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates.
Tuan Xu, Md Kabir, Srilatha Sakamuru, Pranav Shah, Elias C Padilha, Deborah K Ngan

J Chem Inf Model· February 2023

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Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data.
Lin Ye, Deborah K Ngan, Tuan Xu, Zhichao Liu, Jinghua Zhao, Tongan Zhao

Toxicol Appl Pharmacol· November 2022

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Repurposing drugs as COVID-19 therapies: A toxicity evaluation.
Deborah K Ngan, Tuan Xu, Menghang Xia, Wei Zheng, Ruili Huang

Drug Discov Today· July 2022

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Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics.
Hu Zhu, Catherine Z Chen, Srilatha Sakamuru, Jinghua Zhao, Deborah K Ngan

Sci Rep· March 2021

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Predictive Models for Human Organ Toxicity Based on Bioactivity Data and Chemical Structure.
Tuan Xu, Deborah K Ngan, Lin Ye, Menghang Xia, Heidi Q Xie

Chem Res Toxicol· March 2020

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The NCATS Pharmaceutical Collection: a 10-year update.
Ruili Huang, Hu Zhu, Paul Shinn, Deborah Ngan, Lin Ye, Tongan Zhao

Drug Discov Today· December 2019

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Bioactivity Signatures of Drugs vs. Environmental Chemicals Revealed by Tox21 High-Throughput Screening Assays.
Deborah K Ngan, Lin Ye, Leihong Wu, Menghang Xia, Anna Rossoshek

Front Big Data· December 2019

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The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics.
Ruili Huang, Ivan Grishagin, Yuhong Wang, Tongan Zhao, Jon Greene, Deborah Ngan

Front Pharmacol· April 2019

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