Publications by authors named "Deborah Siwik"

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Effects of Sodium-Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice.
Dominique Croteau, Ivan Luptak, Jordan M Chambers, Ion Hobai, Marcello Panagia, Deborah A Siwik

J Am Heart Assoc· July 2021

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Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice.
Jena B Goodman, Fuzhong Qin, Robert J Morgan, Jordan M Chambers, Dominique Croteau, Deborah A Siwik

Circulation· December 2020

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Differential Effects of Sacubitril/Valsartan on Diastolic Function in Mice With Obesity-Related Metabolic Heart Disease.
Dominique Croteau, Fuzhong Qin, Jordan M Chambers, Ethan Kallick, Ivan Luptak, Deborah A Siwik

JACC Basic Transl Sci· September 2020

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Energetic Dysfunction Is Mediated by Mitochondrial Reactive Oxygen Species and Precedes Structural Remodeling in Metabolic Heart Disease.
Ivan Luptak, Fuzhong Qin, Aaron L Sverdlov, David R Pimentel, Marcello Panagia, Deborah A Siwik

Antioxid Redox Signal· September 2019

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Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis.
Ivan Luptak, Dominique Croteau, Catherine Valentine, Fuzhong Qin, Deborah A Siwik

Shock· July 2019

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Galectin-3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients.
Deepa M Gopal, Nir Ayalon, Yi-Chih Wang, Deborah Siwik, Aaron Sverdlov

J Am Heart Assoc· April 2019

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Decreased ATP production and myocardial contractile reserve in metabolic heart disease.
Ivan Luptak, Aaron L Sverdlov, Marcello Panagia, Fuzhong Qin, David R Pimentel, Deborah A Siwik

J Mol Cell Cardiol· March 2018

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Up-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice.
Justin C Morse, Joanne Huang, Natasha Khona, Edward J Miller, Deborah A Siwik

Anesthesiology· June 2017

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Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice.
Ion A Hobai, Kanwal Aziz, Emmanuel S Buys, Peter Brouckaert, Deborah A Siwik

Shock· December 2016

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Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins.
Chunxiang Yao, Jessica B Behring, Di Shao, Aaron L Sverdlov, Stephen A Whelan, Deborah A Siwik

PLoS One· June 2016

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Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease.
Aaron L Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B Behring, Ivan Luptak, Deborah A Siwik

J Am Heart Assoc· January 2016

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The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling.
Timothy D Calamaras, Charlie Lee, Fan Lan, Yasuo Ido, Deborah A Siwik

Free Radic Biol Med· May 2015

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Lipopolysaccharide and cytokines inhibit rat cardiomyocyte contractility in vitro.
Ion A Hobai, Justin C Morse, Deborah A Siwik, Wilson S Colucci

J Surg Res· February 2015

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High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II.
Aaron L Sverdlov, Aly Elezaby, Jessica B Behring, Markus M Bachschmid, Ivan Luptak, Deborah A Siwik

J Mol Cell Cardiol· January 2015

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Does reversible cysteine oxidation link the Western diet to cardiac dysfunction?
Jessica B Behring, Vikas Kumar, Stephen A Whelan, Pratibha Chauhan, Deborah A Siwik

FASEB J· May 2014

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Cytosolic H2O2 mediates hypertrophy, apoptosis, and decreased SERCA activity in mice with chronic hemodynamic overload.
Fuzhong Qin, Deborah A Siwik, David R Pimentel, Robert J Morgan, Andreia Biolo

Am J Physiol Heart Circ Physiol· May 2014

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SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis.
Ion A Hobai, Emmanuel S Buys, Justin C Morse, Jessica Edgecomb, Eric H Weiss, Deborah A Siwik

Am J Physiol Heart Circ Physiol· October 2013

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Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart.
Fuzhong Qin, Deborah A Siwik, Steve Lancel, Jingmei Zhang, Gabriela M Kuster

J Am Heart Assoc· August 2013

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Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity.
Timothy D Calamaras, Charlie Lee, Fan Lan, Yasuo Ido, Deborah A Siwik

J Biol Chem· December 2012

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Relationship of plasma galectin-3 to renal function in patients with heart failure: effects of clinical status, pathophysiology of heart failure, and presence or absence of heart failure.
Deepa M Gopal, Maya Kommineni, Nir Ayalon, Christian Koelbl, Rivka Ayalon, Deborah A Siwik

J Am Heart Assoc· October 2012

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The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice.
Fuzhong Qin, Deborah A Siwik, Ivan Luptak, Xiuyun Hou, Lei Wang

Circulation· April 2012

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Dynamics in insulin resistance and plasma levels of adipokines in patients with acute decompensated and chronic stable heart failure.
P Christian Schulze, Andreia Biolo, Deepa Gopal, Khurram Shahzad, Joshua Balog, Deborah Siwik

J Card Fail· December 2011

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Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion.
Marc Liesa, Ivan Luptak, Fuzhong Qin, Brigham B Hyde, Ergun Sahin, Deborah A Siwik

Circulation· August 2011

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Relations of biomarkers of extracellular matrix remodeling to incident cardiovascular events and mortality.
Raghava S Velagaleti, Philimon Gona, Johan Sundström, Martin G Larson, Deborah Siwik

Arterioscler Thromb Vasc Biol· November 2010

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Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice.
Steve Lancel, Fuzhong Qin, Shannon L Lennon, Jingmei Zhang, Xiaoyong Tong, Deborah A Siwik

Circ Res· July 2010

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