Publications by authors named "Debra A Cheng"

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Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.
Judith F Ashouri, Lih-Yun Hsu, Steven Yu, Dmitry Rychkov, Yiling Chen, Debra A Cheng

Proc Natl Acad Sci U S A· September 2019

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Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.
Lih-Yun Hsu, Debra A Cheng, Yiling Chen, Hong-Erh Liang, Arthur Weiss

J Exp Med· March 2017

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The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
Hanna Sjölin Goodfellow, Maria P Frushicheva, Qinqin Ji, Debra A Cheng, Theresa A Kadlecek

Sci Signal· May 2015

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A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
Byron B Au-Yeung, Julie Zikherman, James L Mueller, Judith F Ashouri, Mehrdad Matloubian, Debra A Cheng

Proc Natl Acad Sci U S A· September 2014

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Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
Byron B Au-Yeung, Heather J Melichar, Jenny O Ross, Debra A Cheng, Julie Zikherman

Nat Immunol· July 2014

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A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
Byron B Au-Yeung, Susan E Levin, Chao Zhang, Lih-Yun Hsu, Debra A Cheng

Nat Immunol· December 2010

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