Publications by authors named "Debra A Thompson"

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Addressing Challenges in Developing Treatments for Inherited Retinal Diseases: Recommendations From the Third Monaciano Symposium.
Debra A Thompson, K Thiran Jayasundera, Oleg Alekseev, Robin R Ali, Alessia Amato

Transl Vis Sci Technol· August 2025

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Reduced Retinal Pigment Epithelial Autophagy Due to Loss of Rab12 Prenylation in a Human iPSC-RPE Model of Choroideremia.
Maide Ö Raeker, Nirosha D Perera, Athanasios J Karoukis, Lisheng Chen, Kecia L Feathers, Debra A Thompson

Cells· June 2024

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Gene Supplementation in Mice Heterozygous for the D477G RPE65 Variant Implicated in Autosomal Dominant Retinitis Pigmentosa.
Kecia L Feathers, Lin Jia, Naheed W Khan, Alexander J Smith, Jian-Xing Ma, Debra A Thompson

Hum Gene Ther· July 2023

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AUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY.
Paloma B Liton, Kathleen Boesze-Battaglia, Michael E Boulton, Patricia Boya, Thomas A Ferguson, Debra A Thompson

Autophagy Rep· March 2023

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Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells.
Lisheng Chen, N Dayanthi Perera, Athanasios J Karoukis, Kecia L Feathers, Robin R Ali, Debra A Thompson

Sci Rep· July 2022

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Pharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration.
Qitao Zhang, Feriel Presswalla, Robin R Ali, David N Zacks, Debra A Thompson

Aging (Albany NY)· April 2021

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Relative Contributions of All-Trans and 11-Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium.
Nicholas P Boyer, Debra A Thompson, Yiannis Koutalos

Invest Ophthalmol Vis Sci· February 2021

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Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium.
Debra A Thompson, Alessandro Iannaccone, Robin R Ali, Vadim Y Arshavsky, Isabelle Audo

Transl Vis Sci Technol· June 2020

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Natural History and Genotype-Phenotype Correlations in RDH12-Associated Retinal Degeneration.
Abigail T Fahim, Debra A Thompson

Adv Exp Med Biol· February 2020

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Detailed clinical characterisation, unique features and natural history of autosomal recessive -associated retinal degeneration.
Abigail T Fahim, Zaina Bouzia, Kari H Branham, Neruban Kumaran, Mauricio E Vargas, Debra A Thompson

Br J Ophthalmol· December 2019

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Development of a Gene Therapy Vector for -Associated Retinal Dystrophy.
Kecia L Feathers, Lin Jia, Nirosha Dayanthi Perera, Adrienne Chen, Feriel K Presswalla, Debra A Thompson

Hum Gene Ther· November 2019

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Inhibiting autophagy reduces retinal degeneration caused by protein misfolding.
Jingyu Yao, Yaoyan Qiu, Eric Frontera, Lin Jia, Naheed W Khan, Debra A Thompson

Autophagy· October 2019

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Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material.
Qitao Zhang, Feriel Presswalla, Melissa Calton, Carol Charniga, Jeffrey Stern, Debra A Thompson

Invest Ophthalmol Vis Sci· August 2019

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Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis.
Yaoyan Qiu, Jingyu Yao, Lin Jia, Debra A Thompson, David N Zacks

Cell Death Dis· July 2019

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A platform for assessing outer segment fate in primary human fetal RPE cultures.
Qitao Zhang, Feriel Presswalla, Kecia Feathers, Xu Cao, Bret A Hughes, Debra A Thompson

Exp Eye Res· January 2019

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Interphotoreceptor retinoid-binding protein removes all--retinol and retinal from rod outer segments, preventing lipofuscin precursor formation.
Chunhe Chen, Leopold Adler, Patrice Goletz, Federico Gonzalez-Fernandez, Debra A Thompson

J Biol Chem· November 2017

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Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.
Jingyu Yao, Lin Jia, Naheed Khan, Chengmao Lin, Sayak K Mitter, Debra A Thompson

Autophagy· April 2016

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MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.
Shameka J Shelby, Kecia L Feathers, Anna M Ganios, Lin Jia, Jason M Miller, Debra A Thompson

Exp Eye Res· November 2015

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Association of Geroprotective Effects of Metformin and Risk of Open-Angle Glaucoma in Persons With Diabetes Mellitus.
Hsien-Chang Lin, Joshua D Stein, Bin Nan, David Childers, Paula Anne Newman-Casey, Debra A Thompson

JAMA Ophthalmol· August 2015

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Long-term effect of gene therapy on Leber's congenital amaurosis.
James W B Bainbridge, Manjit S Mehat, Venki Sundaram, Scott J Robbie, Susie E Barker, Debra A Thompson

N Engl J Med· May 2015

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Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium.
Debra A Thompson, Robin R Ali, Eyal Banin, Kari E Branham, John G Flannery

Invest Ophthalmol Vis Sci· February 2015

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Circadian and noncircadian modulation of autophagy in photoreceptors and retinal pigment epithelium.
Jingyu Yao, Lin Jia, Shameka J Shelby, Anna M Ganios, Kecia Feathers, Debra A Thompson

Invest Ophthalmol Vis Sci· April 2014

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MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.
Shameka J Shelby, Karen Colwill, Sirano Dhe-Paganon, Tony Pawson, Debra A Thompson

PLoS One· July 2013

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Autophagy and gene therapy combine in the treatment of liver disease.
Debra A Thompson, Daniel J Klionsky

Autophagy· July 2013

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Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12.
Chunhe Chen, Debra A Thompson, Yiannis Koutalos

J Biol Chem· July 2012

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