Publications by authors named "Debra F Higgins"

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Clinical validation of a biopsy-based six-gene signature prognostic for aggressive prostate cancer.
Agnieszka Krzyzanowska, Debra F Higgins, Stephen Barron, Tony Loughman, Amanda O'Neill

BJUI Compass· January 2025

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Development, Validation, and Clinical Utility of a Six-gene Signature to Predict Aggressive Prostate Cancer.
Agnieszka Krzyzanowska, Stephen Barron, Debra F Higgins, Tony Loughman, Amanda O'Neill

Eur Urol Focus· November 2023

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BMP7-induced-Pten inhibits Akt and prevents renal fibrosis.
Debra F Higgins, Leah M Ewart, Enda Masterson, Sadhbh Tennant, Gleb Grebnev

Biochim Biophys Acta Mol Basis Dis· December 2017

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Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.
Hayley Beaton, Darrell Andrews, Martin Parsons, Mary Murphy, Andrew Gaffney, Debra F Higgins

Am J Physiol Renal Physiol· July 2016

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Hypoxia promotes production of neural crest cells in the embryonic head.
Deirdre Scully, Eleanor Keane, Emily Batt, Priyadarssini Karunakaran, Debra F Higgins

Development· May 2016

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Epigenetic unsilencing reverses renal fibrosis.
Debra F Higgins, Madeline Murphy

J Am Soc Nephrol· May 2014

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IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses.
James B Corcoran, Sarah McCarthy, Brenda Griffin, Andrew Gaffney, Una Bhreathnach, Debra F Higgins

Biochim Biophys Acta· August 2013

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Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1.
Eoin P Brennan, Karen A Nolan, Emma Börgeson, Oisín S Gough, Caitríona M McEvoy, Debra F Higgins

J Am Soc Nephrol· March 2013

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Lipoxin A4 attenuates adipose inflammation.
Emma Börgeson, Fiona C McGillicuddy, Karen A Harford, Niamh Corrigan, Debra F Higgins

FASEB J· October 2012

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Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.
Emma Börgeson, Neil G Docherty, Madeline Murphy, Karen Rodgers, Aidan Ryan, Debra F Higgins

FASEB J· September 2011

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Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
Kuniko Kimura, Masayuki Iwano, Debra F Higgins, Yukinari Yamaguchi, Kimihiko Nakatani

Am J Physiol Renal Physiol· October 2008

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Hypoxia-inducible factor signaling in the development of tissue fibrosis.
Debra F Higgins, Kuniko Kimura, Masayuki Iwano, Volker H Haase

Cell Cycle· May 2008

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Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.
Debra F Higgins, Kuniko Kimura, Wanja M Bernhardt, Nikita Shrimanker, Yasuhiro Akai

J Clin Invest· December 2007

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Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.
Erinn B Rankin, Debra F Higgins, Jacqueline A Walisser, Randall S Johnson, Christopher A Bradfield

Mol Cell Biol· April 2005

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Hypoxic induction of Ctgf is directly mediated by Hif-1.
Debra F Higgins, Mangatt P Biju, Yasuhiro Akai, Anton Wutz, Randall S Johnson

Am J Physiol Renal Physiol· December 2004

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DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition.
Debra F Higgins, David W P Lappin, Niamh E Kieran, Hans J Anders, Ronald W G Watson

Kidney Int· December 2003

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Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog.
Niamh E Kieran, Peter P Doran, Susan B Connolly, Marie-Claire Greenan, Debra F Higgins

Kidney Int· August 2003

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