Publications by authors named "Debra Laskin"

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Lung injury, oxidative stress and impaired functioning in a model of prolonged ozone exposure in female mice are associated with macrophage proinflammatory and profibrotic activation and altered bioenergetics.
Vasanthi R Sunil, Kinal N Vayas, Jared Radbel, Ley Cody Smith, Jaclynn Meshanni, Jeffrey D Laskin, Debra L Laskin

Toxicol Sci· December 2025

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Inhalation of titanium dioxide nanoparticles during gestation alters placental bioenergetics in a sex-related manner in rats.
Talia Seymore, Changjiang Guo, Alyssa Bellomo, Julia Herbert, Debra Laskin

Placenta· August 2025

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Inhaled ozone induces distinct alterations in pulmonary function in models of acute and episodic exposure in female mice.
Jordan M Lee, Jaclynn A Meshanni, Kinal N Vayas, Vasanthi R Sunil, Jared Radbel, Jeffrey D Laskin, Debra L Laskin

Toxicol Sci· March 2025

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Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation.
Ley Cody Smith, Elena Abramova, Kinal Vayas, Jessica Rodriguez, Benjamin Gelfand-Titiyevksiy, Jeffrey D Laskin, Debra L Laskin

Toxicol Sci· September 2024

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Protocol for detecting nitrative stress in biological lipid membranes in murine cells and tissues.
Tushar Aggarwal, Alyssa Bellomo, Emily R Stevenson, Julia Herbert, Debra L Laskin

STAR Protoc· September 2024

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Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of nonpneumonic endotoxemia.
Jared Radbel, Jaclynn A Meshanni, Kinal N Vayas, Oahn Le-Hoang, Elena Abramova, Jeffrey D Laskin, Debra L Laskin

Toxicol Sci· August 2024

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Repurposing FDA-approved drugs to treat chemical weapon toxicities: Interactive case studies for trainees.
Lauren M Aleksunes, Joshua P Gray, Jaclynn Meshanni, Jeffrey D Laskin, Debra L Laskin

Pharmacol Res Perspect· August 2024

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Interplay among Oxidative Stress, Autophagy, and the Endocannabinoid System in Neurodegenerative Diseases: Role of the Nrf2- p62/SQSTM1 Pathway and Nutraceutical Activation.
Federica Armeli, Beatrice Mengoni, Debra L Laskin, Rita Businaro

Curr Issues Mol Biol· July 2024

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Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices.
Alyssa Bellomo, Julia Herbert, Melissa J Kudlak, Jeffrey D Laskin, Andrew J Gow, Debra L Laskin

Toxicol Appl Pharmacol· May 2024

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Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard.
Rama Malaviya, Jaclynn A Meshanni, Vasanthi R Sunil, Alessandro Venosa, Changjiang Guo, Jeffrey D Laskin, Debra L Laskin

Toxicol Appl Pharmacol· April 2024

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Suppression of Lung Oxidative Stress, Inflammation, and Fibrosis following Nitrogen Mustard Exposure by the Selective Farnesoid X Receptor Agonist Obeticholic Acid.
Jaclynn A Meshanni, Jordan M Lee, Kinal N Vayas, Rachel Sun, Chenghui Jiang, Jeffrey D Laskin, Debra L Laskin

J Pharmacol Exp Ther· January 2024

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Direct assessment of nitrative stress in lipid environments: Applications of a designer lipid-based biosensor for peroxynitrite.
Bryan Gutierrez, Tushar Aggarwal, Huseyin Erguven, M Rhia L Stone, Changjiang Guo, Debra L Laskin

iScience· December 2023

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Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radiation.
Rama Malaviya, Jeffrey D Laskin, Rita Businaro, Debra L Laskin

Disaster Med Public Health Prep· October 2023

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Skin Models Used to Define Mechanisms of Action of Sulfur Mustard.
Jeffrey D Laskin, Kevin Ozkuyumcu, Peihong Zhou, Claire R Croutch, Diane E Heck, Debra L Laskin

Disaster Med Public Health Prep· October 2023

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Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure.
Ley Cody Smith, Andrew J Gow, Elena Abramova, Kinal Vayas, Changjiang Guo, Jeffrey D Laskin, Debra L Laskin

Toxicol Sci· June 2023

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Resolution of inflammation in xenobiotic-induced mucosal injury and chronic disease.
Kymberly M Gowdy, Debra L Laskin

Toxicol Appl Pharmacol· May 2023

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Menthol flavoring in e-cigarette condensate causes pulmonary dysfunction and cytotoxicity in precision cut lung slices.
Julia Herbert, Jacklyn S Kelty, Jeffrey D Laskin, Debra L Laskin, Andrew J Gow

Am J Physiol Lung Cell Mol Physiol· March 2023

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Novel method to assess resident alveolar macrophage efferocytosis of apoptotic neutrophils by flow cytometry.
Jared Radbel, Jaclynn A Meshanni, Carol R Gardner, Oanh Le-Hoang, Jessica Cervelli, Jeffrey D Laskin, Debra L Laskin

Toxicol Appl Pharmacol· February 2023

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Lung injury and oxidative stress induced by inhaled chlorine in mice is associated with proinflammatory activation of macrophages and altered bioenergetics.
Rama Malaviya, Carol R Gardner, Raymond C Rancourt, Ley Cody Smith, Elena V Abramova, Jeffrey D Laskin, Debra L Laskin

Toxicol Appl Pharmacol· February 2023

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Impaired energy metabolism and altered functional activity of alveolar type II epithelial cells following exposure of rats to nitrogen mustard.
Vasanthi R Sunil, Kinal N Vayas, Jared Radbel, Elena Abramova, Andrew Gow, Jeffrey D Laskin, Debra L Laskin

Toxicol Appl Pharmacol· December 2022

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Regulation of macrophage activation by S-Nitrosothiols following ozone-induced lung injury.
Sheryse Taylor, Alexa Murray, Mary Francis, Elena Abramova, Changjiang Guo, Debra L Laskin

Toxicol Appl Pharmacol· December 2022

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Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard exposure.
Alexa Murray, Tanvi Banota, Grace L Guo, Ley Cody Smith, Jaclynn A Meshanni, Jeffrey D Laskin, Debra L Laskin

Toxicol Appl Pharmacol· November 2022

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Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix.
Laurie B Joseph, Marion K Gordon, Peihong Zhou, Rita A Hahn, Hamdi Lababidi, Debra L Laskin, Jeffrey D Laskin

Exp Mol Pathol· October 2022

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Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes.
Yi-Hua Jan, Diane E Heck, Yunqi An, Debra L Laskin, Jeffrey D Laskin

Chem Res Toxicol· April 2022

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