Publications by authors named "Debra Search"

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Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.
Ricardo A García, John A Lupisella, Bruce R Ito, Mei-Yin Hsu, Gayani Fernando, Debra J Search

JACC Basic Transl Sci· August 2021

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Self-Assembling Cyclic d,l-α-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents.
Yannan Zhao, Luke J Leman, Debra J Search, Ricardo A Garcia, David A Gordon

ACS Cent Sci· June 2017

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Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.
Yan Shi, Jun Li, Lawrence J Kennedy, Shiwei Tao, Andrés S Hernández, Debra Search

ACS Med Chem Lett· June 2016

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P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development.
Ricardo A Garcia, Mujing Yan, Debra Search, Rongan Zhang, Nancy L Carson

PLoS One· June 2015

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11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice.
Ricardo A García, Debra J Search, John A Lupisella, Jacek Ostrowski, Bo Guan

PLoS One· July 2013

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Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.
Xiang-Yang Ye, Stephanie Chen, Hao Zhang, Kenneth T Locke, Kevin O'Malley, Debra Search

Bioorg Med Chem Lett· May 2010

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Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
Jun Li, Lawrence J Kennedy, Yan Shi, Shiwei Tao, Xiang-Yang Ye, Debra Search

J Med Chem· April 2010

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Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.
Ranjan Mukherjee, Kenneth T Locke, Bowman Miao, Daniel Meyers, Hossain Monshizadegan, Debra Search

J Pharmacol Exp Ther· December 2008

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(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.
Saleem Ahmad, Cort S Madsen, Philip D Stein, Evan Janovitz, Christine Huang, Debra Search

J Med Chem· May 2008

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The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.
Cort S Madsen, Evan Janovitz, Rongan Zhang, Van Nguyen-Tran, Carol S Ryan, Debra Search

J Pharmacol Exp Ther· February 2008

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