Publications by authors named "Dechen Lin"

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Unmasking cancer's hidden nerve route with patient-derived organoids.
Kevin M Waters, Akil Merchant, De-Chen Lin

Cell Stem Cell· October 2025

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A high-power spatial, single-cell view of pericytes in esophageal cancer metastasis.
Uttam K Sinha, Young Min Park, De-Chen Lin

Nat Genet· October 2025

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Precision Epigenetic Reprogramming: CoREST Inhibition Sensitizes STK11-Mutant Tumors to Immune Checkpoint Blockade Therapy.
De-Chen Lin, Keyue Shen

Cancer Res· October 2025

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Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma.
Jung Hyun Um, Yueyuan Zheng, Qiong Mao, Chehyun Nam, Hua Zhao, De-Chen Lin

Cancer Res· July 2025

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ETS1 Orchestrates a Hybrid EMT Program Driving in vivo Metastasis and Immune Evasion.
Benjamin Ziman, Talia A Wenger, Chehyun Nam, Qian Yang, Daniel Arnaudov, De-Chen Lin

bioRxiv· July 2025

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The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer.
Chehyun Nam, Guowei Huang, Yueyuan Zheng, Hua Zhao, Yuhao Pan, De-Chen Lin

J Exp Med· April 2025

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Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis.
Yuan Liang, Mengni Liu, Bingyuan Liu, Benjamin Ziman, Guanjie Peng, De-Chen Lin

Epigenetics Chromatin· January 2025

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Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities.
Hua Zhao, Young Min Park, Yueyuan Zheng, Qiong Mao, Casey Collet, Luda Lin, De-Chen Lin

bioRxiv· January 2025

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Mechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis: a mini review.
Ryan S Chung, Stephanie Wong, Dechen Lin, Niels C Kokot, Uttam K Sinha

Front Oncol· August 2024

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Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma.
Jung Hyun Um, Yueyuan Zheng, Qiong Mao, Chehyun Nam, Hua Zhao, De-Chen Lin

bioRxiv· July 2024

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Patient-derived tumor organoids to model drug response in gastric cancer.
Anette Vistoso Monreal, Hua Zhao, Parish P Sedghizadeh, De-Chen Lin

Cell Rep Med· July 2024

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A druggable cascade links methionine metabolism to epigenomic reprogramming in squamous cell carcinoma.
Chehyun Nam, Li-Yan Li, Qian Yang, Benjamin Ziman, Hua Zhao, De-Chen Lin

Proc Natl Acad Sci U S A· June 2024

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Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells.
Masaharu Hazawa, Dini Kurnia Ikliptikawati, Yuki Iwashima, De-Chen Lin, Yuan Jiang

Cell Chem Biol· April 2024

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Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer.
Yuan Jiang, Yueyuan Zheng, Yuan-Wei Zhang, Shuai Kong, Jinxiu Dong, De-Chen Lin

Nat Commun· March 2024

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Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma.
Benjamin Ziman, Qian Yang, Yueyuan Zheng, Megha Sheth, Chehyun Nam, De-Chen Lin

Cell Death Dis· February 2024

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Establishing mouse and human oral esophageal organoids to investigate the tumor immune response.
Yuan Jiang, Hua Zhao, Shuai Kong, Dan Zhou, Jinxiu Dong, De-Chen Lin

Dis Model Mech· January 2024

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Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics.
Young Min Park, De-Chen Lin

Nat Commun· November 2023

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ARID1A Deficiency Regulates Anti-Tumor Immune Response in Esophageal Adenocarcinoma.
Le Zhang, Yueyuan Zheng, Wenwen Chien, Benjamin Ziman, Sandrine Billet, De-Chen Lin

Cancers (Basel)· November 2023

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Comparative impact of grade on mortality across salivary cancers: A novel, unifying staging system.
Allen S Ho, Michael Luu, Bonnie L Balzer, Katri Aro, Julie K Jang, De-Chen Lin

Head Neck· August 2023

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Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation.
Yueyuan Zheng, Benjamin Ziman, Allen S Ho, Uttam K Sinha, Li-Yan Xu, De-Chen Lin

Genome Biol· August 2023

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A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy.
Uttam K Sinha, De-Chen Lin

Theranostics· April 2023

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Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR.
Wenwen Chien, Jeffrey W Tyner, Sigal Gery, Yueyuan Zheng, Li-Yan Li, De-Chen Lin

J Ovarian Res· April 2023

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Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy.
Xue-Bin Ran, Ling-Wen Ding, Qiao-Yang Sun, Henry Yang, Jonathan W Said, Ling-Zhi Wang, De-Chen Lin

Cancer Res· March 2023

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Large-scale genomic analyses reveal alterations and mechanisms underlying clonal evolution and immune evasion in esophageal cancer.
De-Chen Lin

Nat Commun· February 2023

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Single-cell genomics identifies immune response to neoadjuvant chemoradiotherapy.
Uttam K Sinha, W Martin Kast, De-Chen Lin

EBioMedicine· December 2022

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