Publications by authors named "Declan F McCole"

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The rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis.
Pritha Chatterjee, Vinicius Canale, Stephanie J King, Ali Shawki, Hillmin Lei, Declan F McCole

Gut Microbes· December 2025

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Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses.
Pritha Chatterjee, Marianne R Spalinger, Charly Acevedo, Alina N Santos, Casey M Gries, Declan F McCole

Gut Microbes· December 2025

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Brewing a Cure: Engineering Yeast to Reduce Inflammation-Driven Tumors.
Declan F McCole

Dig Dis Sci· November 2025

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Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice.
Meli'sa S Crawford, Arzu Ulu, Briana M Ramirez, Alina N Santos, Pritha Chatterjee, Declan F McCole

J Appl Toxicol· September 2025

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Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene.
Marianne R Spalinger, Golshid Sanati, Pritha Chatterjee, Rong Hai, Jiang Li, Declan F McCole

Cell Mol Gastroenterol Hepatol· April 2025

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Regulates Iron Handling Protein Expression in Inflammatory Bowel Disease Patients and Prevents Iron Deficiency in Mice.
Hillmin Lei, Ali Shawki, Alina N Santos, Vinicius Canale, Salomon Manz, Declan F McCole

Int J Mol Sci· April 2025

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Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses.
Pritha Chatterjee, Marianne R Spalinger, Charly Acevedo, Casey M Gries, Salomon M Manz, Declan F McCole

bioRxiv· September 2024

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The JAK inhibitor, Tofacitinib, Corrects the Overexpression of CEACAM6 and Limits Susceptibility to AIEC Caused by Reduced Activity of the IBD Associated Gene, .
Pritha Chatterjee, Vinicius Canale, Stephanie J King, Ali Shawki, Hillmin Lei, Declan F McCole

medRxiv· September 2024

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Respiratory exposure to agricultural dust extract promotes increased intestinal expression, gut barrier dysfunction, and endotoxemia in mice.
Meli'sa S Crawford, Arzu Ulu, Briana M Ramirez, Alina N Santos, Pritha Chatterjee, Declan F McCole

Am J Physiol Gastrointest Liver Physiol· January 2024

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Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice.
Poonamjot Deol, Paul Ruegger, Geoffrey D Logan, Ali Shawki, Jiang Li, Declan F McCole

Gut Microbes· July 2023

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PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice.
Vinicius Canale, Marianne R Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Declan F McCole

Cell Mol Gastroenterol Hepatol· June 2023

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The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn's Disease but Not Ulcerative Colitis Patients.
Young Su Park, Sang Bum Kang, Ronald R Marchelletta, Harrison M Penrose, Roos Ruiter-Visser, Declan F McCole

Pharmaceutics· March 2023

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PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection.
Marianne R Spalinger, Vinicius Canale, Anica Becerra, Ali Shawki, Meli'sa Crawford, Declan F McCole

JCI Insight· February 2023

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Finding a mate for MLCK: improving the potential for therapeutic targeting of gut permeability.
Declan F McCole

Gut· July 2022

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Autoimmune susceptibility gene is required for clearance of adherent-invasive by integrating bacterial uptake and lysosomal defence.
Marianne Rebecca Spalinger, Ali Shawki, Pritha Chatterjee, Vinicius Canale, Alina Santos, Declan F McCole

Gut· January 2022

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Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Marianne R Spalinger, Meli'sa Crawford, Sarah D Bobardt, Jiang Li, Anica Sayoc-Becerra, Declan F McCole

Mucosal Immunol· January 2022

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Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue and cognitive impairment.
Elena V Kozlova, Bruno Carabelli, Anthony E Bishay, Rui Liu, Maximillian E Denys, Declan F McCole

Life Sci· January 2022

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ZOning in on Novel Roles for Zonula Occludens Proteins in Epithelial Repair.
Declan F Mccole

Gastroenterology· December 2021

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T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.
Ronald R Marchelletta, Moorthy Krishnan, Marianne R Spalinger, Taylaur W Placone, Rocio Alvarez, Declan F McCole

J Clin Invest· September 2021

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JAK-STAT Pathway Regulation of Intestinal Permeability: Pathogenic Roles and Therapeutic Opportunities in Inflammatory Bowel Disease.
Hillmin Lei, Meli'sa S Crawford, Declan F McCole

Pharmaceuticals (Basel)· August 2021

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Every breath you take: Impacts of environmental dust exposure on intestinal barrier function-from the gut-lung axis to COVID-19.
Meli'sa S Crawford, Tara M Nordgren, Declan F McCole

Am J Physiol Gastrointest Liver Physiol· April 2021

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The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions.
Marianne R Spalinger, Anica Sayoc-Becerra, Christ Ordookhanian, Vinicius Canale, Alina N Santos, Declan F McCole

J Crohns Colitis· March 2021

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Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK.
June Guo, Troy J Pereira, Yusaku Mori, Marel Gonzalez Medina, Danna M Breen, Declan F McCole

J Vasc Res· January 2021

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Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells.
Marianne R Spalinger, Rong Hai, Jiang Li, Alina N Santos, Tara M Nordgren, Declan F McCole

bioRxiv· December 2020

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PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.
Marianne R Spalinger, Anica Sayoc-Becerra, Alina N Santos, Ali Shawki, Vinicius Canale, Declan F McCole

Gastroenterology· November 2020

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