Publications by authors named "Deepak A Deshpande"

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Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases.
Sushrut D Shah, Deepak A Deshpande

Am J Respir Cell Mol Biol· October 2025

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Spatiotemporal calcium signaling patterns underlying opposing effects of histamine and TAS2R agonists in airway smooth muscle.
Stanley Conaway, Joshua Richard, Deepak A Deshpande

Am J Physiol Lung Cell Mol Physiol· July 2025

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Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle.
Dominic R Villalba, Arun K Jannu, Elham Javed, Isha Dandekar, Ruping Wang, Deepak A Deshpande

Respir Res· May 2025

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A-Kinase-Anchoring Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle.
Elham Javed, Ajay P Nayak, Arun K Jannu, Aaron H Cohen, Isabella Dewes, Deepak A Deshpande

Am J Respir Cell Mol Biol· February 2025

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CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1.
Soner Dogan, Timothy F Walseth, Bilge Guvenc Tuna, Eda Uçar, Mathur S Kannan, Deepak A Deshpande

IUBMB Life· December 2024

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Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease.
Megumi Shigematsu, Takuya Kawamura, Deepak A Deshpande, Yohei Kirino

Mol Ther Nucleic Acids· September 2024

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Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma.
Miguel A Hernandez-Lara, Joshua Richard, Deepak A Deshpande

Am J Physiol Lung Cell Mol Physiol· July 2024

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Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle.
Stanley Conaway, Weiliang Huang, Miguel A Hernandez-Lara, Maureen A Kane, Raymond B Penn, Deepak A Deshpande

FASEB J· July 2024

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Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease.
Megumi Shigematsu, Takuya Kawamura, Deepak A Deshpande, Yohei Kirino

bioRxiv· June 2024

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Superoxide Anions Inhibit Intracellular Calcium Response in Porcine Airway Smooth Muscle Cells.
Ramesh Krishnan, Mathur S Kannan, Deepak A Deshpande

AJP Rep· April 2024

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Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca Signaling in Airway Smooth Muscle.
Deepak A Deshpande, Raymond B Penn

Am J Respir Cell Mol Biol· December 2023

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Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation.
Brenal K Singh, Yuichi Yokoyama, Yukinori Tanaka, Dorottya Laczkó, Deepak A Deshpande

Cell Immunol· December 2023

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Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma.
Santhoshi V Akkenepally, Dan J K Yombo, Sanjana Yerubandi, Geereddy Bhanuprakash Reddy, Deepak A Deshpande

Nat Commun· December 2023

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Proteomics-Based Approach for Detailing the Allergenic Profile of Cannabis Chemotypes.
Cali Loblundo, Jenna Severa, Gabrielle A Peruggia, Kristina Reid Black, Suman Chandra, Deepak A Deshpande

Int J Mol Sci· September 2023

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Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation.
Miguel A Hernandez-Lara, Santosh Kumar Yadav, Stanley Conaway, Sushrut D Shah, Raymond B Penn, Deepak A Deshpande

Respir Res· June 2023

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Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice.
Sushrut D Shah, Ajay P Nayak, Pawan Sharma, Dominic R Villalba, Sankar Addya, Deepak A Deshpande

Am J Respir Cell Mol Biol· January 2023

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In silico identification of a β-adrenoceptor allosteric site that selectively augments canonical βAR-Gs signaling and function.
Sushrut D Shah, Christoffer Lind, Francesco De Pascali, Raymond B Penn, Alexander D MacKerell, Deepak A Deshpande

Proc Natl Acad Sci U S A· December 2022

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PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells.
Eric Tompkins, Bogdana Mimic, Karina Cuevas-Mora, Hannah Schorsch, Sushrut D Shah, Deepak A Deshpande

Am J Respir Cell Mol Biol· November 2022

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A cryptic mode of GPCR regulation revealed.
Deepak A Deshpande, Raymond B Penn

Trends Mol Med· November 2022

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Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma.
Miguel Angel Hernandez-Lara, Santosh K Yadav, Sushrut D Shah, Mariko Okumura, Yuichi Yokoyama, Deepak A Deshpande

Int J Mol Sci· October 2022

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Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase.
Santosh K Yadav, Pawan Sharma, Sushrut D Shah, Reynold A Panettieri, Taku Kambayashi, Deepak A Deshpande

J Cell Physiol· January 2022

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Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.
Pawan Sharma, Santosh K Yadav, Sushrut D Shah, Elham Javed, John M Lim, Deepak A Deshpande

Am J Respir Cell Mol Biol· December 2021

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OGR1-dependent regulation of the allergen-induced asthma phenotype.
Ajay P Nayak, Deepak A Deshpande, Sushrut D Shah, Dominic R Villalba, Roslyn Yi

Am J Physiol Lung Cell Mol Physiol· December 2021

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Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma.
Amy E Defnet, Sushrut D Shah, Weiliang Huang, Paul Shapiro, Deepak A Deshpande

FASEB J· December 2021

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Nur77 Attenuates Inflammasome Activation by Inhibiting Caspase-1 Expression in Pulmonary Vascular Endothelial Cells.
Ru Ding, Xiaobo Sun, Bing Yi, Wennan Liu, Kyosuke Kazama, Deepak A Deshpande

Am J Respir Cell Mol Biol· September 2021

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