Publications by authors named "Defen Lu"

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Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation.
Yuchao Yang, Yueyue Liu, Xue Ma, Xuan Zhao, Jian Cao, Defen Lu

mBio· September 2025

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cGAS-STING: mechanisms and therapeutic opportunities.
Mengyuan Zhang, Changxin Wu, Defen Lu, Xing Wang, Guijun Shang

Sci China Life Sci· May 2025

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A conserved ion channel function of STING mediates noncanonical autophagy and cell death.
Jinrui Xun, Zhichao Zhang, Bo Lv, Defen Lu, Haoxiang Yang

EMBO Rep· February 2024

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The structure of the RBD-E77 Fab complex reveals neutralization and immune escape of SARS-CoV-2.
Zhichao Zhang, Xiaoxiong Li, Ying Xue, Bo Yang, Yuanyuan Jia, Defen Lu

Acta Crystallogr D Struct Biol· August 2023

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The mechanism of STING autoinhibition and activation.
Sheng Liu, Bo Yang, Yingxiang Hou, Kaige Cui, Xiaozhu Yang, Defen Lu

Mol Cell· May 2023

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Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold.
Shun Liu, Hua Chen, Yan Yin, Defen Lu, Guoming Gao

Sci Adv· April 2023

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Activation of STING Based on Its Structural Features.
Behzad Hussain, Yufeng Xie, Uzma Jabeen, Defen Lu, Bo Yang

Front Immunol· August 2022

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Activation of STING by targeting a pocket in the transmembrane domain.
Defen Lu, Guijun Shang, Jie Li, Yong Lu, Xiao-Chen Bai

Nature· April 2022

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Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.
Defen Lu, Guijun Shang, Xiaojing He, Xiao-Chen Bai, Xuewu Zhang

Nat Commun· May 2021

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Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Hua Chen, Defen Lu, Guijun Shang, Guoming Gao, Xuewu Zhang

Structure· August 2020

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Crystal structures of porcine STING-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
Xiaoyan Cong, Zenglin Yuan, Yijun Du, Bo Wu, Defen Lu

J Biol Chem· July 2019

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Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.
Guijun Shang, Chad A Brautigam, Rui Chen, Defen Lu, Jesús Torres-Vázquez

Elife· May 2017

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The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa.
Defen Lu, Youshi Zheng, Naishun Liao, Ling Wei, Bo Xu

Acta Crystallogr D Biol Crystallogr· December 2014

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Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates.
Deyu Zhu, Lijun Wang, Guijun Shang, Xue Liu, Jing Zhu, Defen Lu

Mol Cell· September 2014

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Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism.
Defen Lu, Guijun Shang, Heqiao Zhang, Qian Yu, Xiaoyan Cong

Mol Microbiol· June 2014

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X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling.
Fengjuan He, Defen Lu, Baichun Jiang, Yan Wang, Qiao Liu

Biochim Biophys Acta· May 2013

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Expression, purification and preliminary crystallographic analysis of the T6SS effector protein Tse3 from Pseudomonas aeruginosa.
Defen Lu, Guijun Shang, Qian Yu, Heqiao Zhang, Yanyu Zhao

Acta Crystallogr Sect F Struct Biol Cryst Commun· May 2013

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Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function.
Guijun Shang, Xiuhua Liu, Defen Lu, Junbing Zhang, Ning Li

Biochem J· December 2012

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Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state.
Wei Cheng, Kun Yin, Defen Lu, Bingqing Li, Deyu Zhu

PLoS Pathog· July 2012

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Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.
Guijun Shang, Deyu Zhu, Ning Li, Junbing Zhang, Chunyuan Zhu, Defen Lu

Nat Struct Mol Biol· June 2012

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Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation.
Xi Li, Defen Lu, Fengjuan He, Haibin Zhou, Qiao Liu

J Biol Chem· September 2011

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Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.
Yongxin Zou, Jun Mi, Jinpeng Cui, Defen Lu, Xiyu Zhang

J Biol Chem· November 2009

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