Publications by authors named "Dehu Dou"

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Pharmacokinetics, Biodistribution, Immunogenicity, and Model-Informed-Based PK/PD Model of a Next-Generation Advanced Novel Gene Therapy for Hemophilia.
Dehu Dou, Jing Lu, Peixin Sangchen, Chaorui Guo, Deli Li

Mol Pharm· October 2025

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Key Challenges and Optimization Practices for Non-clinical Evaluation of AAV based Gene Therapy for Central Nervous System Disease.
Dehu Dou, Jing Lu, Xijing Chen, Xuefeng Zhang

Pharm Res· October 2025

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Preclinical Evaluation of AAV8-R338L Gene Therapy for Hemophilia: Efficacy, Pharmacokinetics, Distribution, Excretion and Toxicity in Mouse Models and Non-human Primates.
Dehu Dou, Jing Lu, Deli Li, Fengxia He, Xi Zhu

Pharm Res· October 2025

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Off-target effects of oligonucleotides and approaches of preclinical assessments.
Haiwen Ruan, Dehu Dou, Jing Lu, Xia Xiao, Xinjiang Gong

SLAS Discov· September 2025

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Nonclinical absorption, distribution, metabolism, excretion and biomarkers properties of a modified N-acetylgalactosamine-conjugated small-interfering RNA for hypercholesteremia.
Dehu Dou, Jing Lu, Ali Fan, Xijing Chen

Drug Metab Dispos· August 2025

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Enhanced pre- and postnatal developmental toxicity (ePPND) study in non-human primates: Necessity, strategic approaches, and critical considerations.
Jing Lu, Dehu Dou, Yawen Wang, Jiaao Shu, Zhiqi Lei

Regul Toxicol Pharmacol· June 2025

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Global regulatory considerations and practices for tumorigenicity evaluation of cell-based therapy.
Dehu Dou, Jing Lu, Jinhui Dou, Yan Huo, Xinjiang Gong

Regul Toxicol Pharmacol· February 2025

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