Publications by authors named "Demeng Sun"

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Synthesis and evaluation of 5, 6-dihydro-8-isoquinolino[1, 2-]quinazolin-8-one derivatives as novel non-lipogenic ABCA1 up-regulators with inhibitory effects on macrophage-derived foam cell formation.
Changhuan Yang, Lin Chen, Yanmei Jiang, Demeng Sun, Yun Hu

J Enzyme Inhib Med Chem· December 2025

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Oligomerization is Required for Channel Formation of MctB and for Copper Resistance of Mycobacterium tuberculosis.
Axel Siroy, Demeng Sun, Avraneel Paul, Jennifer L Rowland, Lisa M Jones

J Biol Chem· December 2025

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Cryo-EM Structures Reveal Nonmirror-Image Binding of L- and D-Peptide Enantiomers at α7 Nicotinic Acetylcholine Receptor.
Ziyan Xu, Xiuxiu Cao, Tianqi Liu, Haopeng Chen, Sanling Liu, Demeng Sun

Chembiochem· November 2025

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Solution NMR Analysis Reveals Synergistic β-Arrestin1 Activation by Chemically Synthesized Phosphopeptides of a C-Terminal Tail and ICL3 of NTSR1.
Zelin Li, Yi Zhang, Jun Liang, Fengyu Jia, Jiacai Song, Demeng Sun

ACS Chem Biol· July 2025

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Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood-Brain Barrier and Treatment of Glioblastoma Multiforme.
Haiyang Tong, Zesen Ma, Jin Yu, Dongsheng Li, Qingjun Zhu, Demeng Sun

ACS Chem Biol· April 2025

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Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator.
Demeng Sun, Xiang Li, Qingning Yuan, Yuanxia Wang, Pan Shi, Wenjing Sun

Cell Res· April 2025

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1, 4-benzodioxan-substituted Thienyl chalcone derivatives as novel reversible inhibitors of human monoamine oxidase B with anti-neuroinflammatory activity.
Demeng Sun, Mengxue Mu, Yanmei Jiang, Bo Wang, Zuo Kong

Sci Rep· March 2025

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Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action.
Yang Li, Xuteng Lu, Xufeng Cheng, Keyu Xia, Junyan Hu, Demeng Sun

Nat Commun· March 2025

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Benzodioxane Carboxamide Derivatives As Novel Monoamine Oxidase B Inhibitors with Antineuroinflammatory Activity.
Demeng Sun, Bo Wang, Yanmei Jiang, Zuo Kong, Mengxue Mu

ACS Med Chem Lett· June 2024

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De Novo Screening and Mirror Image Isomerization of Linear Peptides Targeting α7 Nicotinic Acetylcholine Receptor.
Xiuxiu Cao, Tianqi Liu, Tao Wang, Xudong Wang, Ziyan Xu, Demeng Sun

ACS Chem Biol· March 2024

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Modification of Low-Energy Surfaces Using Bicyclic Peptides Discovered by Phage Display.
Lingxiao Wang, Haodong Li, Xinyan Wang, Xichu Yang, Changlin Tian, Demeng Sun

J Am Chem Soc· August 2023

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Cryo-EM structure reveals a symmetry reduction of the plant outward-rectifier potassium channel SKOR.
Siyu Li, Yuanxia Wang, Chenyang Wang, Yong Zhang, Demeng Sun

Cell Discov· June 2023

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Total stepwise solid-phase synthesis of peptide-oligonucleotide conjugates using side-chain Boc/Bu protecting groups.
Tao Wang, Xiuxiu Cao, Yong Zheng, Chenchen Chen, Li Zhou, Demeng Sun

Chem Commun (Camb)· May 2023

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Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue.
Fan Yang, Huanhuan Zhang, Xianyu Meng, Yingge Li, Yingxin Zhou, Demeng Sun

Cell Res· September 2022

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Author Correction: Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue.
Fan Yang, Huanhuan Zhang, Xianyu Meng, Yingge Li, Yingxin Zhou, Demeng Sun

Cell Res· August 2022

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Parthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV‑2 papain-like protease.
Zhihui Zou, Huizhuang Shan, Demeng Sun, Li Xia, Yulong Shi

Acta Biochim Biophys Sin (Shanghai)· August 2022

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Thioester-Assisted Sortase-A-Mediated Ligation.
Chong Zuo, Ruichao Ding, Xiangwei Wu, Yuanxia Wang, Guo-Chao Chu, Demeng Sun

Angew Chem Int Ed Engl· July 2022

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Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues.
Qing Bo, Fan Yang, Yingge Li, Xianyu Meng, Huanhuan Zhang, Demeng Sun

Cell Discov· May 2022

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Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor β-Adrenergic Receptor with Defined Modification Patterns at the C-Terminus.
Yulei Li, Jie Heng, Demeng Sun, Baochang Zhang, Xin Zhang, Xiaoou Sun

J Am Chem Soc· October 2021

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Structural basis of human α7 nicotinic acetylcholine receptor activation.
Yue Zhao, Sanling Liu, Yingxin Zhou, Mengge Zhang, Haopeng Chen, Demeng Sun

Cell Res· June 2021

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Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca ions and L-tryptophan.
Shenglong Ling, Pan Shi, Sanling Liu, Xianyu Meng, Yingxin Zhou, Wenjing Sun, Demeng Sun

Cell Res· April 2021

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Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B.
Zhuo Kong, Demeng Sun, Yanmei Jiang, Yun Hu

J Enzyme Inhib Med Chem· December 2020

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Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis.
Siyu Li, Fan Yang, Demeng Sun, Yong Zhang, Mengge Zhang

Cell Res· November 2020

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Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Demeng Sun, Sanling Liu, Siyu Li, Mengge Zhang, Fan Yang

Elife· September 2020

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A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET.
Pan Shi, Yanan Zhang, Pei Lv, Wei Fang, Shenglong Ling, Demeng Sun

Chem Commun (Camb)· June 2020

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