Publications by authors named "Demet Arac"

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The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling.
Sumit J Bandekar, Ethan E Dintzner, Katherine Leon, Szymon P Kordon, Tomasz Slezak

Proc Natl Acad Sci U S A· December 2025

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Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development.
Gabriel Carmona-Rosas, Jingxian Li, Jayson J Smith, Wioletta I Nawrocka, Shouqiang Cheng

Nat Struct Mol Biol· September 2025

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The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling.
Sumit J Bandekar, Ethan E Dintzner, Katherine Leon, Szymon P Kordon, Tomasz Slezak

bioRxiv· July 2025

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Structural basis for regulation of CELSR1 by a compact module in its extracellular region.
Sumit J Bandekar, Krassimira Garbett, Szymon P Kordon, Ethan E Dintzner, Jingxian Li

Nat Commun· April 2025

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Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function.
Szymon P Kordon, Kristina Cechova, Sumit J Bandekar, Katherine Leon, Przemysław Dutka

Nat Commun· December 2024

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Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains.
Szymon P Kordon, Kristina Cechova, Sumit J Bandekar, Katherine Leon, Przemysław Dutka

bioRxiv· February 2024

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Structure of the extracellular region of the adhesion GPCR CELSR1 reveals a compact module which regulates G protein-coupling.
Sumit J Bandekar, Krassimira Garbett, Szymon P Kordon, Ethan Dintzner, Tanner Shearer

bioRxiv· January 2024

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The structure of fly Teneurin-m reveals an asymmetric self-assembly that allows expansion into zippers.
Jingxian Li, Sumit J Bandekar, Demet Araç

EMBO Rep· June 2023

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The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.
Duy Lan Huong Bui, Andrew Roach, Jingxian Li, Sumit J Bandekar, Elizabeth Orput

Cell Rep· June 2023

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The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.
Duy Lan Huong Bui, Andrew Roach, Jingxian Li, Sumit J Bandekar, Elizabeth Orput

bioRxiv· April 2023

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Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
Szymon P Kordon, Przemysław Dutka, Justyna M Adamska, Sumit J Bandekar, Katherine Leon

Nat Commun· February 2023

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Specific and direct modulation of the interaction between adhesion GPCR GPR56/ADGRG1 and tissue transglutaminase 2 using synthetic ligands.
Gabriel S Salzman, Shu Zhang, Celia G Fernandez, Demet Araç, Shohei Koide

Sci Rep· October 2020

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Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.
Jingxian Li, Yuan Xie, Shaleeka Cornelius, Xian Jiang, Richard Sando

Nat Commun· May 2020

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Structural basis for adhesion G protein-coupled receptor Gpr126 function.
Katherine Leon, Rebecca L Cunningham, Joshua A Riback, Ezra Feldman, Jingxian Li

Nat Commun· January 2020

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The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
Rory K Morgan, Garret R Anderson, Demet Araç, Gabriela Aust, Nariman Balenga

Ann N Y Acad Sci· November 2019

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Teneurin Structure: Splice Variants of a Bacterial Toxin Homolog Specifies Synaptic Connections.
Demet Araç, Jingxian Li

Front Neurosci· August 2019

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Teneurins and latrophilins: two giants meet at the synapse.
Demet Araç, Jingxian Li

Curr Opin Struct Biol· February 2019

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A Comprehensive Mutagenesis Screen of the Adhesion GPCR Latrophilin-1/ADGRL1.
Olha Nazarko, Amanuel Kibrom, Jana Winkler, Katherine Leon, Hannah Stoveken

iScience· May 2018

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Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Jingxian Li, Moran Shalev-Benami, Richard Sando, Xian Jiang, Amanuel Kibrom

Cell· April 2018

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A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model.
Pavol Skubák, Demet Araç, Matthew W Bowler, Ana R Correia, Andre Hoelz

IUCrJ· March 2018

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-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region.
Gabriel S Salzman, Shu Zhang, Ankit Gupta, Akiko Koide, Shohei Koide

Proc Natl Acad Sci U S A· September 2017

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Understanding the Structural Basis of Adhesion GPCR Functions.
Demet Araç, Norbert Sträter, Elena Seiradake

Handb Exp Pharmacol· June 2017

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Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.
Gabriel S Salzman, Sarah D Ackerman, Chen Ding, Akiko Koide, Katherine Leon

Neuron· September 2016

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International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Jörg Hamann, Gabriela Aust, Demet Araç, Felix B Engel, Caroline Formstone

Pharmacol Rev· October 2015

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Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
Yue C Lu, Olha V Nazarko, Richard Sando, Gabriel S Salzman, Nan-Sheng Li

Structure· September 2015

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