Publications by authors named "Demetres D Leonidas"

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Expression, purification, and biophysical analysis of a part of the C-terminal domain of human hypoxia inducible factor-2α (HIF-2α).
Aikaterini Diseri, George Stravodimos, Aikaterini Argyriou, Georgios A Spyroulias, Demetres D Leonidas

Biochem Biophys Res Commun· December 2024

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Kinetic and Structural Studies of the Plastidial Phosphorylase.
Symeon M Koulas, Efthimios Kyriakis, Anastasia S Tsagkarakou, Demetres D Leonidas

ACS Omega· October 2024

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Evidence for the Quercetin Binding Site of Glycogen Phosphorylase as a Target for Liver-Isoform-Selective Inhibitors against Glioblastoma: Investigation of Flavanols Epigallocatechin Gallate and Epigallocatechin.
Serafeim Alexopoulos, Megan McGawley, Roshini Mathews, Souzana Papakostopoulou, Symeon Koulas, Demetres D Leonidas

J Agric Food Chem· October 2024

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Silver ciprofloxacin (CIPAG): a multitargeted metallodrug in the development of breast cancer therapy.
Christina N Banti, Foteini D Kalousi, Anna-Maria G Psarra, Eleni E Moushi, Demetres D Leonidas

J Biol Inorg Chem· March 2024

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Biochemical and Structural Studies of LjSK1, a GSK3β/SHAGGY-like Kinase, Reveal Its Functional Role.
Theodora G A Solovou, George Stravodimos, Georgios E Papadopoulos, Vassiliki T Skamnaki, Kalliope Papadopoulou, Demetres D Leonidas

J Agric Food Chem· February 2024

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Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models.
Rachel T Mathomes, Symeon M Koulas, Ioannis Tsialtas, George Stravodimos, Philip J Welsby, Demetres D Leonidas

Chem Biol Interact· September 2023

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Strong Binding of -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds.
László Lázár, Anastasia S Tsagkarakou, George Stravodimos, George Kontopidis, Hakon Leffler, Demetres D Leonidas

J Med Chem· September 2023

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Structural and Biochemical Characterization of the Human Angiogenin-Proliferating Cell Nuclear Antigen Interaction.
Olga S E Papaioannou, Aikaterini C Tsika, Magdalini Rovoli, Georgios E Papadopoulos, George Kontopidis, Demetres D Leonidas

Biochemistry· June 2023

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The structure of AgamOBP5 in complex with the natural insect repellents Carvacrol and Thymol: Crystallographic, fluorescence and thermodynamic binding studies.
Panagiota G V Liggri, Katerina E Tsitsanou, Evgenia C V Stamati, Francesca Saitta, Christina E Drakou, Demetres D Leonidas

Int J Biol Macromol· May 2023

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Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN.
Rafailia A A Beta, Athanasios Kyritsis, Veroniki Douka, Eirini Papanastasi, Marianna Rizouli, Demetres D Leonidas

FEBS Open Bio· May 2022

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Glycogen phosphorylase revisited: extending the resolution of the R- and T-state structures of the free enzyme and in complex with allosteric activators.
Demetres D Leonidas, Spyros E Zographos, Katerina E Tsitsanou, Vassiliki T Skamnaki, George Stravodimos

Acta Crystallogr F Struct Biol Commun· September 2021

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Mutagenesis of a Lotus japonicus GSK3β/Shaggy-like kinase reveals functionally conserved regulatory residues.
Theodora G A Solovou, Constantine Garagounis, Efthimios Kyriakis, Charalambos Bobas, Georgios E Papadopoulos, Demetres D Leonidas

Phytochemistry· June 2021

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Nicotinic cholinergic system and COVID-19: evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions.
Nikolaos Alexandris, George Lagoumintzis, Christos T Chasapis, Demetres D Leonidas, Georgios E Papadopoulos

Toxicol Rep· December 2020

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Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Ben A Chetter, Efthimios Kyriakis, Daniel Barr, Aikaterini G Karra, Elisabeth Katsidou, Demetres D Leonidas

Bioorg Chem· September 2020

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Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode.
Christina E Drakou, Chrysavgi Gardeli, Ioannis Tsialtas, Serafeim Alexopoulos, Athanasios Mallouchos, Demetres D Leonidas

J Agric Food Chem· September 2020

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Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications.
Konstantinos Farsalinos, Elias Eliopoulos, Demetres D Leonidas, Georgios E Papadopoulos, Socrates Tzartos

Int J Mol Sci· August 2020

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The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
Efthimios Kyriakis, Aikaterini G Karra, Olga Papaioannou, Theodora Solovou, Vassiliki T Skamnaki, Demetres D Leonidas

Bioorg Med Chem· January 2020

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Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.
Katalin E Szabó, Efthimios Kyriakis, Anna-Maria G Psarra, Aikaterini G Karra, Ádám Sipos, Demetres D Leonidas

J Med Chem· July 2019

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High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl--acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors.
Thomas Fischer, Symeon M Koulas, Anastasia S Tsagkarakou, Efthimios Kyriakis, George A Stravodimos, Demetres D Leonidas

Molecules· April 2019

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Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.
Efthimios Kyriakis, Theodora G A Solovou, Sándor Kun, Katalin Czifrák, Béla Szőcs, Demetres D Leonidas

Bioorg Chem· April 2018

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A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Sándor Kun, Jaida Begum, Efthimios Kyriakis, Evgenia C V Stamati, Thomas A Barkas, Demetres D Leonidas

Eur J Med Chem· March 2018

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Evidence for Novel Action at the Cell-Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, in silico and in vivo Studies.
Demetra S M Chatzileontiadou, Aikaterini C Tsika, Zoi Diamantopoulou, Jean Delbé, Josette Badet, Demetres D Leonidas

ChemMedChem· February 2018

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Potential interference of aluminum chlorohydrate with estrogen receptor signaling in breast cancer cells.
Vyron A Gorgogietas, Ioannis Tsialtas, Natalie Sotiriou, Vasiliki C Laschou, Aikaterini G Karra, Demetres D Leonidas

J Mol Biochem· January 2018

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Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
Éva Bokor, Efthimios Kyriakis, Theodora G A Solovou, Csenge Koppány, Anastassia L Kantsadi, Demetres D Leonidas

J Med Chem· November 2017

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Proteomic Analysis of Human Angiogenin Interactions Reveals Cytoplasmic PCNA as a Putative Binding Partner.
Demetra S M Chatzileontiadou, Martina Samiotaki, Annika N Alexopoulou, Marina Cotsiki, George Panayotou, Demetres D Leonidas

J Proteome Res· October 2017

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