Publications by authors named "Denis Kay"

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Safety, pharmacokinetics, and pharmacodynamics of Gln-1062, a prodrug of galantamine.
Charlotte Bakker, Jasper van der Aart, Ellen P Hart, Erica S Klaassen, Kirsten R Bergmann, Denis G Kay

Alzheimers Dement (N Y)· October 2020

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Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.
Jackalina M Van Kampen, Denis G Kay

PLoS One· October 2017

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Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.
Babykumari P Chitramuthu, Denis G Kay, Andrew Bateman, Hugh P J Bennett

PLoS One· August 2017

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The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease.
Jackalina M Van Kampen, David C Baranowski, Harold A Robertson, Christopher A Shaw, Denis G Kay

PLoS One· June 2016

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First in human study with a prodrug of galantamine: Improved benefit-risk ratio?
Anne C Baakman, Ellen 't Hart, Denis G Kay, Jasper Stevens, Erica S Klaassen

Alzheimers Dement (N Y)· January 2016

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Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease.
Jackalina M Van Kampen, David Baranowski, Denis G Kay

PLoS One· June 2015

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Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease.
Jackalina M Van Kampen, David B Baranowski, Christopher A Shaw, Denis G Kay

Exp Gerontol· February 2014

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Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1.
Babykumari P Chitramuthu, David C Baranowski, Denis G Kay, Andrew Bateman, Hugh Pj Bennett

Mol Neurodegener· October 2010

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Progranulin is expressed within motor neurons and promotes neuronal cell survival.
Cara L Ryan, David C Baranowski, Babykumari P Chitramuthu, Suneil Malik, Zhi Li, Denis G Kay

BMC Neurosci· October 2009

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Overexpression of Notch1 ectodomain in myeloid cells induces vascular malformations through a paracrine pathway.
Xiujie Li, Ezequiel Calvo, Marc Cool, Pavel Chrobak, Denis G Kay

Am J Pathol· January 2007

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Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.
Mathieu Lupien, Anne Diévart, Carlos R Morales, Louis Hermo, Ezequiel Calvo, Denis G Kay

Dev Biol· December 2006

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Structurally distinct ligand-binding or ligand-independent Notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently.
Elena Priceputu, Isabelle Bouallaga, YaoPing Zhang, Xiujie Li, Pavel Chrobak, Denis G Kay

J Immunol· August 2006

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Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.
Patrick Vincent, Elena Priceputu, Denis Kay, Kalle Saksela, Paul Jolicoeur

J Biol Chem· March 2006

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The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice.
Elena Priceputu, Isabelle Rodrigue, Pavel Chrobak, Johanne Poudrier, Tak W Mak, Denis G Kay

J Virol· May 2005

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In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice.
Zaher Hanna, Elena Priceputu, Denis G Kay, Johanne Poudrier, Pavel Chrobak

Virology· October 2004

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CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.
Xiaoduan Weng, Elena Priceputu, Pavel Chrobak, Johanne Poudrier, Denis G Kay

J Virol· May 2004

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Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes.
Paul Jolicoeur, Chunyan Hu, Tak W Mak, Jean-Claude Martinou, Denis G Kay

J Virol· December 2003

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The AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with accumulation of immature CD11bHi dendritic cells.
Johanne Poudrier, Xiaoduan Weng, Denis G Kay, Zaher Hanna, Paul Jolicoeur

J Virol· November 2003

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Oligodendrocyte-specific expression of human immunodeficiency virus type 1 Nef in transgenic mice leads to vacuolar myelopathy and alters oligodendrocyte phenotype in vitro.
Fatiha Radja, Denis G Kay, Steffen Albrecht, Paul Jolicoeur

J Virol· November 2003

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Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 nef in cells of the immune system.
Denis G Kay, Ping Yue, Zaher Hanna, Serge Jothy, Etienne Tremblay

Am J Pathol· July 2002

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Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.
Marie-Chantal Simard, Pavel Chrobak, Denis G Kay, Zaher Hanna, Serge Jothy

J Virol· April 2002

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Mucosal candidiasis in transgenic mice expressing human immunodeficiency virus type 1.
Louis de Repentigny, Francine Aumont, Jean-Sébastien Ripeau, Marie Fiorillo, Denis G Kay

J Infect Dis· April 2002

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