Publications by authors named "Denis Leclerc"

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PapMV nanoparticles: A novel pathway to SARS-CoV-2 protection, distinct from Imidazoquinolines.
Marilène Bolduc, Philippe Saint-Louis, Damien Carignan, Caroline Garneau, Yann Breton, Denis Leclerc

Nanomedicine· December 2025

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Systemic administration of a viral nanoparticle neoadjuvant prevents lung metastasis development through emergency myelopoiesis.
Léa Bourguignon, Roxann Hétu-Arbour, Tania Charpentier, Marilène Bolduc, Denis Leclerc

Oncoimmunology· December 2024

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A rapid procedure to generate stably transfected HEK293 suspension cells for recombinant protein manufacturing: Yield improvements, bioreactor production and downstream processing.
Shantoshini Dash, Omar Farnós, Zeyu Yang, Ayyappasamy Sudalaiyadum Perumal, Julia Puppin Chaves Fulber, Denis Leclerc

Protein Expr Purif· October 2023

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A nanoparticle-based COVID-19 vaccine candidate elicits broad neutralizing antibodies and protects against SARS-CoV-2 infection.
Santa-Mariela Olivera-Ugarte, Marilène Bolduc, Marie-Ève Laliberté-Gagné, Léa-Jeanne Blanchette, Caroline Garneau, Denis Leclerc

Nanomedicine· August 2022

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MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy.
David Possamaï, Laïla-Aïcha Hanafi, Angélique Bellemare-Pelletier, Katia Hamelin, Paméla Thébault, Denis Leclerc

PLoS One· January 2022

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Modulation of Antigen Display on PapMV Nanoparticles Influences Its Immunogenicity.
Marie-Eve Laliberté-Gagné, Marilène Bolduc, Caroline Garneau, Santa-Mariela Olivera-Ugarte, Pierre Savard, Denis Leclerc

Vaccines (Basel)· January 2021

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Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation.
Omar Farnós, Alina Venereo-Sánchez, Xingge Xu, Cindy Chan, Shantoshini Dash, Denis Leclerc

Vaccines (Basel)· November 2020

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A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18-50 Years of Age.
Joanne Langley, Elodie Pastural, Scott Halperin, Shelly McNeil, May ElSherif, Denis Leclerc

Vaccines (Basel)· July 2020

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Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform.
Marie-Ève Laliberté-Gagné, Marilène Bolduc, Ariane Thérien, Caroline Garneau, Philippe Casault, Denis Leclerc

Vaccines (Basel)· June 2019

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The quest for a nanoparticle-based vaccine inducing broad protection to influenza viruses.
Marilène Bolduc, Mariana Baz, Marie-Ève Laliberté-Gagné, Damien Carignan, Caroline Garneau, Denis Leclerc

Nanomedicine· November 2018

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Activation of innate immunity in primary human cells using a plant virus derived nanoparticle TLR7/8 agonist.
Damien Carignan, Sabine Herblot, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Michel Duval, Denis Leclerc

Nanomedicine· October 2018

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Efficacy of a Virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation and Antibody Interference.
Karine Chartrand, Marie-Ève Lebel, Esther Tarrab, Pierre Savard, Denis Leclerc

Front Immunol· January 2018

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A versatile papaya mosaic virus (PapMV) vaccine platform based on sortase-mediated antigen coupling.
Ariane Thérien, Mikaël Bédard, Damien Carignan, Gervais Rioux, Louis Gauthier-Landry, Denis Leclerc

J Nanobiotechnology· July 2017

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Complement Component 3 Regulates IFN-α Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus-like Nanoparticle.
Marie-Ève Lebel, Marie-Pierre Langlois, Jean-François Daudelin, Esther Tarrab, Pierre Savard, Denis Leclerc

J Immunol· January 2017

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Influence of PapMV nanoparticles on the kinetics of the antibody response to flu vaccine.
Gervais Rioux, Damien Carignan, Alexis Russell, Marilène Bolduc, Marie-Ève Laliberté Gagné, Denis Leclerc

J Nanobiotechnology· June 2016

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Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles.
Marie-Ève Lebel, Karine Chartrand, Esther Tarrab, Pierre Savard, Denis Leclerc

Nano Lett· March 2016

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Engineering of the PapMV vaccine platform with a shortened M2e peptide leads to an effective one dose influenza vaccine.
Damien Carignan, Ariane Thérien, Gervais Rioux, Geneviève Paquet, Marie-Ève Laliberté Gagné, Denis Leclerc

Vaccine· December 2015

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Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants.
Marie-Ève Lebel, Karine Chartrand, Denis Leclerc, Alain Lamarre

Vaccines (Basel)· August 2015

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Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.
Laïla-Aïcha Hanafi, Dominique Gauchat, Jessica Godin-Ethier, David Possamaï, Jean-Baptiste Duvignaud, Denis Leclerc

PLoS One· July 2015

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PapMV nanoparticles improve mucosal immune responses to the trivalent inactivated flu vaccine.
Gervais Rioux, Claudia Mathieu, Alexis Russell, Marilène Bolduc, Marie-Eve Laliberté-Gagné, Denis Leclerc

J Nanobiotechnology· May 2014

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A novel M2e based flu vaccine formulation for dogs.
Denis Leclerc, Marie Rivest, Cindy Babin, Constantino López-Macias, Pierre Savard

PLoS One· April 2014

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Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection.
Marie-Ève Lebel, Jean-François Daudelin, Karine Chartrand, Esther Tarrab, Ulrich Kalinke, Denis Leclerc

J Immunol· February 2014

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Induction of innate immunity in lungs with virus-like nanoparticles leads to protection against influenza and Streptococcus pneumoniae challenge.
Claudia Mathieu, Gervais Rioux, Marie-Christine Dumas, Denis Leclerc

Nanomedicine· October 2013

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Engineering of papaya mosaic virus (PapMV) nanoparticles with a CTL epitope derived from influenza NP.
Cindy Babin, Nathalie Majeau, Denis Leclerc

J Nanobiotechnology· April 2013

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Crystal structure of the coat protein of the flexible filamentous papaya mosaic virus.
Shaoqing Yang, Tao Wang, Jen Bohon, Marie-Ève Laliberté Gagné, Marilène Bolduc, Denis Leclerc

J Mol Biol· September 2012

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