Publications by authors named "Denise J Spring"

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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer.
Kyle A LaBella, Wen-Hao Hsu, Jiexi Li, Yutao Qi, Yonghong Liu, Denise J Spring

Dev Cell· June 2024

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Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression.
Wen-Hao Hsu, Kyle A LaBella, Yiyun Lin, Ping Xu, Rumi Lee, Denise J Spring

Cancer Discov· December 2023

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Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer.
Jincheng Han, Jiaqian Xu, Yonghong Liu, Shaoheng Liang, Kyle A LaBella, Denise J Spring

Genes Dev· September 2023

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Histone demethylase KDM5D upregulation drives sex differences in colon cancer.
Jiexi Li, Zhengdao Lan, Wenting Liao, James W Horner, Xueping Xu, Denise J Spring

Nature· July 2023

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Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer.
Pat Gulhati, Aislyn Schalck, Shan Jiang, Xiaoying Shang, Chang-Jiun Wu, Denise J Spring

Nat Cancer· January 2023

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Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.
Rumi Lee, Jiexi Li, Jun Li, Chang-Jiun Wu, Shan Jiang, Denise J Spring

Cancer Discov· July 2022

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AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.
Yohei Yoshihama, Kyle A LaBella, Eiru Kim, Lori Bertolet, Medina Colic, Denise J Spring

Proc Natl Acad Sci U S A· September 2021

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Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Deepavali Chakravarti, Rumi Lee, Asha S Multani, Andrea Santoni, Zachery Keith, Denise J Spring

Proc Natl Acad Sci U S A· July 2021

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Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer.
Di Zhao, Li Cai, Xin Lu, Xin Liang, Jiexi Li, Denise J Spring

Cancer Discov· September 2020

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Telomere dysfunction activates YAP1 to drive tissue inflammation.
Deepavali Chakravarti, Baoli Hu, Xizeng Mao, Asif Rashid, Jiexi Li, Denise J Spring

Nat Commun· September 2020

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Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer.
Pingping Hou, Avnish Kapoor, Qiang Zhang, Jiexi Li, Chang-Jiun Wu, Denise J Spring

Cancer Discov· July 2020

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Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment.
Prasenjit Dey, Jun Li, Jianhua Zhang, Surendra Chaurasiya, Anders Strom, Denise J Spring

Cancer Discov· April 2020

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Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment.
Peiwen Chen, Wen-Hao Hsu, Andrew Chang, Zhi Tan, Zhengdao Lan, Denise J Spring

Cancer Discov· March 2020

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USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.
Pingping Hou, Xingdi Ma, Qiang Zhang, Chang-Jiun Wu, Wenting Liao, Denise J Spring

Genes Dev· October 2019

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Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma.
Peiwen Chen, Di Zhao, Jun Li, Xin Liang, Jiexi Li, Denise J Spring

Cancer Cell· June 2019

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KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Wenting Liao, Michael J Overman, Adam T Boutin, Xiaoying Shang, Di Zhao, Denise J Spring

Cancer Cell· April 2019

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Genetics and biology of prostate cancer.
Guocan Wang, Di Zhao, Denise J Spring, Ronald A DePinho

Genes Dev· September 2018

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PAF promotes stemness and radioresistance of glioma stem cells.
Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Gabriel Sauvé, Christopher A Bristow, Denise J Spring

Proc Natl Acad Sci U S A· October 2017

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Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer.
Xin Lu, James W Horner, Erin Paul, Xiaoying Shang, Patricia Troncoso, Denise J Spring

Nature· May 2017

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Effective combinatorial immunotherapy for castration-resistant prostate cancer.
Xin Lu, James W Horner, Erin Paul, Xiaoying Shang, Patricia Troncoso, Denise J Spring

Nature· March 2017

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Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.
Di Zhao, Xin Lu, Guocan Wang, Zhengdao Lan, Wenting Liao, Denise J Spring

Nature· February 2017

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Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth.
Baoli Hu, Qianghu Wang, Y Alan Wang, Sujun Hua, Charles-Etienne Gabriel Sauvé, Denise J Spring

Cell· November 2016

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Cancer Genomics in Clinical Context.
Lynda Chin, Jennifer A Wargo, Denise J Spring, Hagop Kantarjian, P Andrew Futreal

Trends Cancer· September 2015

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Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury.
Akira Shimamoto, Albert J Chong, Masaki Yada, Shin Shomura, Hiroo Takayama, Denise J Spring

Circulation· July 2006

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Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats.
Jun Lu, Hideto Shimpo, Akira Shimamoto, Albert J Chong, Craig R Hampton, Denise J Spring

J Thorac Cardiovasc Surg· December 2004

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