Publications by authors named "Dennis Discher"

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Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.
Serena Omo-Lamai, Yufei Wang, Manthan N Patel, Aleksa Milosavljevic, Daniel Zuschlag, Dennis Discher

Nat Nanotechnol· September 2025

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Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia.
Lawrence J Dooling, Alişya A Anlaş, Michael P Tobin, Nicholas M Ontko, Tristan Marchena, Dennis E Discher

Proc Natl Acad Sci U S A· July 2025

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Matrix stiffness induces heritable changes in chromosome numbers, consistent with solid tumor heterogeneity.
Alişya A Anlaş, Markus T Sprenger, Mai Wang, Nick Ontko, Steven Phan, Dennis E Discher

bioRxiv· January 2025

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Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia.
Lawrence J Dooling, Alişya A Anlaş, Michael P Tobin, Nicholas M Ontko, Tristan Marchena, Dennis E Discher

bioRxiv· September 2024

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Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG.
Brandon H Hayes, Mai Wang, Hui Zhu, Steven H Phan, Lawrence J Dooling, Dennis E Discher

Elife· May 2024

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Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects.
Serena Omo-Lamai, Yufei Wang, Manthan N Patel, Eno-Obong Essien, Mengwen Shen, Dennis Discher

bioRxiv· April 2024

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Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response.
Brandon H Hayes, Mai Wang, Hui Zhu, Steven H Phan, Lawrence J Dooling, Dennis E Discher

bioRxiv· January 2024

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Genetic heterogeneity in p53-null leukemia increases transiently with spindle assembly checkpoint inhibition and is not rescued by p53.
Mai Wang, Steven Phan, Brandon H Hayes, Dennis E Discher

Chromosoma· January 2024

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Differences in cell shape, motility, and growth reflect chromosomal number variations that can be visualized with live-cell ChReporters.
Michael P Tobin, Charlotte R Pfeifer, Peter Kuangzheng Zhu, Brandon H Hayes, Mai Wang, Dennis E Discher

Mol Biol Cell· December 2023

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Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses.
Lawrence J Dooling, Jason C Andrechak, Brandon H Hayes, Siddhant Kadu, William Zhang, Dennis E Discher

Nat Biomed Eng· September 2023

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Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture.
Irena L Ivanovska, Michael P Tobin, Tianyi Bai, Lawrence J Dooling, Dennis E Discher

J Cell Biol· August 2023

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Titrating CD47 by mismatch CRISPR-interference reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of antitumor IgG.
Brandon H Hayes, Hui Zhu, Jason C Andrechak, Lawrence J Dooling, Dennis E Discher

PNAS Nexus· August 2023

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Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters.
Brandon H Hayes, Peter Kuangzheng Zhu, Mai Wang, Charlotte R Pfeifer, Yuntao Xia, Dennis E Discher

J Cell Sci· June 2023

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Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate.
Charlotte R Pfeifer, Michael P Tobin, Sangkyun Cho, Manasvita Vashisth, Lawrence J Dooling, Dennis E Discher

Nucleus· December 2022

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Human CD47-Derived Cyclic Peptides Enhance Engulfment of mAb-Targeted Melanoma by Primary Macrophages.
AbdelAziz R Jalil, Jason C Andrechak, Brandon H Hayes, David M Chenoweth, Dennis E Discher

Bioconjug Chem· November 2022

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Suppressing or Enhancing Macrophage Engulfment through the Use of CD47 and Related Peptides.
AbdelAziz R Jalil, Michael P Tobin, Dennis E Discher

Bioconjug Chem· November 2022

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Challenges and opportunities for the next generation of cardiovascular tissue engineering.
Sangkyun Cho, Dennis E Discher, Kam W Leong, Gordana Vunjak-Novakovic, Joseph C Wu

Nat Methods· September 2022

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Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues.
Lawrence J Dooling, Karanvir Saini, Alişya A Anlaş, Dennis E Discher

Matrix Biol· August 2022

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Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins.
Mai Wang, Irena Ivanovska, Manasvita Vashisth, Dennis E Discher

APL Bioeng· June 2022

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CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies.
Jason C Andrechak, Lawrence J Dooling, Michael P Tobin, William Zhang, Brandon H Hayes, Dennis E Discher

Cancers (Basel)· April 2022

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Scaling concepts in 'omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis.
Manasvita Vashisth, Sangkyun Cho, Jerome Irianto, Yuntao Xia, Mai Wang, Dennis E Discher

Proc Natl Acad Sci U S A· November 2021

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Piezo1 and Piezo2 foster mechanical gating of K channels.
Edyta Glogowska, Malika Arhatte, Franck C Chatelain, Florian Lesage, Aimin Xu, Dennis E Discher

Cell Rep· November 2021

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Multivalent, Soluble Nano-Self Peptides Increase Phagocytosis of Antibody-Opsonized Targets while Suppressing "Self" Signaling.
AbdelAziz R Jalil, Brandon H Hayes, Jason C Andrechak, Yuntao Xia, David M Chenoweth, Dennis E Discher

ACS Nano· November 2020

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Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRPα structure-function.
AbdelAziz R Jalil, Jason C Andrechak, Dennis E Discher

Antib Ther· April 2020

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Macrophages show higher levels of engulfment after disruption of interactions between CD47 and the checkpoint receptor SIRPα.
Brandon H Hayes, Richard K Tsai, Lawrence J Dooling, Siddhant Kadu, Justine Y Lee, Dennis E Discher

J Cell Sci· March 2020

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